Patents by Inventor Shigeyuki Imamura
Shigeyuki Imamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115586Abstract: An object of the present invention is to provide a therapeutic agent for pulmonary fibrosis which has high therapeutic effect. The invention provides a therapeutic agent for pulmonary fibrosis which comprises, as an active ingredient, a compound represented by the following formula (I): wherein R represents a linear or branched alkyl group having 1 to 30 carbon atoms, a linear or branched alkenyl group having 2 to 30 carbon atoms, or a linear or branched alkynyl group having 2 to 30 carbon atoms, which may contain a cycloalkane or aromatic ring; X and Y each independently represent an oxygen atom or a methylene group, provide that X and Y do not simultaneously represent a methylene group; and M represents a hydrogen atom or an alkali metal atom.Type: ApplicationFiled: November 25, 2021Publication date: April 11, 2024Applicant: SANSHO CO. LTD.Inventors: Kumiko SUZUKI, Katsutoshi KOBAYASHI, Shigeyuki IMAMURA, Toshiro MOROHOSHI
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Publication number: 20210071211Abstract: It is an object of the present invention to provide a method for easily producing sodium cyclic phosphatidic acid that can be used as food and drink. According to the present invention, provided is a method for producing sodium cyclic phosphatidic acid, comprising a step of allowing a lyso-type phospholipid to react with phospholipase D in the presence of sodium salts in an aqueous medium, and a step of recovering a precipitate or an upper layer liquid that is generated as a result of addition of ethyl alcohol to the obtained reaction solution.Type: ApplicationFiled: December 12, 2018Publication date: March 11, 2021Applicant: SANSHO Co. Ltd.Inventors: Shigeyuki IMAMURA, Yoshihiko NOGATA, Tatsuro FUJIWARA, Toshiro MOROHOSHI
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Patent number: 9290781Abstract: The present invention provides a method for producing a composition containing 2-acyl-lysophosphatidylserine, including (a) a step of obtaining a composition containing phosphatidylserine by allowing phospholipase D to act on a raw material containing phosphatidylcholine in the presence of serine and (b) a step of obtaining a composition containing 2-acyl-lysophosphatidylserine by allowing phospholipase A1 to act on the composition containing phosphatidylserine in the presence of one or more additives selected from the group consisting of the following (I), (II), and (III), in which (I) one or more salts selected from the group consisting of sulfate salts, phosphate salts, nitrate salts, citrate salts, and tartarate salts of monovalent cations, (II) a gum, and (III) an emulsifier.Type: GrantFiled: September 26, 2011Date of Patent: March 22, 2016Assignees: National University Corporation Tokyo University of Marine Science and Technology, Meiji Co., Ltd.Inventors: Kazunaga Yazawa, Tomoyuki Susa, Shoji Gotoh, Yasuhito Tashiro, Junichi Kawashima, Shigeyuki Imamura
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Publication number: 20130281404Abstract: The present invention provides a method for producing a composition containing 2-acyl-lysophosphatidylserine, including (a) a step of obtaining a composition containing phosphatidylserine by allowing phospholipase D to act on a raw material containing phosphatidylcholine in the presence of serine and (b) a step of obtaining a composition containing 2-acyl-lysophosphatidylserine by allowing phospholipase A1 to act on the composition containing phosphatidylserine in the presence of one or more additives selected from the group consisting of the following (I), (II), and (III), in which (I) one or more salts selected from the group consisting of sulfate salts, phosphate salts, nitrate salts, citrate salts, and tartarate salts of monovalent cations, (II) a gum, and (III) an emulsifier.Type: ApplicationFiled: September 26, 2011Publication date: October 24, 2013Applicant: MEIJI CO., LTD.Inventors: Kazunaga Yazawa, Tomoyuki Susa, Shoji Gotoh, Yasuhito Tashiro, Junichi Kawashima, Shigeyuki Imamura
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Publication number: 20120129202Abstract: Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are provided. Thus, the contents of a glycated protein and glycated albumin can be more accurately determined.Type: ApplicationFiled: December 9, 2011Publication date: May 24, 2012Inventors: Takuji Kouzuma, Issei Yoshioka, Motoo Arai, Junichi Sumitani, Shigeyuki Imamura
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Patent number: 8105766Abstract: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.Type: GrantFiled: February 27, 2009Date of Patent: January 31, 2012Assignees: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.Inventors: Shinichi Sakasegawa, Yoshiaki Ikura, Atsuhisa Nishimura, Toshihiko Kumazawa, Shigeyuki Imamura
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Patent number: 8105800Abstract: Composition for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) siabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are provided. Thus, the contents of a glycated protein and glycated albumin can be more accurately determined.Type: GrantFiled: July 31, 2007Date of Patent: January 31, 2012Assignee: Asahi Kasei Pharma CorporationInventors: Takuji Kouzuma, Issei Yoshioka, Motoo Arai, Junichi Sumitani, Shigeyuki Imamura
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Publication number: 20110312009Abstract: Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are provided. Thus, the contents of a glycated protein and glycated albumin can be more accurately determined.Type: ApplicationFiled: July 31, 2007Publication date: December 22, 2011Inventors: Takuji Kouzuma, Issei Yoshioka, Motoo Arai, Junichi Sumitani, Shigeyuki Imamura
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Patent number: 8080423Abstract: Stabilizers for colorants used for detection of enzymatic reactions, having a cyclodextrin and a catalase; reagents including stabilizers; and methods of use of such stabilizers and reagents.Type: GrantFiled: August 4, 2005Date of Patent: December 20, 2011Assignee: Asahi Kasei Pharma CorporationInventors: Takuji Kouzuma, Yoko Nagai, Shigeyuki Imamura
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Patent number: 7883862Abstract: Diglyceride solutions for lipase activity determination, comprising at least one diglyceride, a low concentration buffer, and a nonionic surfactant.Type: GrantFiled: November 18, 2005Date of Patent: February 8, 2011Assignee: Asahi Kasei Pharma CorporationInventor: Shigeyuki Imamura
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Publication number: 20090246783Abstract: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.Type: ApplicationFiled: February 27, 2009Publication date: October 1, 2009Applicants: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.Inventors: Shinichi SAKASEGAWA, Yoshiaki Ikura, Atsuhisa Nishimura, Toshihiko Kumazawa, Shigeyuki Imamura
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Publication number: 20080038765Abstract: [PROBLEMS] To provide lipase activity determination reagents which function by an enzymatic method. The reagents are easy to use in an ordinary clinical examination, have excellent handleability, and are excellent in accuracy and reproducibility. [MEANS FOR SOLVING PROBLEMS] Lipase activity is determined with any of reagents which comprise a low-concentration buffer and a diglyceride dissolved therein. The diglyceride is used as a substrate for lipase, whereby the liquid reagents can have long-term storage stability. One of the reagents converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, pyruvate kinase, lactate dehydrogenase, reduced NAD, ATP, and phosphoenol pyruvate.Type: ApplicationFiled: November 18, 2005Publication date: February 14, 2008Applicant: ASAHI KASEI PHARMA CORPORATIONInventor: Shigeyuki Imamura
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Publication number: 20070224685Abstract: Provided are: a protease reaction promoter which is superior in usefulness to the known protease reaction promoters; a stabilizer for a colorant used for detection of an enzymatic reaction, and a method of stabilizing the colorant; and a reagent for and a method of measuring a glycated protein and a ratio of a glycated protein using the same.Type: ApplicationFiled: August 4, 2005Publication date: September 27, 2007Applicant: ASAHI KASEI PHARMA CORPORATIONInventors: Takuji Kouzuma, Yoko Nagai, Shigeyuki Imamura
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Patent number: 7250269Abstract: Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) siabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are provided. Thus, the contents of a glycated protein and glycated albumin can be more accurately determined.Type: GrantFiled: January 30, 2002Date of Patent: July 31, 2007Assignee: Asahi Kasei Pharma CorporationInventors: Takuji Kouzuma, Issei Yoshioka, Motoo Arai, Junichi Sumitani, Shigeyuki Imamura
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Publication number: 20050101771Abstract: Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) siabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are provided. Thus, the contents of a glycated protein and glycated albumin can be more accurately determined.Type: ApplicationFiled: January 30, 2002Publication date: May 12, 2005Inventors: Takuji Kouzuma, Issei Yoshioka, Motoo Arai, Junichi Sumitani, Shigeyuki Imamura
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Patent number: 5508185Abstract: An enzyme immobilizing carrier is produced by dissolving low-molecular weight chitosan in an aqueous acid solution and dropping the solution into a basic solution to produce regenerated porous chitosan in particles, reacting the regenerated porous chitosan in particles with the glycidyl ether of an aliphatic polyalcohol, and reacting further the resulting chitosan with the acid halide or acid anhydride of a higher fatty acid in a polar organic solvent. An enzyme and a polyfunctional cross-linking agent are reacted with the carrier to covalently immobilize the enzyme on the carrier. In a preferred embodiment, the enzyme is lipase and the carrier is produced by introducing the glycidyl ether of an aliphatic polyalcohol at 0.01 to 0.4 mole to 1 mole of the pyranose ring residue of the chitosan and by introducing a higher fatty acid having a total carbon number of 6 to 20 at 0.05 to 1 mole to 1 mole of the pyranose ring residue of the chitosan.Type: GrantFiled: August 11, 1994Date of Patent: April 16, 1996Assignee: Fuji Spinning Co., Ltd.Inventors: Yoshihide Kawamura, Hiroaki Tanibe, Shigeyuki Imamura, Junko Harada
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Patent number: 5356790Abstract: Myo-inositol in a specimen is assayed by reacting a specimen containing myo-inositol with:a) myo-inositol dehydrogenase using a thio-NADP group or thio-NAD group and an NADP group or NAD group as coenzymes, and which catalyzes a reversible reaction forming myo-inosose from myo-inositol,b ) A.sub.1 andc) B.sub.1to effect a cycling reaction ##STR1## wherein A.sub.1 is a thio-NADP group, thio-NAD group, NADP group or NAD group, A.sub.2 is a reduced form of A.sub.1, when A.sub.1 is a thio-NADP group or thio-NAD group, B.sub.1 is a reduced NADP group or reduced NAD group and when A.sub.1 is an NADP group or NAD group, B.sub.1 is a reduced thio-NADP group or reduced thio-NAD group, and wherein B.sub.2 is an oxidized form of B.sub.1. The change in the amount of A.sub.2 generated or B.sub.1 consumed by the cycling reaction is measured to perform the assay. A composition for performing the assay comprises the above myo-inositol dehydrogenase, as well as the above components A.sub.1 and B.sub.1.Type: GrantFiled: August 16, 1993Date of Patent: October 18, 1994Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Shigeru Ueda, Mamoru Takahashi, Hideo Misaki, Shigeyuki Imamura, Kazuo Matsuura
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Patent number: 5238816Abstract: A novel .omega.-carboxyalcohol oxidase catalyzes at least one of the following reactions:R--CH.sub.2 OH+O.sub.2 .fwdarw.R--CHO+H.sub.2 O.sub.2 a)R--CHO+O.sub.2 +H.sub.2 O.fwdarw.R--COOH+H.sub.2 O.sub.2 b)wherein R is alkyl, alkenyl, .omega.-carboxyalkyl or .omega.-carboxyalkenyl. The enzyme has substrate specificity on at least 12-hydroxydodecanoic acid, 1-dodecanol, 1-decanol, 1-octanol and 1-hexanol, and has no substrate specificity on methanol, ethanol or glycerol. The enzyme does not require the presence of NAD or NADP for its use. Also disclosed is a process for producing the enzyme, an assay method for substrates of the enzyme, and a process for producing carboxylic acid employing the enzyme.Type: GrantFiled: November 5, 1991Date of Patent: August 24, 1993Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Shigeyuki Imamura, Naoki Muto, Kenya Ishizawa
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Patent number: 5206148Abstract: A method for assaying aliphatic alcohol, aliphatic aldehyde or .omega.-carboxylic acid derivatives thereof, using a novel .omega.-carboxyalcohol oxidase which catalyzes at least one of the following reactions:a) R--CH.sub.2 OH+O.sub.2 .fwdarw.R--CHO+H.sub.2 O.sub.2b) R--CHO+O.sub.2 +H.sub.2 O.fwdarw.R--COOH+H.sub.2 O.sub.2wherein R is alkyl, alkenyl, .omega.-carboxyalkyl or .omega.-carboxyalkenyl. The enzyme has substrate specificity on at least 12-hydroxydodecanoic acid, 1-dodecanol, 1-decanol, 1-octanol and 1-hexanol, and has no substrate specificity on methanol, ethanol or glycerol. The enzyme does not require the presence of NAD or NADP for its use. Also disclosed is a process for producing the enzyme, an assay method for substrates of the enzyme, and a process for producing carboxylic acid employing the enzyme.Type: GrantFiled: November 5, 1991Date of Patent: April 27, 1993Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Shigeyuki Imamura, Naoki Muto, Kenya Ishizawa
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Patent number: 5171681Abstract: A novel .omega.-carboxyalcohol oxidase catalyzes at least one of the following reactions:a) R--CH.sub.2 OH+O.sub.2 .fwdarw.R--CHO+H.sub.2 O.sub.2b) R--CHO+O.sub.2 +H.sub.2 O.fwdarw.R--COOH+H.sub.2 O.sub.2wherein R is alkyl, alkenyl, .omega.-carboxyalkyl or .omega.- carboxyalkenyl. The enzyme has substrate specificity on at least 12-hydroxydodecanoic acid, 1-dodecanol, 1-decanol, 1-octanol and 1-hexanol, and has no substrate specificity on methanol, ethanol or glycerol. The enzyme does not require the presence of NAD or NADP for its use. Also disclosed is a process for producing the enzyme, an assay method for substrates of the enzyme, and a process for producing carboxylic acid employing the enzyme.Type: GrantFiled: August 21, 1990Date of Patent: December 15, 1992Assignee: Toyo Jozo Kabushiki KaishaInventors: Shigeyuki Imamura, Naoki Muto, Kenya Ishizawa