Patents by Inventor Shinjiro Kasahara

Shinjiro Kasahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220119498
    Abstract: To provide an immunoglobulin purification method which achieves a high immunoglobulin recovery percentage without causing loss of the antibody nature of an immunoglobulin. The immunoglobulin purification method includes an adsorption step and a desorption step. The adsorption step involves adsorption of an immunoglobulin onto porous zirconia particles in a neutral buffer. The desorption step involves desorption of the immunoglobulin adsorbed on the porous zirconia particles from the porous zirconia particles by means of a neutral desorption liquid.
    Type: Application
    Filed: January 17, 2020
    Publication date: April 21, 2022
    Applicants: NGK Spark Plug Co., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Katsuya KATO, Fukue NAGATA, Shinjiro KASAHARA, Yuki HIROBE, Jun OTSUKA
  • Publication number: 20220089453
    Abstract: Porous zirconia particles exhibit high specificity to a protein to be immobilized thereto and are used in immobilization of the protein. The porous zirconia particles have a pore diameter D50, at which a ratio of a cumulative pore volume to a total pore volume is 50%, the pore diameter D50 being in a range of 3.20 nm or more and 6.50 nm or less; and a pore diameter D90, at which a ratio of a cumulative pore volume to a total pore volume is 90%, the pore diameter D90 being in a range of 10.50 nm or more and 100.00 nm or less. The total pore volume of the particles is greater than 0.10 cm3/g. D50, D90, and the total pore volume are determined based on a pore diameter distribution measured through a BET method.
    Type: Application
    Filed: January 17, 2020
    Publication date: March 24, 2022
    Applicants: NGK Spark Plug Co., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Katsuya KATO, Fukue NAGATA, Shinjiro KASAHARA, Jun OTSUKA, Yuki HIROBE
  • Publication number: 20210054153
    Abstract: The hydrogel includes a first network structure and a second network structure. The second network structure is entwined with the first network structure. The first network structure contains a polymer crosslinked with a first crosslinking agent. The second network structure contains a polymer crosslinked with a second crosslinking agent. 50 mol % or more of the first crosslinking agent does not contain a decomposable bond. 50 mol % or more of the second crosslinking agent does not contain a decomposable bond.
    Type: Application
    Filed: April 23, 2019
    Publication date: February 25, 2021
    Applicants: NGK SPARK PLUG CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKAIDO UNIVERSITY
    Inventors: Masaya IWATA, Shinjiro KASAHARA, Jian Ping GONG, Takayuki KUROKAWA, Takayuki NONOYAMA
  • Patent number: 10660990
    Abstract: A method of producing an article with a foamed surface which includes: a step 1 of forming small pores in a surface of a base made of a plastic to produce a base with small pores; a step 2 of immersing the base with small pores, obtained in step 1, in a solution including a foaming agent to prepare a foaming agent-including base; a step 3 of immersing the foaming agent-including base, obtained in step 2, in a foaming solution that makes the plastic swell and the foaming agent foam to prepare a foamed base; and a step 4 of immersing the foamed base, obtained in step 3, in a coagulating solution that coagulates the swollen plastic.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: May 26, 2020
    Assignee: NGK SPARK PLUG CO., LTD.
    Inventors: Shinjiro Kasahara, Takenori Sawamura
  • Patent number: 10238774
    Abstract: Provided is a biological implant which exhibits high binding ability to a biological tissue after having been embedded in a living organism, which secures an appropriate strength depending on a site to which the implant is applied, and in which a micropore structural portion is less likely to be removed from a macropore structural portion. The biological implant includes a macropore structural portion which defines macropores of the biological implant, and a micropore structural portion which has micropores therein, the micropores having a pore size smaller than that of the macropores, the biological implant being characterized in that the macropore structural portion has substantially no pores therein; the micropore structural portion is provided on the surface of the macropore structural portion; the macropore structural portion and the micropore structural portion are formed of the same engineering plastic material; and the macropore structural portion is formed of a single material.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: March 26, 2019
    Assignee: NGK SPARK PLUG CO., LTD.
    Inventors: Shinjiro Kasahara, Masaya Iwata, Takenori Sawamura
  • Publication number: 20180200410
    Abstract: A method of producing an article with a foamed surface which includes: a step 1 of forming small pores in a surface of a base made of a plastic to produce a base with small pores; a step 2 of immersing the base with small pores, obtained in step 1, in a solution including a foaming agent to prepare a foaming agent-including base; a step 3 of immersing the foaming agent-including base, obtained in step 2, in a foaming solution that makes the plastic swell and the foaming agent foam to prepare a foamed base; and a step 4 of immersing the foamed base, obtained in step 3, in a coagulating solution that coagulates the swollen plastic.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 19, 2018
    Applicant: NGK SPARK PLUG CO., LTD.
    Inventors: Shinjiro KASAHARA, Takenori SAWAMURA
  • Patent number: 9931438
    Abstract: The objection of this invention is to provide an article with a foamed surface having a porous structure in the surface of a plastic base, an implant and a method of producing them. The article has a body and a superficial layer formed in a surface of the body, the layer including small-diameter and large-diameter pores, wherein part of the small-diameter and large-diameter pores are open pores which are open at the surface of the layer; the open pores have small open pores with an average diameter of 5 ?m or less and large open pores with an average diameter from 10 to 200 ?m; and the large open pores have an inner wall with passages connected with the small-diameter large-diameter pores. The implant is the article itself or the article with a bioactive substance in the layer thereof. The method provides an example of producing the article and implant.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: April 3, 2018
    Assignee: NGK SPARK PLUG CO., LTD.
    Inventors: Shinjiro Kasahara, Takenori Sawamura
  • Publication number: 20160228615
    Abstract: Provided is a biological implant which exhibits high binding ability to a biological tissue after having been embedded in a living organism, which secures an appropriate strength depending on a site to which the implant is applied, and in which a micropore structural portion is less likely to be removed from a macropore structural portion. The biological implant includes a macropore structural portion which defines macropores of the biological implant, and a micropore structural portion which has micropores therein, the micropores having a pore size smaller than that of the macropores, the biological implant being characterized in that the macropore structural portion has substantially no pores therein; the micropore structural portion is provided on the surface of the macropore structural portion; the macropore structural portion and the micropore structural portion are formed of the same engineering plastic material; and the macropore structural portion is formed of a single material.
    Type: Application
    Filed: September 3, 2014
    Publication date: August 11, 2016
    Inventors: Shinjiro KASAHARA, Masaya IWATA, Takenori SAWAMURA
  • Publication number: 20110022181
    Abstract: The objection of this invention is to provide an article with a foamed surface having a porous structure in the surface of a plastic base, an implant and a method of producing them. The article has a body and a superficial layer formed in a surface of the body, the layer including small-diameter and large-diameter pores, wherein part of the small-diameter and large-diameter pores are open pores which are open at the surface of the layer; the open pores have small open pores with an average diameter of 5 ?m or less and large open pores with an average diameter from 10 to 200 ?m; and the large open pores have an inner wall with passages connected with the small-diameter large-diameter pores. The implant is the article itself or the article with a bioactive substance in the layer thereof. The method provides an example of producing the article and implant.
    Type: Application
    Filed: September 29, 2008
    Publication date: January 27, 2011
    Applicant: NGK SPARK PLUG CO., LTD.
    Inventors: Shinjiro Kasahara, Takenori Sawamura