Abstract: A calibration curve setting method used at the time of quantitatively analyzing specific components in a drug by a transmission Raman spectrum, the method comprising the steps of: obtaining respective transmission Raman spectra of a plurality of different wave number ranges including Raman hands corresponding to the specific components of a plurality of known drugs of which concentrations or amounts of the specific components are known and the concentrations or the amounts are different from each other; calculating candidate calibration curves which are candidates for calibration curves used for the quantitative analysis respectively from a plurality of transmission. Raman spectra in each of the wave number ranges; and using the most probable candidate calibration curve as a calibration curve for the quantitative analysis of the specific components, among the respective candidate calibration curves.

Abstract: A needle-shaped body protrudes from a cantilever made of Si. Furthermore, the rear face of the cantilever is coated with aluminum (first metal) having a Fermi level higher than that of Si. The cantilever is dipped into an aqueous silver nitride solution containing the ions of Ag serving as a second metal. The electrons of Si flow out to the aqueous silver nitride solution due to the existence of the aluminum, and Ag nanostructures are precipitated at the tip end of the needle-shaped body. A probe for tip-enhanced Raman scattering in which the Ag nanostructures are fixed to the tip end of the needle-shaped body is manufactured. The sizes and shapes of the Ag nanostructures can be controlled properly by adjusting the concentration of the aqueous silver nitride solution and the time during which the cantilever is dipped into the aqueous silver nitride solution.

Abstract: A calibration curve setting method used at the time of quantitatively analyzing specific components in a drug by a transmission Raman spectrum, the method comprising the steps of: obtaining respective transmission Raman spectra of a plurality of different wave number ranges including Raman hands corresponding to the specific components of a plurality of known drugs of which concentrations or amounts of the specific components are known and the concentrations or the amounts are different from each other; calculating candidate calibration curves which are candidates for calibration curves used for the quantitative analysis respectively from a plurality of transmission. Raman spectra in each of the wave number ranges; and using the most probable candidate calibration curve as a calibration curve for the quantitative analysis of the specific components, among the respective candidate calibration curves.

Abstract: A needle-shaped body protrudes from a cantilever made of Si. Furthermore, the rear face of the cantilever is coated with aluminum having a Fermi level higher than that of Si. The cantilever is dipped into an aqueous silver nitride solution containing the ions of Ag serving as a second metal. The electrons of Si flow out to the aqueous silver nitride solution due to the existence of the aluminum, and Ag nanostructures are precipitated at the tip end of the needle-shaped body. A probe for tip-enhanced Raman scattering in which the Ag nanostructures are fixed to the tip end of the needle-shaped body is manufactured. The sizes and shapes of the Ag nanostructures can be controlled properly by adjusting the concentration of the aqueous silver nitride solution and the time during which the cantilever is dipped into the aqueous silver nitride solution.

Abstract: A method of measuring a stress component in a short period of time in a nondestructive manner and a stress component measurement device that includes a stress component comparison section that compares a Raman spectrum L obtained in a predetermined area W1 of a reference specimen W to which a given stress component is applied with the stress component, a correlation data production section that produces correlation data indicating a correlation between the Raman spectrum L and the stress component by the use of a multivariate analysis method based on the comparison results conducted by the stress component comparison section. The comparison is conducted multiple times on different predetermined areas W1.

Abstract: An object of this invention is to provide stress measurement method that is stress of the measuring object nondestructively in a short period of time.

Abstract: An object of this invention is to provide a method that can measure a stress component in a short period of time in a nondestructive manner.