Patents by Inventor Shinji Satomura

Shinji Satomura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9429572
    Abstract: An object of the present invention is to provide a method for forming a complex between an analyte or an analog thereof, and a substance formable the complex with said analyte or said analog thereof (the complex forming substance), in a short time and in high reaction efficiency, and a method for separating a complex formed, and a complex forming substance not involved in formation of said complex or an analog not involved in formation of said complex rapidly, simply and in high accuracy, along with a method for measuring an analyte in a sample in high sensitivity.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: August 30, 2016
    Assignee: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventors: Tomohisa Kawabata, Shinji Satomura, Henry Garrett Wada
  • Patent number: 7910380
    Abstract: The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: March 22, 2011
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tomohisa Kawabata, Shinji Satomura, Henry Garrett Wada
  • Publication number: 20110027902
    Abstract: The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity.
    Type: Application
    Filed: October 7, 2010
    Publication date: February 3, 2011
    Inventors: Tomohisa Kawabata, Shinji Satomura, Henry Garrett Wada
  • Patent number: 7842175
    Abstract: The invention relates to a method for separating a target for measurement utilizing electrophoresis, particularly capillary electrophoresis efficiently in high sensitivity and in a short period of time. It also relates to a method for measuring said target separated by said method for separation. The invention provides a method for separating a target for measurement and a method for measuring said target separated by said method for separation, characterized by using a substance to which is bound a nucleic acid chain labeled by a marker and which has an affinity for said target for measurement.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: November 30, 2010
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tomohisa Kawabata, Kenji Nakamura, Shinji Satomura
  • Patent number: 7833804
    Abstract: The present invention relates to a solution introducing structure for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel (1) of a micro fluidic device, said channel (1) comprising not less than three side channels (2) for drain and not less than two side channels (3) for introducing a sample or a reagent solution.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: November 16, 2010
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tomohisa Kawabata, Shinji Satomura, Henry Garrett Wada
  • Publication number: 20090321263
    Abstract: To enable reuse of expensive microchips in a clinical analysis apparatus, while constantly and efficiently obtaining accurate analysis results. A clinical apparatus employs microchips to analyze substances, which are contained in samples and are targets of measurement. The clinical analysis apparatus is equipped with: a stocking section; a dispensing mechanism, for dispensing reagents stocked in the stocking section and samples to the microchips; and a measuring section, for measuring the measurement target substance within the samples. The measuring section includes: a dispensing station, at which the microchips are provided; a detecting station, for detecting the measurement target substance; and a cleansing station, at which microchips are cleansed following detection of the measurement target substance. The dispensing station, the detecting station, and the cleansing station are provided at a predetermined pitch from upstream to downstream positions.
    Type: Application
    Filed: September 17, 2007
    Publication date: December 31, 2009
    Applicants: FUJIFILM CORPORATION, WAKO PURE CHEMICAL INDUSTRIES, LTD., CALIPER LIFE SCIENCES, INC.
    Inventors: Youichi Endo, Yoshihiro Seto, Shinji Satomura, Masayoshi Hayashi, Mitsuo Watanabe, Colin Kennedy, Michael Greenstein, Cheryl Cathey
  • Publication number: 20090280573
    Abstract: The present invention relates to a solution introducing structure for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel (1) of a micro fluidic device, said channel (1) comprising not less than three side channels (2) for drain and not less than two side channels (3) for introducing a sample or a reagent solution.
    Type: Application
    Filed: April 11, 2007
    Publication date: November 12, 2009
    Inventors: Tomohisa Kawabata, Shinji Satomura, Henry Garrett Wada
  • Publication number: 20090152114
    Abstract: An object of the present invention is to provide a method for forming a complex between an analyte or an analogue thereof, and a substance formable the complex with said analyte or said analogue thereof (the complex forming substance), in a short time and in high reaction efficiency, and a method for separating a complex formed, and a complex forming substance not involved in formation of said complex or an analogue not involved in formation of said complex rapidly, simply and in high accuracy, along with a method for measuring an analyte in a sample in high sensitivity.
    Type: Application
    Filed: August 24, 2006
    Publication date: June 18, 2009
    Inventors: Tomohisa Kawabata, Shinji Satomura, Henry Garrett Wada
  • Patent number: 6828417
    Abstract: A living body component in a sample derived from a living body can be rapidly and accurately measured by reacting the sample with a reagent comprising a combined product of an affinity substance and a polypeptide having at least three acid residues derived from a strong acid, separating the resulting complex by a method applying negative change such as using an anion-exchanger, and determining the amount of the analyte to be measured, on the basis of the amount of the complex or free combined product.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: December 7, 2004
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Nobuko Imajo, Yukari Yamagata, Hideo Katoh, Shinji Satomura, Kenji Nakamura
  • Publication number: 20040185512
    Abstract: The present invention relates to a method for detection of carcinoembryonic antigens (hereinafter abbreviated as CEAs) having a modified sugar chain structure which comprises using an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs, a method for detecting a cancer which comprises using an amount of CEAs having a modified sugar chain structure and a kit for detection of CEAs having a modified sugar chain structure which comprises an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 23, 2004
    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventors: Hideaki Hosokawa, Kenji Nakamura, Shinji Satomura
  • Publication number: 20040144649
    Abstract: The invention relates to a method for separating a target for measurement utilizing electrophoresis, particularly capillary electrophoresis efficiently in high sensitivity and in a short period of time. It also relates to a method for measuring said target separated by said method for separation. The invention provides a method for separating a target for measurement and a method for measuring said target separated by said method for separation, characterized by using a substance to which is bound a nucleic acid chain labeled by a marker and which has an affinity for said target for measurement.
    Type: Application
    Filed: October 2, 2003
    Publication date: July 29, 2004
    Inventors: Tomohisa Kawabata, Kenji Nakamura, Shinji Satomura
  • Publication number: 20040082006
    Abstract: An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating &agr;-fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the &agr;-fetoproteins which have a specific sugar chain structure, relative to the total &agr;-fetoproteins.
    Type: Application
    Filed: October 17, 2003
    Publication date: April 29, 2004
    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventors: Ritsu Yamamoto, Shinji Satomura
  • Patent number: 6677123
    Abstract: An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating &agr;-fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the &agr;-fetoproteins which have a specific sugar chain structure, relative to the total &agr;-fetoproteins.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: January 13, 2004
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Ritsu Yamamoto, Shinji Satomura
  • Publication number: 20020045189
    Abstract: A living body component in a sample derived from a living body can be rapidly and accurately measured by reacting the sample with a reagent comprising a combined product of an affinity substance and a polypeptide having at least three acid residues derived from a strong acid, separating the resulting complex by a method applying negative change such as using an anion-exchanger, and determining the amount of the analyte to be measured, on the basis of the amount of the complex or free combined product.
    Type: Application
    Filed: June 19, 2001
    Publication date: April 18, 2002
    Applicant: Wako Pure Chemical Industries, LTD.
    Inventors: Nobuko Imajo, Yukari Yamagata, Hideo Katoh, Shinji Satomura, Kenji Nakamura
  • Publication number: 20020009709
    Abstract: A method for measuring thyroglobulin(s), comprising using each one or more kinds of proteins capable of binding to a constant region of thyroglobulin(s) and proteins capable of specifically binding to a specific sugar chain structure of thyroglobulin(s) having the specific sugar chain structure, and the method of determining a malignancy of thyroid tumor, a reagent thereof using the obtained by the method for measuring thyroglobulin(s).
    Type: Application
    Filed: June 28, 1999
    Publication date: January 24, 2002
    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventors: RYOJI KATO, MASAYUKI MARUYAMA, KENJI NAKAMURA, KAYOKO SHIMIZU, SHINJI SATOMURA
  • Patent number: 6300079
    Abstract: A living body component in a sample derived from a living body can be rapidly and accurately measured by reacting the sample with a reagent comprising a combined product of an affinity substance and a polypeptide having at least three acid residues derived from a strong acid, separating the resulting complex by a method applying negative change such as using an anion-exchanger, and determining the amount of the analyte to be measured, on the basis of the amount of the complex or free combined product.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: October 9, 2001
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Nobuko Imajo, Yukari Yamagata, Hideo Katoh, Shinji Satomura, Kenji Nakamura
  • Patent number: 6156195
    Abstract: The object of the present invention is to provide a method for separating components in a liquid specimen and an apparatus used in said method, by which it is possible to avoid carryover even when the specimen injector is not washed using washing solution and also to avoid the increase of inner pressure in column of the separation device or ineffective separating operation even when many liquid specimens are separated by many times using the same separation device. In the present invention, the liquid specimen is introduced into the separation device from a direction opposite to eluting direction of the separation device which retains an adsorbent, and by separating and eluting the specimen from eluting outlet together with the eluant, trace quantity of insoluble substances and the specimen remained on the specimen introducing passage can be removed by elution procedure.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: December 5, 2000
    Assignees: Shimadzu Corporation, Wako Pure Chemical Industries, Ltd.
    Inventors: Kenji Nakamura, Shinji Satomura, Masayoshi Hayashi, Hideyoshi Arashima, Tetsushi Okuyama, Nobuhiro Hanafusa, Koji Tanimizu
  • Patent number: 6149818
    Abstract: The object of the present invention is to provide a method for separating components in a liquid specimen and an apparatus used in said method, by which it is possible to avoid carryover even when the specimen injector is not washed using washing solution and also to avoid the increase of inner pressure in column of the separation device or ineffective separating operation even when many liquid specimens are separated by many times using the same separation device. In the present invention, the liquid specimen is introduced into the separation device from a direction opposite to eluting direction of the separation device which retains an adsorbent, and by separating and eluting the specimen from eluting outlet together with the eluant, trace quantity of insoluble substances and the specimen remained on the specimen introducing passage can be removed by elution procedure.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: November 21, 2000
    Assignees: Shimadzu Corporation, Wako Pure Chemical Industries, Ltd.
    Inventors: Kenji Nakamura, Shinji Satomura, Masayoshi Hayashi, Hideyoshi Arashima, Tetsushi Okuyama, Nobuhiro Hanafusa, Koji Tanimizu
  • Patent number: 5780247
    Abstract: Two or more analytes having the same action, or having different actions in spite of their similar structures, or two or more analytes having the same action and the same detectable chemical characteristics, in samples derived from living bodies, etc., can be measured rapidly and easily by forming one or more complexes with one or more affinity substances, separating the complexes by using high pressure liquid chromatography, followed by measurement of the amount of an affinity substance or one of the analytes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 14, 1998
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Shinji Satomura, Kenji Nakamura, Shuji Matuura
  • Patent number: 5677194
    Abstract: Trace components in samples can be measured rapidly with high precision by applying interaction between an analyte to be measured and an affinity substance and using a membrane having specific separating capability.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: October 14, 1997
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Shinji Satomura, Hideo Katoh, Kenji Nakamura, Kazunari Hirayasu