Abstract: The present invention is a pharmaceutical or food composition comprising a pretreated extract and an isolate and an isolated and purified product of Cinnamomum cassia showing a pharmacological effect. It relates to an active ingredient showing physiological activity in the Cinnamomum cassia extract.

Abstract: Provided is a time-to-digital converter, comprising a phase frequency detector configured to receive a phase-locked loop input clock and a feedback clock, a ring oscillator configured to perform oscillation with multi-phase clocks of a first period, a counter array configured to count the number of oscillations in which the ring oscillator oscillates in a first period by the number of positive integers during the first pulse width, a multiplexer configured to divide the first period into a plurality of zones using edge information of the multi-phase clocks of the ring oscillator, and selects and outputs voltage information of a plurality of neighboring phase clocks included in a first zone from the plurality of zones, an analog-to-digital converter, a calibrator, and a first adder, wherein the calibrator comprises, an offset lookup table generation circuit, a gain-corrected analog-to-digital conversion output generator, and a second adder.

Abstract: The present invention relates to a pharmaceutical composition comprising a DUSP1 inhibitor. The pharmaceutical composition comprising the DUSP1 inhibitor according to the present invention can solve the problems of inhibitors that target the active site because it inhibits DUSP1 by an allosteric inhibitory mechanism, and is effective for preventing or treating diseases involving DUSP1 enzymes, for example, a cancer such as a liver cancer, a breast cancer and a pancreatic cancer, a hepatitis C, and a depression. In particular, the DUSP1 inhibitor according to the present invention is very effective in treating a depression because it directly acts on neuronal growth.

Abstract: The present invention relates to a pharmaceutical composition comprising a DUSP1 inhibitor. The pharmaceutical composition comprising the DUSP1 inhibitor according to the present invention can solve the problems of inhibitors that target the active site because it inhibits DUSP1 by an allosteric inhibitory mechanism, and is effective for preventing or treating diseases involving DUSP1 enzymes, for example, a cancer such as a liver cancer, a breast cancer and a pancreatic cancer, a hepatitis C, and a depression. In particular, the DUSP1 inhibitor according to the present invention is very effective in treating a depression because it directly acts on neuronal growth.

Abstract: Provided are compositions and methods that involve recombinant Newcastle disease viruses (rNDVs), and recombinant vectors that encode them. The rNDVs comprise and/or encode a combination of at least two proteins that are hemagglutinin (HA), neuraminidase (NA) protein, matrix 1 protein (M1), or nonstructural 1 protein (NS1). The HA, NA, protein, M1, and nonstructural 1 protein (NS1) are from Avian Influenza virus (AIV). Method are provided and involve administering an immunologically effective amount rNDV to avian animals to stimulate a protective immune response the rNDV administration constitutes a first (prime) immunization, which can be followed by a second (boost) administration with an avirulent NVD that may include/encode an AIV HA. The avian animals can survive challenges from pathogenic and highly pathogenic NVD and AIV.

Abstract: The present invention is related to compositions for the induction of apoptosis containing phytosphingosine derivatives as effective components. The present invention is related to compositions for the induction of apoptosis containing Vit D3 or calcipotriol as an effective component in addition to phytosphingosine derivatives. The compositions of the present invention include pharmaceutical compositions or cosmetic compositions having an activity to induce apoptosis. The present invention offers a method of prevention or treatment of various skin diseases, various tumors, various cancers, etc. that may be prevented or cured by the induction of the activity of apoptosis in living bodies, which is comprised of the steps of administration of compositions for the induction of apoptosis containing phytosphingosine derivatives as effective components and irradiation of UVB to psoriatic lesions.