Abstract: A switch unit is connected between a first node electrically connected to a power source and a second node electrically connected to a load circuit which receives power supplied from the power source. As a current suppression element is connected to the switch unit in parallel. A fault sensing unit senses abnormality in an electrically conducting circuit formed by electrically interconnecting the first node and the second node. When a closing operation of a switchgear is performed, a switching command unit conducts an abnormality diagnosis in a first state in which the switch unit is controlled so that an impedance between the first node and the second node has a first value, and when no abnormal state is sensed in the abnormality diagnosis, the switching command unit controls the switch unit to establish a second state in which the impedance is equal to or smaller than the first value.

Abstract: Ridging caused when handling steel containing a large amount of alloying elements such as Si and Al in a low-speed hot rolling process is suppressed. A method of producing a hot-rolled steel sheet for a non-oriented electrical steel sheet comprises: producing a steel slab having a certain chemical composition and a thickness of 50 mm to 200 mm by continuous casting; conveying the steel slab to a hot rolling line while maintaining a surface temperature of the steel slab at 800° C. or more; and performing hot rolling in which the steel slab is sequentially subjected to rough rolling, reheating treatment, and finish rolling in the hot rolling line to obtain a hot-rolled steel sheet, wherein the hot rolling is performed under specific conditions.

Abstract: In a time synchronization communication system, a time synchronization end station remotely controls a time synchronization bridge. After transmitting a first message to the time synchronization bridge, the time synchronization end station transmits a second message to the time synchronization bridge on condition that the time synchronization end station has acquired, from the time synchronization bridge, the time held in a time holding section as the first message is received by the time synchronization bridge.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a herboxidiene splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. The herboxidiene itself is also claimed. Further claims are directed to its use, and to the use of a neoantigen, generated by the herboxidiene or its ADC, or a vaccine against this neoantigen.

Abstract: The carcinostatic agent of the present invention is an extract from seeds of Aeginetia indica and has interleukin-2 and interferon-.gamma. inducing potency. As shown in FIG. 1, all of the mice, to which this extract was not given, (.DELTA.) died from tumor (6 mice). In contrast, in the mice, to which the extract was given by 0.6 mg/kg (.quadrature.), 1.2 mg/kg (+), and 2.5 mg/kg ( ) intraperitoneally once in every two days from the day of tumor grafting, all mice showed increase in the survival rate. Thus, the extract exhibits excellent carcinostatic effect.