Patents by Inventor Shinji Nara

Shinji Nara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7919517
    Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 5, 2011
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yoshihisa Ohta, Fumihiko Kanai, Shinji Nara, Yutaka Kanda, Hiroshi Umehara, Yukimasa Shiotsu, Tomoki Naoe, Hitoshi Kiyoi, Keiko Kawashima, Hiromi Ando, Motoki Miyama
  • Patent number: 7767693
    Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: August 3, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Shinji Nara, Hiroshi Nakagawa, Yutaka Kanda, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Jun-ichi Saito, Yukimasa Shiotsu, Shiro Akinaga
  • Patent number: 7605272
    Abstract: The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(?O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: October 20, 2009
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yutaka Kanda, Hiromi Ando, Keiko Kawashima, Takamasa Sugita, Masayo Suzuki, Hisashi Tagaya, Tomoyuki Nakazato, Yoshinori Yamashita, Takeshi Takahashi, Shinji Nara, Hiroaki Nakamura
  • Publication number: 20090247522
    Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
    Type: Application
    Filed: April 22, 2009
    Publication date: October 1, 2009
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Shinji Nara, Hiroshi Nakagawa, Yutaka Kanda, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Jun-ichi Saito, Yukimasa Shiotsu, Shiro Akinaga
  • Patent number: 7538241
    Abstract: (wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.
    Type: Grant
    Filed: December 24, 2004
    Date of Patent: May 26, 2009
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yushi Kitamura, Shinji Nara, Hiroshi Nakagawa, Rieko Nakatsu, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Yukimasa Shiotsu, Yutaka Kanda
  • Patent number: 7538224
    Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: May 26, 2009
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Shinji Nara, Hiroshi Nakagawa, Yutaka Kanda, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Jun-ichi Saito, Yukimasa Shiotsu, Shiro Akinaga
  • Publication number: 20090082348
    Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a
    Type: Application
    Filed: November 21, 2008
    Publication date: March 26, 2009
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Yoshihisa Ohta, Fumihiko Kanai, Shinji Nara, Yutaka Kanda, Hiroshi Umehara, Yukimasa Shiotsu, Tomoki Naoe, Hitoshi Kiyoi, Keiko Kawashima, Hiromi Ando, Motoki Miyama
  • Publication number: 20090054508
    Abstract: The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(?O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.
    Type: Application
    Filed: January 27, 2006
    Publication date: February 26, 2009
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yutaka Kanda, Hiromi Ando, Keiko Kawashima, Takamasa Sugita, Masayo Suzuki, Hisashi Tagaya, Tomoyuki Nakazato, Yoshinori Yamashita, Takeshi Takahashi, Shinji Nara, Hiroaki Nakamura
  • Publication number: 20090042883
    Abstract: The present invention provides a therapeutic agent for a tumor selected from a hematopoietic tumor and a solid tumor which comprises, as an active ingredient, a benzoyl compound represented by General Formula (I): (wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R3 and R5 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl or the like), a prodrug thereof or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 21, 2006
    Publication date: February 12, 2009
    Applicant: KYOWA HAKKOKOGYO CO.
    Inventors: Yutaka Kanda, Shiro Soga, Takayuki Nakashima, Shinji Nara, Hiroshi Nakagawa, Yukimasa Shiotsu
  • Patent number: 7470717
    Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: December 30, 2008
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yoshihisa Ohta, Fumihiko Kanai, Shinji Nara, Yutaka Kanda, Hiroshi Umehara, Yukimasa Shiotsu, Tomoki Naoe, Hitoshi Kiyoi, Keiko Kawashima, Hiromi Ando, Motoki Miyama
  • Publication number: 20070155813
    Abstract: wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.
    Type: Application
    Filed: December 24, 2004
    Publication date: July 5, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yushi Kitamura, Shinji Nara, Hiroshi Nakagawa, Rieko Nakatsu, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Yukimasa Shiotsu, Yutaka Kanda
  • Publication number: 20070117856
    Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents
    Type: Application
    Filed: July 30, 2004
    Publication date: May 24, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yoshihisa Ohta, Fumihiko Kanai, Shinji Nara, Yutaka Kanda, Hiroshi Umehara, Yukimasa Shiotsu, Tomoki Naoe, Hitoshi Kiyoi, Keiko Kawashima, Hiromi Ando, Motoki Miyama
  • Publication number: 20070032532
    Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
    Type: Application
    Filed: June 10, 2004
    Publication date: February 8, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Shinji Nara, Hiroshi Nakagawa, Yutaka Kanda, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Jun-ichi Saito, Yukimasa Shiotsu, Shiro Akinaga
  • Publication number: 20060281789
    Abstract: The present invention provides a protein kinase inhibitor (excluding c-Jun N-terminal kinase inhibitor) which comprises, as an active ingredient, an indazole derivative represented by Formula (I) (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 30, 2004
    Publication date: December 14, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Yukimasa Shiotsu, Hiroshi Umehara, Fumihiko Kanai, Shinji Nara, Yoshihisa Ohta, Yutaka Kanda, Shiro Akinaga, Tomoki Naoe, Hitoshi Kiyoi, Tomoyuki Nakazato, Satoshi Tashiro
  • Patent number: 6869971
    Abstract: UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, or is combined with R3 to represent a bond, etc., or is combined with R4 to represent —O(C?O)—, etc.; R3 represents hydrogen, etc., or is combined with R2 to represent a bond, etc.; R4 represents hydrogen, etc., or is combined with R2 to represent —(C?O)O—, etc.; R5 represents hydrogen or is combined with R6 to represent a bond; R6 represents hydrogen, etc., or is combined with R5 to represent a bond; R7 represents hydrogen or is combined with R8 to represent ?O; R8 represents hydroxy or is combined with R7 to represent ?O; ---- represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: March 22, 2005
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsutomu Akama, Akira Asai, Tsutomu Agatsuma, Shinji Nara, Yoshinori Yamashita, Tamio Mizukami, Shun-ichi Ikeda, Yutaka Saitoh, Yutaka Kanda
  • Patent number: 6861530
    Abstract: This invention relates to substituted piperidine derivatives having at least one six-membered ring substituent. The piperidine derivatives exhibit antitumor activity and are useful as pharmaceuticals such as an antitumor agent.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: March 1, 2005
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Shinji Nara, Rieko Nakatsu, Yutaka Kanda, Shiro Akinaga, Mitsunobu Hara, Jun Eishima, Timothy A. Grese, Douglas L. Gernert
  • Publication number: 20020137770
    Abstract: This invention relates to piperidine derivatives having antitumor activity and useful as pharmaceuticals such as an antitumor agent.
    Type: Application
    Filed: July 6, 2001
    Publication date: September 26, 2002
    Inventors: Shinji Nara, Rieko Nakatsu, Yutaka Kanda, Shiro Akinaga, Mitsunobu Hara, Jun Eishima, Timothy A. Grese, Douglas L. Gernert