Patents by Inventor Shigeru Kawano

Shigeru Kawano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110237531
    Abstract: The present invention provides a low-cost, efficient method for producing a glycolipid biosurfactant, in particular, lactonic sophorose lipids. This method is characterized by culturing a microorganism capable of producing the biosurfactant under limited oxygen supply. The present invention enables preferential production of lactonic sophorose lipids and facilitates recovery of the lactonic sophorose lipids in a solid form. Further, the present invention enables production of high purity acidic sophorose lipids by hydrolyzing high purity lactonic sophorose lipids produced by the above method. The present invention also provides lactonic sophorose lipids that possess strong antibacterial and antifungal activities, and an antibacterial and/or antifungal agent containing the sophorose lipids.
    Type: Application
    Filed: October 23, 2009
    Publication date: September 29, 2011
    Applicant: KANEKA CORPORATION
    Inventors: Satohiro Yanagisawa, Shigeru Kawano, Yoshihiko Yasohara
  • Publication number: 20100035317
    Abstract: An object of the present invention is to provide a novel alcohol dehydrogenase, a gene for the alcohol dehydrogenase, a vector including the gene, a transformant transformed with the vector, and a method for producing an optically active alcohol by utilizing them. A feature of the present invention directs to a novel polypeptide isolated from Candida maltosa, a DNA coding for the polypeptide, and a transformant producing the polypeptide. Another feature of the present invention directs to a method for producing an optically-active alcohol by reducing a carbonyl compound with the polypeptide or the transformant.
    Type: Application
    Filed: November 27, 2007
    Publication date: February 11, 2010
    Applicant: Kaneka Corporation
    Inventors: Shigeru Kawano, Takeru Ishige, Keita Iguchi, Tozo Nishiyama, Yoshihiko Yasohara
  • Publication number: 20090148899
    Abstract: The present invention relates to a method for producing an optically-active amine compound. The method is characterized by using a transaminase (A), an ?-keto acid reductase (B), and an enzyme (C), each having specific properties, in an identical reaction system to convert a ketone compound into a corresponding optically-active amine compound in which a carbon atom with an amino group bonded thereto serves as an asymmetric point. The present invention also relates to a recombinant vector for use in the method. The present invention makes it possible to efficiently produce an optically-active amine compound.
    Type: Application
    Filed: May 28, 2007
    Publication date: June 11, 2009
    Inventors: Shigeru Kawano, Noriyuki Ito, Yoshihiko Yasohara
  • Publication number: 20090104671
    Abstract: The present invention relates to a method for producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters wherein a 2-(N-substituted aminomethyl)-3-oxobutyric acid ester is treated with an enzyme source capable of stereoselectively reducing said ester to the corresponding optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester having the (2S,3R) configuration. The present invention provides an efficient method for industrially producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters, in particular such compounds having the (2S,3R) configuration, which are useful as intermediates for the production of medicinal compounds, among others.
    Type: Application
    Filed: July 19, 2006
    Publication date: April 23, 2009
    Applicant: Kaneka Corporation
    Inventors: Yoshihiko Yasohara, Miho Yano, Shigeru Kawano, Noriyuki Kizaki
  • Publication number: 20090029429
    Abstract: The present invention relates to a process for producing an optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl)propionic acid derivative which comprises stereoselectively reducing an 2-oxo-3-(4-substituent-oxyphenyl)propionic acid by an enzyme and subjecting the thus-obtained optically active 2-hydroxy-3-(4-substituent-oxyphenyl)propionic acid to esterification of the carboxyl group according to need, then to alkylation of the hydroxyl group and, if necessary, to deprotection of an ether type protective group. The present invention may make it possible to produce an optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl)propionic acid derivative, which is useful as intermediates for the synthesis of medicinal compounds, efficiently, in a simple and easy manner, and commercially advantageously.
    Type: Application
    Filed: August 4, 2005
    Publication date: January 29, 2009
    Applicant: KANEKA CORPORATION
    Inventors: Tatsuya Honda, Hirofumi Maeda, Nobuo Nagashima, Shigeru Kawano, Yoshihiko Yasohara
  • Publication number: 20080050260
    Abstract: A scroll compressor is disclosed. A plurality of grooves (85) communicating with each other are formed on a sliding surface of a thrust bearing (53) subjected to the axial force received by a movable scroll (32). The areas surrounded by the plurality of the grooves (85) make up a plurality of insular pressure receiving portions (83) independent of each other. The pressure receiving portions (83) represent at least one half of the area of the sliding surface.
    Type: Application
    Filed: August 21, 2007
    Publication date: February 28, 2008
    Applicants: DENSO CORPORATION, NIPPON SOKEN INC.
    Inventors: Shigeki Iwanami, Sanemasa Kawabata, Tadashi Hotta, Takashi Inoue, Shigeru Kawano, Masato Komura, Yoshitaka Akiyama
  • Patent number: 7329518
    Abstract: The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing an enzyme or enzyme source to act on polycyclic acetylpyridine derivatives. The present invention also relates to a novel enzyme which can be used in the production method mentioned above, a DNA coding for said enzyme, a recombinant vector having said DNA, and a transformant having said recombinant vector. The invention further relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing the above novel enzyme or the above transformant to act on optically inactive polycyclic pyridineethanol derivatives.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: February 12, 2008
    Assignee: Kaneka Corporation
    Inventors: Shigeru Kawano, Miho Horikawa, Yoshihiko Yasohara, Junzo Hasegawa
  • Publication number: 20070037263
    Abstract: An object of the present invention is to provide a simple and easy process for producing optically active alcohols, specifically, a (R)-3-hydroxypentanenitrile, optically active 3-hydroxybutanoic esters, and optically active 1-phenylethanol derivatives, and to provide a novel enzyme useful for producing the above optically active alcohols, particularly a (R)-3-hydroxypentanenitrile. The present invention provides a novel acetoacetyl-CoA reductase capable of asymmetrically reducing a 3-ketopentanenitrile to produce a (R)-3-hydroxypentanenitrile having an optical purity of 99% e.e. or more; and a process for allowing the novel enzyme or a known acetoacetyl-CoA reductase to act on each of the 3-ketopentanenitrile, an acetoacetic ester, and a 1-phenylethanone derivative to produce a corresponding optically active alcohol.
    Type: Application
    Filed: November 10, 2004
    Publication date: February 15, 2007
    Inventors: Shigeru Kawano, Yoshihiko Yasohara
  • Patent number: 7148055
    Abstract: The present invention provides a method for preparing optically active 3-hydroxypentanenitrile with high yield. Optically active 3-hydroxypentanenitrile is prepared by stereoselectively reducing 3-ketopentanenitrile by action of an enzyme, which asymmetrically reduces 3-ketopentanenitrile to optically active 3-hydroxypentanenitrile. Also, alkali metal salt of 3-ketopentanenitrile, which is a stable compound without problems regarding storage, can be efficiently obtained.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: December 12, 2006
    Assignee: Kaneka Corporation
    Inventors: Shigeru Kawano, Yoshihiko Yasohara
  • Patent number: 7083396
    Abstract: In a fluid apparatus used as a compressor, a swing support member is constructed of a hook-type adjustable joint, and supports a swing member in capable of swinging while restricting the swing member from rotating about a center axis of a shaft of the compressor. A variable mechanism portion is constructed of a rotary member rotatable around the shaft, the swing member and the like. A slant center around which the swing member swings is made to substantially correspond to a center of gravity of the variable mechanism portion. Therefore, a slant moment, for changing a slant angle of the swing member, is not structurally generated. Accordingly, even when the compressor operates, large vibration and large noise can be prevented, thereby improving durability of the compressor.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: August 1, 2006
    Assignees: Denso Corporation, Nippon Soken, Inc.
    Inventors: Shigeru Kawano, Hirokazu Kamiya, Masafumi Inoue, Shigeru Kamiya, Mikio Matsuda, Takashi Inoue
  • Publication number: 20060000862
    Abstract: A spool for fishing lines according to this invention includes: an annular cover member (2) rotatably and removably fitted on peripheral edge portions of flanges (4); a support portion (9) protuberating on an upper surface of the cover member and having front and rear portions and opposite side edge portions; a cutter portion (10) dented from one of the side edge portions of the support portion, with the front and rear portions and the other side edge portion of the support portion (9) being kept as they are; a cutter (11) embedded within the support portion (9) in such a manner that only a cutting edge (11a) thereof protrudes into the cutter portion (10); and a fishing line retaining portion (13) having a clearance defined between the support portion (9) and a surface of the cover member (2) and extending from behind the support portion (9) to the cutting edge (11a).
    Type: Application
    Filed: April 7, 2005
    Publication date: January 5, 2006
    Applicant: Kawano Plastics Company
    Inventor: Shigeru Kawano
  • Publication number: 20060001002
    Abstract: A refrigerating cycle comprising a compressor 1 which compresses and discharges a refrigerant containing a refrigerating machine oil in a refrigerant circulating passage for lubricating the compressor 1, wherein fine particles 17 having a nearly circular shape in cross section are put into the refrigerant circulating passage. The fine particles 17 present between the sliding surfaces of the compressor prevent direct contact between the sliding surfaces. Besides, the fine particles 17 having a nearly circular shape in cross section roll when the opposing side surfaces move relative to each other creating rolling friction. Therefore, the coefficient of friction decreases on the sliding portions of the compressor 1.
    Type: Application
    Filed: June 30, 2005
    Publication date: January 5, 2006
    Inventors: Shigeki Iwanami, Shigeru Kawano, Teruhiko Kameoka, Shozo Ikejima, Takashi Honda
  • Publication number: 20040265991
    Abstract: The present invention provides a process for easily preparing a (S)-&agr;-halomethylpyridine-methanol derivative, which is useful as an intermediate of pharmaceutical products, from inexpensive raw materials. The (S)-&agr;-halomethylpyridine-methanol derivative is prepared by (S)-selectively reducing a 2-haloacetylpyridine derivative using an enzyme source having ability to (S)-selectively reduce a carbonyl group of the 2-haloacetylpyridine derivative, which can be obtained inexpensively. Also, a hydrohalic acid salt of (S)-&agr;-halomethyl-3-pyridine-methanol derivative is isolated and purified as crystal from a (S)-&agr;-halomethyl-3-pyridine-methanol derivative containing impurities using hydrohalic acid and an organic solvent.
    Type: Application
    Filed: April 16, 2004
    Publication date: December 30, 2004
    Inventors: Naoaki Taoka, Noriyuki Kizaki, Shigeru Kawano, Miho Horikawa, Yoshihiko Yasohara
  • Publication number: 20040235124
    Abstract: The present invention provides a method for preparing optically active 3-hydroxypentanenitrile with high yield. Optically active 3-hydroxypentanenitrile is prepared by stereoselectively reducing 3-ketopentanenitrile by action of an enzyme, which asymmetrically reduces 3-ketopentanenitrile to optically active 3-hydroxypentanenitrile. Also, alkali metal salt of 3-ketopentanenitrile, which is a stable compound without problems regarding storage, can be efficiently obtained.
    Type: Application
    Filed: March 26, 2004
    Publication date: November 25, 2004
    Inventors: Shigeru Kawano, Yoshihiko Yasohara
  • Patent number: 6737264
    Abstract: The present invention has for its object to provide a practical method for the purification and isolation on a commercial scale of said compound (1) or compound (2) in good yield and with high quality. The present invention provides a purification/isolation method of a (2S,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (1) or a (2R,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (2) which comprises, for the purpose of removing contaminant impurity from a mixture containing at least one of said compounds (1) and (2), causing the objective compound (1) or compound (2) to be crystallized in the presence of a solvent comprised of a hydrocarbon solvent and then collecting the obtained crystals.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: May 18, 2004
    Assignee: Kaneka Corporation
    Inventors: Katsuji Maehara, Shigeru Kawano, Makoto Yamaguchi, Yasuyoshi Ueda
  • Publication number: 20040043460
    Abstract: The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing an enzyme or enzyme source to act on polycyclic acetylpyridine derivatives.
    Type: Application
    Filed: September 25, 2003
    Publication date: March 4, 2004
    Applicant: Kaneka Corporation
    Inventors: Shigeru Kawano, Miho Horikawa, Yoshihiko Yasohara, Junzo Hasegawa
  • Publication number: 20030223887
    Abstract: In a fluid apparatus used as a compressor, a swing support member is constructed of a hook-type adjustable joint, and supports a swing member in capable of swinging while restricting the swing member from rotating about a center axis of a shaft of the compressor. A variable mechanism portion is constructed of a rotary member rotatable around the shaft, the swing member and the like. A slant center around which the swing member swings is made to substantially correspond to a center of gravity of the variable mechanism portion. Therefore, a slant moment, for changing a slant angle of the swing member, is not structurally generated. Accordingly, even when the compressor operates, large vibration and large noise can be prevented, thereby improving durability of the compressor.
    Type: Application
    Filed: May 16, 2003
    Publication date: December 4, 2003
    Inventors: Shigeru Kawano, Hirokazu Kamiya, Masafumi Inoue, Shigeru Kamiya, Mikio Matsuda, Takashi Inoue
  • Patent number: 6410773
    Abstract: Novel and useful optical active 2-aralkyl-3-sulfonyloxy-1-propanol and 2-aralkyl-3-sulfonyloxypropionic acid are provided by using an optical active 2-aralkyl-3-acyloxy-1-propanol as a starting material. Furthermore, an optical active 2-aralkyl-3-thiopropionic acid, which is an important intermediate of enkephalinase inhibitor, is provided. According to the present invention, industrially useful optical active sulfonic acid ester derivatives can be provided.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: June 25, 2002
    Assignee: Kaneka Corporation
    Inventors: Yoshihiko Yasohara, Kenji Miyamoto, Shigeru Kawano, Junzo Hasegawa
  • Patent number: 6121477
    Abstract: Optically active 2-aralkyl-3-sulfonyloxy-1-propanol and 2-aralkyl-3-sulfonyloxypropionic acid are provided by using an optically active 2-aralkyl-3-acyloxy-1-propanol as a starting material. Furthermore, an optically active 2-aralkyl-3-thiopropionic acid, which is an important intermediate for synthesis of enkephalinase inhibitors, is provided. According to the present invention, industrially useful optically active sulfonic acid ester derivatives can be provided.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: September 19, 2000
    Assignee: Kaneka Corporation
    Inventors: Yoshihiko Yasohara, Kenji Miyamoto, Shigeru Kawano, Junzo Hasegawa
  • Patent number: 6046354
    Abstract: A novel glycerol derivative, a process for preparing the same, and a process for preparing a triazole derivative. An optically active 2-arylglycerol derivative which is novel and useful as a synthetic intermediate of medicament is provided, and furthermore, (R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)-propane-1,2-diol, which is useful as an antifungal agent, is prepared.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: April 4, 2000
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yoshihiko Yasohara, Kenji Miyamoto, Noriyuki Kizaki, Shigeru Kawano, Junzo Hasegawa