Abstract: A peptide nucleic acid derivative of Formula I is provided to tightly bind to a splice site within a pre-mRNA in a sequence specific manner. Given with excellent cell membrane permeability and strong affinity for RNA, the said peptide nucleic acid derivative induces exon skipping in cells treated with the peptide nucleic acid at sub-femtomolar concentration as “naked” oligonucleotide. The said compound shows therapeutic activity in subjects upon systemic administration even at 1 ?g/Kg or less, and therefore is useful to treat a disease or symptom at affordable treatment cost.

Abstract: A semiconductor device includes a substrate, a stack, and channel structures penetrating the stack. The stack includes gate electrodes and insulating layers alternately and repeatedly stacked on the substrate, and extending in a first direction. The channel structures in a first row are spaced apart from each other in the first direction. The stack includes a first sidewall that includes first recessed portions and first protruding portions. Each of first recessed portions is defined by an adjacent pair of the first recessed portions. Each of the first recessed portions has a shape recessed toward a first region of the stack between an adjacent pair of the channel structures of the first row. Each of the first recessed portions has a width that decreases in a direction toward the first region when measured along the first direction.

Abstract: An electronic device and a computer program product are provided herein.

Abstract: A power conversion device that converts power supplied via a first power feed bus and a second power feed bus, and includes: an inductance element connected to the first power feed bus; and a power module that converts power supplied between the first power feed bus and the second power feed bus by switching. The power conversion device further includes: a housing that houses the inductance element and the power module therein; and a first impedance element provided between the inductance element and the housing.

Abstract: The present disclosure relates to a protein having the activity of exporting O-acetylhomoserine and a novel modified protein thereof, a microorganism capable of producing O-acetylhomoserine with enhanced expression of the protein, and a method for producing O-acetylhomoserine using the microorganism.

Abstract: A flexible display apparatus is provided. The flexible display apparatus includes a display unit, a sensor configured to sense a bending of the flexible display apparatus, and a controller configured to display first contents on a first screen of the display unit, and to reconfigure and display the first contents on a second screen generated on an area of the display unit based on the bending.

Abstract: Provided is an electrode active material slurry including a clustered complex and a slurry, wherein the clustered complex includes an electrode active material, a solid electrolyte, a conductive material, and a first binder, and the slurry includes a solvent and a second binder. The electrode active material slurry may include the clustered complex including the first binder and the slurry including the second binder so as to decrease a surface area of the overall complex, such that adhesion property with the current collector may be sufficiently secured even by using a small amount of binder, and performance of the all-solid secondary battery may be further improved.

Abstract: The present invention relates to a process for preparing an intermediate for the preparation of eribulin mesylate with high yields, and an intermediate therefor.

Abstract: A method of preparing an immunological substance detection nanowire complex includes preparing a multilayer nanowire in which a first metal and a second metal are alternately stacked, attaching a polymer, having a carboxyl group and an amine group at both ends of the polymer, to the second metal, attaching a first antibody, treated with a thiol's group, to the first metal of the multilayer nanowire, and attaching a second antibody to the second metal through the carboxyl group of the polymer. The second antibody includes a phosphor.

Abstract: The present invention relates to a reinforcing material which is attached to a toecap embedded in a safety shoe so as to ensure the convenience and safety of a worker. The reinforcing material is combined with the toecap embedded in the safety shoe used generally so as to protect portions of an instep and toes of a worker, wherein a portion of the reinforcing material contacting with the instep is made of a flexible material such that a foot is comfortable during movement, and the reinforcing material having the portion made of the flexible material is combined with the safety shoe to effectively protect the foot, thereby improving the safety and efficiency of work performed by the worker.

Abstract: A pixel unit of a display device including: an OLED; a first transistor including a first electrode connected to a first node, a second electrode connected to a second node, and a third electrode connected to a third node; a capacitor including a first electrode receiving a power voltage and a second electrode connected to the first node; a second transistor including a first electrode receiving a scan signal, a second electrode receiving a data voltage and a third electrode connected to the second node; a third transistor including a first electrode receiving the scan signal, a second electrode connected to the first node and a third electrode connected to the third node, wherein at least one of the first and third transistors includes a fourth electrode, the fourth electrode receives a compensation voltage when an operation temperature is above a preset temperature and is floated when the operation temperature is equal to or more than the preset temperature.

Abstract: Provided are a glasses-free three-dimensional (3D) display device, a setting method of the same, and a using method of the same. The glasses-free 3D display device includes: a display device including a flat panel display; and a 3D viewing cover detachably disposed on the flat panel display, the 3D viewing cover configured to allow images displayed on the flat panel display to be viewed in three dimensions, wherein the display device includes a cover setting program executable by the display device to set setting parameters of the 3D viewing cover.

Abstract: Provided is a rolling roll including: a rolling roll body (112) installed to a rolling mill and used for rolling a material; and a surface treatment part formed on a surface of the rolling roll body (112) and coming into contact with the material, wherein the surface treatment part is formed to have fine concave and convex patterns forming ridges and valleys on a surface thereof, wherein the fine concave and convex patterns are formed such that the roughness skewness, indicating the difference between the height of the ridges and the depth of the valleys, has a negative (?) value.

Abstract: A laundry dryer according to one embodiment of the present invention comprises: a drying drum having an opening formed at the front side thereof; a front cabinet erected at the front side of the drying drum, and having an input hole formed at a portion corresponding to the opening; and a filter assembly mounted at the back side of the front cabinet corresponding to the lower side of the input hole, and through which humid air discharged from the drying drum passes, wherein the filter assembly can comprise: a case having an exhaust hole formed at the back side thereof; a blocking filter coupled to the upper side of the case; a lint filter unit penetrating the blocking filter so as to be slidably inserted or withdrawn in a vertical direction; a cleaning nozzle disposed at the front or rear of the lint filter unit; and a filter housing accommodated inside the case and disposed at the lower side of the lint filter unit.

Abstract: An embodiment of the disclosure discloses an electronic device including at least one camera module to capture an image based on a specified angle of view, a display to display the image, a processor electrically connected with the camera module and the display. The processor detects a plurality of objects in the image, and performs setting of image data associated with at least one object of the plurality of objects such that a region, which corresponds to the at least one object, in a screen region of the display has a specified light transmittance value. Moreover, various embodiment found through the disclosure are possible.

Abstract: The disclosure relates to an audio signal processing apparatus for processing an input audio signal, comprising a filter unit comprising a plurality of filters, each filter configured to filter the input audio signal to obtain a plurality of filtered audio signals, each filter designed according to an extended mode matching beamforming applied to a surface of a half revolution, the surface partially characterizing a loudspeaker enclosure shape, a plurality of scaling units, each scaling unit configured to scale the plurality of filtered audio signals using a plurality of gain coefficients to obtain a plurality of scaled filtered audio signals, and a plurality of adders, each adder configured to combine the plurality of scaled filtered audio signals, thereby providing an output audio signal for producing a sound field having a beam directivity pattern defined by the plurality of gain coefficients.

Abstract: A display device is disclosed. The display device includes a display including a backlight comprising a plurality of light sources and a display panel and configured to display a background image including a preset object, a sensor disposed at an outer part of the display and configured to sense an external lighting environment and a processor configured to determine a direction of a lighting based on the sensed lighting environment, to display a shadow object for the preset object at a position corresponding to the determined lighting direction, and to adjust a brightness of a light source corresponding to a position of the shadow object from among the plurality of light sources based on the sensed lighting environment.

Abstract: A method for preventing or treating hyperlipidemia includes administrating a composition consisting of a Salvia miltiorrhiza extract, a Crataegus pinnatifida extract, a Polygonum multiflorum extract, and a Ligusticum chuanxiong extract to a subject in need thereof. The composition may reduce an amounts of serum cholesterol and LDL-cholesterol and increase an amount of HDL-cholesterol, significantly reduce an amount of serum triglyceride compared with existing statin-based drugs, thereby exhibiting prophylactic and therapeutic effects of hyperlipidemia with various symptoms even without the co-administration of other drugs; and reduce an amounts of hepatic cholesterol and triglyceride, thereby exhibiting an effect of inhibiting fatty liver.

Abstract: A multilayer electronic component includes a body having a stacked structure in which a plurality of internal electrodes and dielectric layers are alternately stacked; and external electrodes disposed on an outer surface of the body and connected to the internal electrodes. The dielectric layer includes a plurality of grains and a plurality of graphene particles, and the plurality of graphene particles are disposed at boundaries of the plurality of grains.

Abstract: A cleaner includes a main body having an opening, a suction motor accommodated in the main body and configured to generate suction force, an opening cover separably coupled to the main body and configured to cover the opening, a motor housing configured to surround the suction motor, a flow guide disposed to surround at least a portion of the motor housing and spaced apart from the motor housing, and a filter mechanism disposed between the motor housing and the flow guide and including a filter member configured to filter dust contained in introduced air. The filter member is disposed to surround the motor housing, and the filter member includes a first filter unit and a second filter unit extends in a direction in which the first and second filter units cross each other.