Abstract: This application relates to the artificial intelligence (AI) field, and specifically, to a voice quality enhancement method and a related device. The method includes: after a PNR mode is enabled, obtaining a noisy voice signal and target voice-related data, where the noisy-carrying voice signal includes a voice signal of a target user and an interfering noise signal, and the target voice-related data indicates a voice feature of the target user; and performing noise reduction on the noisy voice signal based on the target voice-related data by using a trained voice noise reduction model to obtain a noise-reduced voice signal of the target user, where the voice noise reduction model is implemented based on a neural network. In embodiments of this application, voice of a target person can be enhanced, and interference can be suppressed.

Abstract: The present disclosure relates to an epitaxial structure of a semiconductor device, a device, and a method of manufacturing the epitaxial structure. The epitaxial structure includes a substrate, and a first semiconductor layer, located on the substrate, the first semiconductor layer including buffer layers, the buffer layers at least including a first buffer layer, a second buffer layer, and a third buffer layer which are arranged in layers, and the second buffer layer being located between the first buffer layer and the third buffer layer, wherein the second buffer layer is doped with iron impurities, and the first buffer layer and the third buffer layer are not actively doped with iron impurities, and concentration of iron impurities of the second buffer layer satisfies a first preset range.

Abstract: A class of bifunctional compounds for targeting and degrading an IRAK4 kinase protein, a pharmaceutical composition and a preparation method therefor are provided. The compounds not only effectively inhibits and/or degrades the IRAK4 kinase protein in cells, but also effectively inhibit the production of IL-6 by immune cells, and has good degradation selectivity. The compounds can be used in the preparation of a drug for treating and/or preventing IRAK4-mediated related diseases or conditions, such as cancer, immunological diseases and inflammatory diseases.

Abstract: A class of indazole derivatives targeting an IRAK4 kinase protein for degradation, and a preparation method therefor and the use thereof are provided. In particular, the compound of formula I, a preparation method therefor, and a pharmaceutical composition thereof and the use thereof are presented. The compound can significantly degrade the IRAK4 kinase protein in cells and can be used as a drug for the treatment and/or prevention of related diseases or conditions mediated by the IRAK4, such as cancers, immune diseases, and inflammatory diseases.

Abstract: Embodiments of the present disclosure provide an epitaxial structure of a semiconductor device and a method of manufacturing the same. The epitaxial structure includes a substrate, and an epitaxial layer located on a side of the substrate, the epitaxial layer including a nucleation layer located on a side of the substrate and a buffer layer located on a side of the nucleation layer away from the substrate, wherein a thickness of the buffer layer is inversely proportional to a thickness of the nucleation layer.

Abstract: Provided are a testing apparatus for a pile end settlement of a rock-socketed driven PHC tube pile and an installation method thereof. The testing apparatus comprises a PHC tube pile, two measuring tubes, a cross pile tip, a pile tip steel plate, a fixer fixed in the PHC tube pile, a perforated steel plate located at a pile top of the PHC tube pile and a jack pressed on the perforated steel plate. The two measuring tubes are symmetrically arranged, the fixer is provided with two first measuring tube outlet holes, and the two measuring tubes respectively pass through the first measuring tube outlet holes of the fixer; and the perforated steel plate is also provided with two second measuring tube outlet holes, and the two measuring tubes respectively pass through the second measuring tube outlet holes of the perforated steel plate. (FIG.

Abstract: The present disclosure relates a compound as an IRAK inhibitor. Specifically, the present disclosure provides a compound of formula I, or a cis-trans isomer, an optical isomer, a racemate, a pharmaceutically acceptable salt, a prodrug, a deuterated derivative thereof, a hydrate or a solvate thereof. The compounds disclosed herein have potent inhibitory effects on IRAK and thus have therapeutic effect on IRAK-related diseases.

Abstract: A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders.

Abstract: Surface-functionalized nano structures, arrays of the nanostructures, and method for using the arrays in surfaced-enhanced spectroscopy and dielectric sensing applications, such as surface-enhanced infrared absorption spectroscopy, are provided. The nanostructures are functionalized with specific binding moieties that are bound to the nanostructures via phosphonic acid linkers.

Abstract: A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders.

Abstract: Surface-functionalized nano structures, arrays of the nanostructures, and method for using the arrays in surfaced-enhanced spectroscopy and dielectric sensing applications, such as surface-enhanced infrared absorption spectroscopy, are provided. The nanostructures are functionalized with specific binding moieties that are bound to the nanostructures via phosphonic acid linkers.

Abstract: A network device and a vertical interface are disclosed. The network device includes a panel (31), a printed circuit board PCB (32), and N vertical interfaces (33). The vertical interface is an interface whose width is less than a height. The panel is connected to the PCB, and the panel includes N vertical openings, where N is greater than or equal to 2. Each of the N vertical interfaces includes a housing (331), a connection component (332), and a connector (333). The housing is configured to accommodate the vertical interface into the panel by using one of the N vertical openings on the panel. The connection component is configured to connect the vertical interface to the PCB. The connector is configured to transmit a signal to the PCB by using the connection component.

Abstract: Anodes, solar cells utilizing said anodes, and methods of manufacturing the same are disclosed. More specifically, the anodes disclosed herein may comprise a substrate made from a conducting material, and further comprise an array of nanowires projecting from the substrate. Solar cells that utilize an anode disclosed herein include nanoparticle-based cells and organic photovoltaic cells. The nanoparticle-based cells include dye sensitized solar cells and quantum dot/rod sensitized solar cells. The organic photovoltaic cells can include polymer solar cells, and hybrid organic/inorganic cells utilizing a combination of nanoparticle based and polymer solar cells.