Patents by Inventor Shimon Gatt

Shimon Gatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic analogs of sphingolipids
    Patent number: 9340488
    Abstract: The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: May 17, 2016
    Assignees: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Arie Dagan, Shimon Slavin, Shimon Gatt, Jeremy Zahavy
  • NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS
    Publication number: 20150073003
    Abstract: The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 12, 2015
    Inventors: Arie DAGAN, Shimon SLAVIN, Shimon GATT, Jeremy ZAHAVY
  • Synthetic analogs of sphingolipids
    Patent number: 8962891
    Abstract: The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
    Type: Grant
    Filed: November 9, 2008
    Date of Patent: February 24, 2015
    Assignees: Hadasit Medical Research Services & Development Limited, Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Arie Dagan, Shimon Slavin, Shimon Gatt, Jeremy Zahavi
  • NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS
    Publication number: 20110034542
    Abstract: The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
    Type: Application
    Filed: November 9, 2008
    Publication date: February 10, 2011
    Inventors: Arie Dagan, Shimon Slavin, Shimon Gatt, Jeremy Zahavi
  • SYNTHETIC SPHINGOLIPID ANALOGS
    Publication number: 20100311841
    Abstract: Therapeutic compounds based on synthetic sphingolipid analogs are provided, particularly alkylthiophenyl substituted ceramide analogs, suitable for treating degenerative, infectious, and other diseases.
    Type: Application
    Filed: November 6, 2008
    Publication date: December 9, 2010
    Inventors: Arie Dagan, Shimon Gatt, Shimon Slavin
  • Detection of binding of charged species using PH- or potential-sensitive probes
    Patent number: 7056653
    Abstract: The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is determined by stably incorporating at the surface a probe which contains a pH- or potential-sensitive fluorophore.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: June 6, 2006
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Yechezkel Barenholz, Danielle Hirsch-Lerner, Rivka Cohen, Arie Dagan, Shimon Gatt
  • Sphingolipids
    Patent number: 6756504
    Abstract: The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them. The compounds of formula (I) are inhibitors of various lipid-related enzymes. They can be used in reducing accumulation of sphingolipids and thus in the treatment of lipid storage diseases. The compounds of formula (I) can also be used for the treatment of cancerous diseases and for killing of wild type and drug-resistant cancer cells.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: June 29, 2004
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Arieh Dagan, Shimon Gatt
  • Sphingolipids
    Publication number: 20030133904
    Abstract: The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: October 17, 2002
    Publication date: July 17, 2003
    Inventors: Arieh Dagan, Shimon Gatt
  • Detection of binding of charged species using pH- or potential-sensitive probes
    Publication number: 20020012923
    Abstract: The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is determined by stably incorporating at the surface a probe which contains a pH- or potential-sensitive fluorophore.
    Type: Application
    Filed: February 8, 2001
    Publication date: January 31, 2002
    Inventors: Yechezkel Barenholz, Danielle Hirsch-Lerner, Rivka Cohen, Arie Dagan, Shimon Gatt
  • Moist, absorbent material for cleaning articles and surfaces
    Patent number: 5593508
    Abstract: The invention provides a moist, absorbent material for cleaning articles and surfaces, wherein the material is moistened with an aqueous solution containing liposomes having vesicles of a diameter of up to about 100 nm.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: January 14, 1997
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shimon Gatt, Yechezkel Barenholz, Herve Bercovier, Zvi Eldar
  • Method for cleaning the surfaces of a motor vehicle
    Patent number: 5542987
    Abstract: The invention provides a method for cleaning the surfaces of a motor vehicle which is contaminated with wastes containing organic or lipophilic deposits, comprising applying liposomes thereto, which liposomes modify the physical properties of the wastes to increase the polarity and wettability thereof.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: August 6, 1996
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shimon Gatt, Yechezkel Barenholz, Herve Bercovier, Zvi Eldar
  • Composition for enhancing the biodegradation of biodegradable organic wastes
    Patent number: 5510112
    Abstract: The invention provides a composition for enhancing the biodegradation of biodegradable organic wastes comprising a combination of organic-waste consuming microorganisms and liposomes wherein the liposomes supply essential nutrients for bacterial growth while concomitantly increasing the polarity and wettability of the waste, thereby increasing their availability for enhanced bacterial interaction therewith and methods for the use thereof.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: April 23, 1996
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shimon Gatt, Yechezkel Barenholz, Herve Bercovier
  • Phorbine derivatives and their use in the diagnosis and therapy of cancer
    Patent number: 5492924
    Abstract: Phorbine derivatives having high potency and light absorptivity in the 650 to 780 nanometer range are useful in cancer diagnosis and therapy, especially photodynamic therapy.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: February 20, 1996
    Assignees: Fox Chase Cancer Center, The French National Institute of Health and Medical Research (Inserm), Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shimon Gatt, Arie Dagan, Rene Santus, Jean-Claude Maziere, J. Donald Chapman, Edward L. Engelhardt
  • Method for enhancing the biodegradation of biodegradable organic wastes
    Patent number: 5401413
    Abstract: The invention provides a composition for enhancing the biodegradation of biodegradable organic wastes comprising a combination of organic-waste consuming microorganisms and liposomes wherein the liposomes supply essential nutrients for bacterial growth while concomitantly increasing the polarity and wettability of the waste, thereby increasing their availability for enhanced bacterial interaction therewith and methods for the use thereof.
    Type: Grant
    Filed: February 11, 1991
    Date of Patent: March 28, 1995
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shimon Gatt, Yechezkel Barenholz, Herve Bercovier
  • Method for cleaning industrial and domestic articles and surfaces contaminated with organic or lipophilic wastes
    Patent number: 5376183
    Abstract: The present invention provides a method for cleaning industrial and domestic surfaces and articles, as herein defined, which are contaminated with organic or lipophilic wastes, comprising applying liposomes thereto, which liposomes modify the physical properties of said wastes to increase the polarity and wettability thereof.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: December 27, 1994
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shimon Gatt, Yechezkel Barenholz, Herve Bercovier
  • Method for treating oil spills on water
    Patent number: 5244574
    Abstract: The invention provides a method for treating oil spills on water comprising applying liposomes to a body of water to form a monomolecular layer of phospholipid molecules on the water surface which phosopholipid molecules break up a continuous layer of oil into oil droplets each of which is surrounded by a monomolecular layer of phospholipids.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: September 14, 1993
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shimon Gatt, Yechezkel Barenholz
  • Enhanced oil recovery
    Patent number: 4811791
    Abstract: A method of recovering a petroleum from an underground source thereof comprising injecting into said underground source a petroleum displacement agent comprising a fluid and a modified liposome, said liposome being present in an amount sufficient to lower the interfacial tension between said fluid and said petroleum to below about 10 millidynes and the displacement agent.
    Type: Grant
    Filed: August 4, 1987
    Date of Patent: March 14, 1989
    Inventors: Gideon N. Harnoy, Shimon Gatt, Yechezkel Barenholtz