Patents by Inventor Shoji Kishimoto

Shoji Kishimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4572801
    Abstract: Disclosed are compounds of the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group and R.sup.2 is a hydrogen atom or an ester residue, said derivative having the (3S,4S)-configuration; and pharmaceutically acceptable salts and esters thereof.The compounds have antimicrobial and/or .beta.-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.
    Type: Grant
    Filed: May 31, 1983
    Date of Patent: February 25, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Taisuke Matsuo, deceased, Michihiko Ochiai, Shoji Kishimoto
  • Patent number: 4560508
    Abstract: 4-Cyano-2-azetidinone derivatives represented by the formula ##STR1## wherein R.sup.1 is an amino group which may be acylated or protected, X is a hydrogen atom or a methoxy group and W is a hydrogen atom or a sulfo group, and methods of producing the same, for example, as represented by ##STR2## wherein R.sup.2 is an acylated or protected amino group, Y is a halogen atom or a group having the formula --OCOR.sup.3, --SCOR.sup.3 or --S(O).sub.n --R.sup.3 (R.sup.3 being a hydrocarbyl group and n an integer 1 or 2), R.sup.4 is an amino group which may be acylated or protected and X is as defined above. Compounds [I] are useful as advantageous intermediates for the synthesis of optically active 4-substituted-2-azetidinone derivatives, and, when W=SO.sub.3 H, [I] are also useful as antimicrobial agents and as beta-lactamase inhibitors.
    Type: Grant
    Filed: December 20, 1982
    Date of Patent: December 24, 1985
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Taisuke Matsuo, deceased, Michihiko Ochiai, Shoji Kishimoto
  • Patent number: 4550105
    Abstract: Disclosed are compounds of the general formula: ##STR1## wherein R.sub.1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R.sup.4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R.sub.4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula --OR.sub.5, ##STR2## or --S--S--R.sub.5 wherein R.sub.5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof.The compounds have antimicrobial and/or .beta.-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.
    Type: Grant
    Filed: December 3, 1981
    Date of Patent: October 29, 1985
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Taisuke Matsuo, Shoji Kishimoto, Michihiko Ochiai
  • Patent number: 4440691
    Abstract: Indancarboxylic acid zinc salts of the formula: ##STR1## wherein X is a halogen atom, are novel compounds and have excellent pharmaceutical activities such as analgesic, antipyretic and antiinflammatory activities.
    Type: Grant
    Filed: March 15, 1982
    Date of Patent: April 3, 1984
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Seiji Kuzuna, Shoji Kishimoto, Tetsuya Aono
  • Patent number: 4355040
    Abstract: Novel imidazole-5-acetic acid derivatives of the formula: ##STR1## wherein R.sup.1 is lower alkyl, cycloalkyl or, phenyl which may be substituted with one to three of halogen, nitro, amino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkyl, lower alkoxyl, benzyloxyl or/and hydroxyl; X.sup.1, X.sup.2 and X.sup.3 are each hydrogen, halogen, nitro, amino, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl; Y is halogen and R.sup.2 is hydrogen or lower alkyl; provided that X.sup.1 is halogen, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl when R.sup.1 is unsubstituted or substituted phenyl only with one halogen, di(lower alkyl)amino, lower alkyl or lower alkoxyl, and its salts have hypotensive activity.
    Type: Grant
    Filed: November 5, 1980
    Date of Patent: October 19, 1982
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yoshiyasu Furukawa, Shoji Kishimoto, Kohei Nishikawa
  • Patent number: 4340598
    Abstract: Novel imidazole derivatives of the formula: ##STR1## wherein R.sup.1 is lower alkyl or, phenyl-C.sub.1-2 alkyl which may be substituted with halogen or nitro;R.sup.2 is lower alkyl, cycloalkyl or, phenyl which may be substituted with halogen, lower alkyl, lower alkoxyl or di(lower alkyl)amino,one of R.sup.3 and R.sup.4 is of the formula: --(CH.sub.2).sub.n --COR.sup.5 in the formula R.sup.5 is amino, lower alkoxyl or hydroxyl and n is integer of 0, 1 or 2,and the other is hydrogen or halogen;provided that R.sup.1 is lower alkyl or phenethyl when R.sup.3 is halogen, n is 1 and R.sup.5 is lower alkoxyl or hydroxyl, and their salts have hypotensive activity.
    Type: Grant
    Filed: November 5, 1980
    Date of Patent: July 20, 1982
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yoshiyasu Furukawa, Shoji Kishimoto, Kohei Nishikawa