Patents by Inventor Shizhong Zhang
Shizhong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230310401Abstract: Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, an amphiphilic polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, and a hydrophilic polymer of polyoxyethylene-polyoxypropylene glycol block copolymer. The mass percentage of the active pharmaceutical ingredient in the pharmaceutical composition is 5 wt % to 60 wt %; the mass percentage of the amphiphilic polymer in the pharmaceutical composition is 3 wt % to 40 wt %; and the mass percentage of the hydrophilic polymer in the pharmaceutical composition is 10 wt % to 90 wt %. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.Type: ApplicationFiled: June 9, 2023Publication date: October 5, 2023Inventors: Liang Chang DONG, Shizhong ZHANG, Yan JIAO, Danyong ZHANG, Wenfang ZHAO, Jingmin SHI
-
Patent number: 11707455Abstract: Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and a amphiphilic polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The mass ratio of the two is 1:0.23 to 1:3. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.Type: GrantFiled: November 27, 2018Date of Patent: July 25, 2023Assignee: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang Dong, Shizhong Zhang, Yan Jiao, Danyong Zhang, Wenfang Zhao, Jingmin Shi
-
Patent number: 11635359Abstract: An instrument and method for mechanical properties in situ testing of materials under a high temperature and complex mechanical loads are provided. The instrument includes: a support frame module used to provide a stable support and an effective vibration isolation for each functional module of the instrument; a high-frequency fatigue load applying module used to apply a high-frequency fatigue load on a tested sample; a static-dynamic mechanical load applying module used to apply a combination of static-dynamic tension/compression/bending loads on the tested sample; a high/low temperature applying module used to apply a variable temperature environment from a low temperature to a high temperature on the tested sample; and an in-situ monitoring module that may integrate a surface deformation damage measurement assembly, a three-dimensional strain measurement assembly, a microstructure measurement assembly, and an internal damage detection assembly according to a practical testing requirement.Type: GrantFiled: February 17, 2020Date of Patent: April 25, 2023Assignee: JILIN UNIVERSITYInventors: Hongwei Zhao, Jiucheng Zhao, Shizhong Zhang, Lixia Xu, Jie Wan, Xu Jing, Daqing Zhao, Zhenzhang Zhao, Liming Zhou, Yuming Fang, Yu An Mou
-
Publication number: 20220341829Abstract: An instrument and method for mechanical properties in situ testing of materials under a high temperature and complex mechanical loads are provided. The instrument includes: a support frame module used to provide a stable support and an effective vibration isolation for each functional module of the instrument; a high-frequency fatigue load applying module used to apply a high-frequency fatigue load on a tested sample; a static-dynamic mechanical load applying module used to apply a combination of static-dynamic tension/compression/bending loads on the tested sample; a high/low temperature applying module used to apply a variable temperature environment from a low temperature to a high temperature on the tested sample; and an in-situ monitoring module that may integrate a surface deformation damage measurement assembly, a three-dimensional strain measurement assembly, a microstructure measurement assembly, and an internal damage detection assembly according to a practical testing requirement.Type: ApplicationFiled: February 17, 2020Publication date: October 27, 2022Applicant: Jilin UniversityInventors: Hongwei ZHAO, Jiucheng ZHAO, Shizhong ZHANG, Lixia XU, Jie WAN, Xu JING, Daqing ZHAO, Zhenzhang ZHAO, Liming ZHOU, Yuming FANG, Yu An MOU
-
Publication number: 20220257471Abstract: A drug accommodating device of a solid oral formulation and an oral administration and delivery apparatus comprising same. The drug accommodating device comprises a filtering component and a supporting component; the filtering component and the supporting component cooperate with each other to form a space used for bearing drug particles or multiple pills; the filtering component has one or more pore channels allowing a liquid to pass; the pore channels are distributed in the filtering component in an up-down intricate intersection mode; alternatively, a water-soluble polymer material layer is provided on the filtering component.Type: ApplicationFiled: March 12, 2020Publication date: August 18, 2022Inventors: Liang Chang DONG, Yang LEI, Gang WU, Shizhong ZHANG, Jingmin SHI, Xishan CHEN
-
Patent number: 11328926Abstract: The present invention relates to the field of chemical industry, and discloses organosilicone micro-mesoporous ultra-low dielectric thin films and preparation methods therefor. A structural formula of a POSS-based organosilane precursor in the thin film is as follows: where n is 12, 16, 18, 20, or 22, and X is CH3 or CH2CH3. The preparation method includes the following steps: dissolving a certain amount of the POSS-based precursor in an organic solvent at a room temperature; adding an appropriate amount of a photoacid generator, after uniformly stirring, spraying a mixed liquid to form a film on a substrate; placing the substrate under a light-emitting diode lamp for irradiating for a preset time after the organic solvent is completely evaporated; then placing the substrate in N,N-dimethylformamide for undergoing a transesterification reaction with fluoroalkyl alcohol for 24-72 h; and washing and drying to obtain the organosilicone micro-mesoporous ultra-low dielectric thin film.Type: GrantFiled: October 9, 2018Date of Patent: May 10, 2022Assignee: HUAIYIN INSTITUTE OF TECHNOLOGYInventors: Lingli Ni, Yongtao Liu, Tao Xie, Minhua Xu, Zhitian Chen, Peng Chai, Xiaoyan Gao, Liang Dong Feng, Shizhong Zhang
-
Publication number: 20210369695Abstract: Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and an polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The mass ratio of the two is 1:0.23 to 1:3. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.Type: ApplicationFiled: November 27, 2018Publication date: December 2, 2021Applicant: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang DONG, Shizhong ZHANG, Yan JIAO, Danyong ZHANG, Wenfang ZHAO, Jingmin SHI
-
Publication number: 20210175074Abstract: The present invention relates to the field of chemical industry, and discloses organosilicone micro-mesoporous ultra-low dielectric thin films and preparation methods therefor. A structural formula of a POSS-based organosilane precursor in the thin film is as follows: where n is 12, 16, 18, 20, or 22, and X is CH3 or CH2CH3. The preparation method includes the following steps: dissolving a certain amount of the POSS-based precursor in an organic solvent at a room temperature; adding an appropriate amount of a photoacid generator, after uniformly stirring, spraying a mixed liquid to form a film on a substrate; placing the substrate under a light-emitting diode lamp for irradiating for a preset time after the organic solvent is completely evaporated; then placing the substrate in N,N-dimethylformamide for undergoing a transesterification reaction with fluoroalkyl alcohol for 24-72 h; and washing and drying to obtain the organosilicone micro-mesoporous ultra-low dielectric thin film.Type: ApplicationFiled: October 9, 2018Publication date: June 10, 2021Inventors: Lingli NI, Yongtao LIU, Tao XIE, Minhua XU, Zhitian CHEN, Peng CHAI, Xiaoyan GAO, Liang Dong FENG, Shizhong ZHANG
-
Patent number: 10809169Abstract: A system for in-situ testing of mechanical properties of materials in static and dynamic load spectra, that includes: an Arcan biaxial clamping subsystem, a press-in test subsystem, a biaxial fatigue test subsystem, a biaxial pre-tension loading subsystem, a signal detection subsystem, and a support and adjustment subsystem. A combined guide mechanism in the Arcan biaxial clamping subsystem is rigidly connected to a guide mechanism support block, an x-direction three sensor base and a y-direction force sensor base in the support and adjustment subsystem by threaded connections, respectively. A laser transmitter, a voice coil motor and a laser receiver in the press-in test subsystem are rigidly connected to a two-degree-of-freedom electric moving platform for the laser transmitter, a two-degree-of-freedom electric moving platform for the voice coil motor and a two-degree-of-freedom electric moving platform for the laser receiver in the support and adjustment subsystem by threaded connections, respectively.Type: GrantFiled: October 12, 2016Date of Patent: October 20, 2020Assignee: JILIN UNIVERSITYInventors: Zhichao Ma, Hongwei Zhao, Luquan Ren, Shizhong Zhang, Jingshi Dong, Zunqiang Fan, Daining Fang, Jingchun Ma, Yongmao Pei, Qixun Zhang, Hui Fan, Qingwei Zhuang
-
Publication number: 20200124510Abstract: A system for in-situ testing of mechanical properties of materials in static and dynamic load spectra, that includes: an Arcan biaxial clamping subsystem, a press-in test subsystem, a biaxial fatigue test subsystem, a biaxial pre-tension loading subsystem, a signal detection subsystem, and a support and adjustment subsystem. A combined guide mechanism in the Arcan biaxial clamping subsystem is rigidly connected to a guide mechanism support block, an x-direction force sensor base and a y-direction force sensor base in the support and adjustment subsystem by threaded connections, respectively. A laser transmitter, a voice coil motor and a laser receiver in the press-in test subsystem are rigidly connected to a two-degree-of-freedom electric moving platform for the laser transmitter, a two-degree-of-freedom electric moving platform for the voice coil motor and a two-degree-of-freedom electric moving platform for the laser receiver in the support and adjustment subsystem by threaded connections, respectively.Type: ApplicationFiled: October 12, 2016Publication date: April 23, 2020Applicant: JILIN UNIVERSITYInventors: Zhichao Ma, Hongwei Zhao, Luquan Ren, Shizhong Zhang, Jingshi Dong, Zunqiang Fan, Daining Fang, Jingchun Ma, Yongmao Pei, Qixun Zhang, Hui Fan, Qingwei Zhuang
-
Patent number: 10444130Abstract: Provided are a material in-situ test device and method under multi-load and multi-physical field coupled service conditions. The device is composed of a precise six-degree-of-freedom composite load applying module, a precise torsion module, a precise indentation module, a clamp module and a control module which work together to complete a composite-load and multi-physical field coupled experiment, and is integrated with a digital speckle strain measurement and infrared thermal imaging module and a microscope observation module, so as to carry out in-situ observation and quantitative characterization on material deformation behaviors and damage mechanism phenomena in a composite-load and multi-physical field loading process. For example, loading methods of “cantilever type pure bending, cantilever type tension/compression-torsion, and cantilever type bending-torsion”, etc. can realize the loading of composite load.Type: GrantFiled: September 24, 2015Date of Patent: October 15, 2019Assignee: JILIN UNIVERSITYInventors: Hongwei Zhao, Shizhong Zhang, Luquan Ren, Ning Li, Xiaohang Dai, Shunbo Wang, Zhanwei Huo, Yang Liu, Daining Fang, Yongmao Pei
-
Patent number: 10259766Abstract: A preparation method for 2,3-pentanedione, including the steps of adding one or both of 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone into water and conducting mixing, and introducing ozone at the temperature of 3-20° C. for a reaction to obtain 2,3-pentanedione. The synthesis process of the present invention uses ozone for oxidizing a mixture containing 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone, acetic acid is used as a cocatalyst, reaction conditions are mild, the operation process is simple, the product yield is high, and the cost is low.Type: GrantFiled: December 7, 2018Date of Patent: April 16, 2019Assignee: HUAIYIN INSTITUTE OF TECHNOLOGYInventors: Lei He, Qiuyue Huang, Kun Hong, Xiufang Zhu, Jiadong Zhang, Shan Yun, Tan Guo, Huaju Li, Chaoyu Wang, Yanxing Li, Shizhong Zhang, Ying Xu, Mengxin Song, Miao Pan
-
Publication number: 20190106370Abstract: A preparation method for 2,3-pentanedione, including the steps of adding one or both of 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone into water and conducting mixing, and introducing ozone at the temperature of 3-20° C. for a reaction to obtain 2,3-pentanedione. The synthesis process of the present invention uses ozone for oxidizing a mixture containing 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone, acetic acid is used as a cocatalyst, reaction conditions are mild, the operation process is simple, the product yield is high, and the cost is low.Type: ApplicationFiled: December 7, 2018Publication date: April 11, 2019Inventors: Lei HE, Qiuyue HUANG, Kun HONG, Xiufang ZHU, Jiadong ZHANG, Shan YUN, Tan GUO, Huaju LI, Chaoyu WANG, Yanxing LI, Shizhong ZHANG, Ying XU, Mengxin SONG, Miao PAN
-
Publication number: 20180180521Abstract: Provided are a material in-situ test device and method under multi-load and multi-physical field coupled service conditions. The device is composed of a precise six-degree-of-freedom composite load applying module, a precise torsion module, a precise indentation module, a clamp module and a control module which work together to complete a composite-load and multi-physical field coupled experiment, and is integrated with a digital speckle strain measurement and infrared thermal imaging module and a microscope observation module, so as to carry out in-situ observation and quantitative characterization on material deformation behaviours and damage mechanism phenomena in a composite-load and multi-physical field loading process. For example, loading methods of “cantilever type pure bending, cantilever type tension/compression-torsion, and cantilever type bending-torsion”, etc. can realize the loading of composite load.Type: ApplicationFiled: September 24, 2015Publication date: June 28, 2018Inventors: Hongwei ZHAO, Shizhong ZHANG, Luquan REN, Ning LI, Xiaohang DAI, Shunbo WANG, Zhanwei HUO, Yang LIU, Daining FANG, Yongmao PEI
-
Patent number: 7695817Abstract: A thermally conductive grease includes (A) a polyorganosiloxane having a viscosity less than 50 cSt (mm2/s) at 25° C. and (B) a thermally conductive filler. The thermally conductive grease is useful as a thermal interface material for electronic devices.Type: GrantFiled: September 16, 2004Date of Patent: April 13, 2010Assignee: Dow Corning CorporationInventors: Zuchen Lin, Shizhong Zhang, Mark Fisher
-
Publication number: 20060292840Abstract: A thermally conductive grease includes (A) a polyorganosiloxane having a viscosity less than 50 cSt (mm2/s) at 25° C. and (B) a thermally conductive filler. The thermally conductive grease is useful as a thermal interface material for electronic devices.Type: ApplicationFiled: September 16, 2004Publication date: December 28, 2006Applicant: DOW CORNING CORPORATIONInventors: Zuchen Lin, Shizhong Zhang, Mark Fisher
-
Patent number: 7074490Abstract: A phase change composition comprises: a matrix comprising an organofunctional silicone wax, and a thermally conductive filler. The composition can be used as a thermal interface material in electronic devices. The composition is formulated to have any desired phase change temperature.Type: GrantFiled: May 13, 2003Date of Patent: July 11, 2006Assignee: Dow Corning CorporationInventors: Qian Jane Feng, Lenin James Petroff, Diane Elizabeth Swarthout, Shizhong Zhang
-
Patent number: 6770708Abstract: This invention is directed to an elastomer composition produced by crosslinking a high molecular weight ≡Si—H containing polysiloxane and a diene, diyne or ene-yne compound in the presence of a diluent. The elastomer composition is suitable for use in forming personal care compositions.Type: GrantFiled: August 27, 2002Date of Patent: August 3, 2004Assignee: Dow Corning CorporationInventors: Donald Anthony Kadlec, Zuchen Lin, William James Schulz, Jr., Janet Mary Smith, Michael Stephen Starch, Shizhong Zhang
-
Publication number: 20040044121Abstract: This invention is directed to an elastomer composition produced by crosslinking a high molecular weight ≡Si—H containing polysiloxane and a diene, diyne or ene-yne compound in the presence of a diluent. The elastomer composition is suitable for use in forming personal care compositions.Type: ApplicationFiled: August 27, 2002Publication date: March 4, 2004Inventors: Donald Anthony Kadlec, Zuchen Lin, William James Schulz, Janet Mary Smith, Michael Stephen Starch, Shizhong Zhang
-
Publication number: 20030224186Abstract: A phase change composition comprises: a matrix comprising an organofunctional silicone wax, and a thermally conductive filler. The composition can be used as a thermal interface material in electronic devices. The composition is formulated to have any desired phase change temperature.Type: ApplicationFiled: May 13, 2003Publication date: December 4, 2003Inventors: Qian Jane Feng, Lenin James Petroff, Diane Elizabeth Swarthout, Shizhong Zhang