Abstract: A cerium oxide nanoparticle whose surface is covered with a vinyl polymer has a heterocyclic amine skeleton such as piperazine, pyridine, imidazole, or carbazole or with a polyamide having a heterocyclic amine skeleton such as piperazine, pyridine, imidazole, or carbazole; and a decomposition method of a nucleic acid or a polypeptide by using the cerium oxide nanoparticle.

Abstract: A liquid medicine administration device for administering a liquid medicine into a living body includes: a cylindrical body defining a space; a tube housed in the space of the cylindrical body and filled with the liquid medicine; and a plunger mechanism provided movably in an axial direction with respect to the cylindrical body, the plunger mechanism including a pressing member configured to press a proximal end of the tube toward a distal end side to push out the liquid medicine. The tube is formed in a tubular shape having a discharge hole at a distal end for discharging the liquid medicine, and is compressed along an axial direction with movement of the pressing member, and is formed to be deformable toward a central axis side.

Abstract: This disclosure relates to a nucleic acid collection column that collects a nucleic acid from a liquid sample containing the nucleic acid. The nucleic acid collection column includes a sample injection portion having an opening into which the liquid sample containing the nucleic acid is injected, a support adsorption portion that houses a support for adsorbing the nucleic acid and in which the nucleic acid is adsorbed on the support, and a discharge portion that discharges a liquid passed through the support adsorption portion. The support includes aluminum oxide having a surface where a water-soluble neutral polymer is adsorbed. A space that houses the support in the support adsorption portion has a cylindrical shape, and has a volume of 0.13 ?L or more and 13.5 ?L or less. An aspect ratio (d1/d2) of the space satisfies 1.0?d1/d2<15.0.

Abstract: A cerium oxide nanoparticle is produced by adding an oxidant to a solution comprising a boron compound represented by formula (I) and a cerium (III) ion: BRn(OR?)3-n??(I) wherein n represents an integer of 0 to 2, R represents any of an alkyl group having 1 to 4 carbon atoms, a phenyl group, and a tolyl group, and R? represents any of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenyl group, and a tolyl group, and when a plurality of Rs or of R's are present, the plurality of Rs or of R's are optionally the same or different.

Abstract: A method utilizes an aluminum oxide support with a water-soluble neutral polymer adsorbed on a surface of the aluminum oxide support and is aimed to collect nucleic acids from a body fluid sample. The method includes a step of adsorbing nucleic acids on the support in the presence of a chaotropic agent and a step of adding a solution containing an anionic surfactant to the nucleic acid-adsorbed support.

Abstract: A cerium oxide nanoparticle is produced by mixing a solution of an aromatic heterocyclic compound having no substituent or at least one substituent selected from the group consisting of a methyl group, an ethyl group, an amino group, an aminomethyl group, a monomethylamino group, a dimethylamino group, and a cyano group and containing 2 to 8 carbon atoms and 1 to 4 nitrogen atoms in a ring structure of the aromatic heterocyclic compound, with a solution containing a cerium (III) ion or with a cerium (III) salt, followed by addition of an oxidant.

Abstract: A dispersion solution contains a complex of cerium oxide nanoparticle with protein in which a hydrodynamic diameter and zeta potential of the protein are maintained. The dispersion solution is produced by mixing a solution containing the protein with a solution containing a cerium (III) ion or with a cerium (III) salt followed by adding an oxidizing agent thereto.

Abstract: A method of detecting a nucleic acid including a) mixing a solution containing a carboxylic acid and/or a salt thereof, a cerium oxide support and a sample containing a nucleic acid to adsorb said nucleic acid to said cerium oxide support, b) separating said cerium oxide support on which said nucleic acid was adsorbed from the mixture obtained in a), c) collecting said nucleic acid by adding an eluent to said cerium oxide support on which said nucleic acid was adsorbed and separated in b), and d) detecting said nucleic acid collected in c) by a hybridization reaction or a nucleic acid amplification reaction.

Abstract: A method of collecting a nucleic acid from a sample containing a nucleic acid using a support of aluminum oxide having a surface where a water-soluble neutral polymer is adsorbed, the method including steps a to c: step a: a step of bringing the support into contact with the sample containing a nucleic acid to adsorb the nucleic acid on the support; step b: a step of bringing the support on which the nucleic acid is adsorbed into contact with a solution A containing 1 mM or more and 40 mM or less of a chelating agent; and step c: after the step b, a step of bringing the support on which the nucleic acid is adsorbed into contact with a solution B containing 50 mM or more of a chelating agent to elute the nucleic acid.

Abstract: A cerium oxide nanoparticle whose surface is covered with a vinyl polymer has a heterocyclic amine skeleton such as piperazine, pyridine, imidazole, or carbazole or with a polyamide having a heterocyclic amine skeleton such as piperazine, pyridine, imidazole, or carbazole; and a decomposition method of a nucleic acid or a polypeptide by using the cerium oxide nanoparticle.

Abstract: An infusion pump includes: a main body configured to have an infusion tube fixed thereto, wherein the main body includes: a first fixing unit, a second fixing unit that is movable between (i) a pressing position in which the infusion tube is pressed against the first fixing unit, and (ii) a release position in which the pressing of the infusion tube against the first fixing unit is released, by being rotated with respect to a rotary shaft, an urging unit configured to urge the second fixing unit toward the release position, the urging unit comprising an urging member mounted on the rotary shaft, a transmission unit configured to transmit a signal toward the infusion tube sandwiched between the first fixing unit and the second fixing unit, and a reception unit configured to receive the signal transmitted from the transmission unit.

Abstract: A nucleic acid collection column collects a nucleic acid from a liquid sample containing the nucleic acid. The nucleic acid collection column includes a sample injection portion having an opening into which the liquid sample containing the nucleic acid is injected, a support adsorption portion that houses a support for adsorbing the nucleic acid and in which the nucleic acid is adsorbed on the support, and a discharge portion that discharges a liquid passed through the support adsorption portion. The support includes aluminum oxide having a surface where a water-soluble neutral polymer is adsorbed. A space that houses the support in the support adsorption portion has a cylindrical shape, and has a volume of 0.13 ?L or more and 13.5 ?L or less. An aspect ratio (d1/d2) of the space satisfies 1.0?d1/d2<15.0.

Abstract: A method of collecting a nucleic acid(s) from a biological sample includes step a) mixing an aluminum oxide support with a water-soluble neutral polymer adsorbed on a surface thereof and a solution containing a nucleic acid(s), thereby adsorbing the nucleic acid(s) to the support; step b) separating the support on which the nucleic acid(s) is/are adsorbed from the solution mixed in step a); and step c) collecting the nucleic acid(s) by adding an eluent to the support on which the nucleic acid(s) is/are adsorbed and which is separated in step b).

Abstract: An amplitude of current ripples on a primary side of a power supply device that uses a plurality of transformers is reduced. A driving power supply device (7) that supplies electric power to a plurality of drive circuits (2) that individually drive switching elements (3) of an inverter (10) includes a plurality of transformers (L) having secondary-side coils (Ls) which are individually connected to the respective corresponding drive circuits (2); a plurality of transformer driving units (5) each including a driving switching element (M) that controls supply of electric power to a primary-side coil (Lp); and a power supply control device (6) that provides transformer drive signals (MG) for driving the transformer driving units (5). The power supply control device (6) drives the transformer driving units (5) by transformer drive signals (MG) having different phases.

Abstract: A prefilled syringe is disclosed, which includes: a liquid medicine; a barrel including a cylindrical body section containing the liquid medicine, and a nozzle section provided on a distal end side of the body section that discharges the liquid medicine; a cap sealing a distal end opening; a gasket sliding on an inner circumferential surface of the body section; a plunger that can be mounted to the gasket; and an RFID tag having a fixed location with respect to the outer circumferential surface and has an antenna and a memory, the antenna being structured from an antenna wire wound in a rectangle, an outer diameter of the body section being 14 mm to 33 mm, the maximum circumferential length of the antenna is 9 mm to 25 mm, and the circumferential length of the outer circumferential surface is 2.0 times to 7.0 times the maximum circumferential length of the antenna.

Abstract: A method utilizes an aluminum oxide support with a water-soluble neutral polymer adsorbed on a surface of the aluminum oxide support and is aimed to collect nucleic acids from a body fluid sample. The method includes a step of adsorbing nucleic acids on the support in the presence of a chaotropic agent and a step of adding a solution containing an anionic surfactant to the nucleic acid-adsorbed support.

Abstract: An amplitude of current ripples on a primary side of a power supply device that uses a plurality of transformers is reduced. A driving power supply device (7) that supplies electric power to a plurality of drive circuits (2) that individually drive switching elements (3) of an inverter (10) includes a plurality of transformers (L) having secondary-side coils (Ls) which are individually connected to the respective corresponding drive circuits (2); a plurality of transformer driving units (5) each including a driving switching element (M) that controls supply of electric power to a primary-side coil (Lp); and a power supply control device (6) that provides transformer drive signals (MG) for driving the transformer driving units (5). The power supply control device (6) drives the transformer driving units (5) by transformer drive signals (MG) having different phases.

Abstract: A method of detecting a nucleic acid including a) mixing a solution containing a carboxylic acid and/or a salt thereof, a cerium oxide support and a sample containing a nucleic acid to adsorb said nucleic acid to said cerium oxide support, b) separating said cerium oxide support on which said nucleic acid was adsorbed from the mixture obtained in a), c) collecting said nucleic acid by adding an eluent to said cerium oxide support on which said nucleic acid was adsorbed and separated in b), and d) detecting said nucleic acid collected in c) by a hybridization reaction or a nucleic acid amplification reaction.

Abstract: A method of collecting cell-free DNA from a body fluid sample includes step a) of mixing an aluminum oxide support including a water-soluble neutral polymer adsorbed on a surface thereof with the body fluid sample to adsorb the cell-free DNA onto the support, step b) separating the support on which the cell-free DNA was adsorbed from the mixture mixed in the step a), and step c) collecting the cell-free DNA by adding an eluent to the support on which the cell-free DNA was adsorbed and which was separated in the step b).

Abstract: A method of producing a chemical product includes culturing a microorganism with a fermentation feedstock containing cane molasses as a main component; filtering the resulting culture liquid through a separation membrane to recover a filtrate which contains the chemical product and from which the microorganism has been separated; retaining or returning an unfiltered liquid containing the microorganism, in or to the culture liquid; and adding an additional fermentation feedstock to the culture liquid to carry out continuous fermentation; in which the microorganism cultured causes a centrifugal supernatant of the culture liquid to contain particles having an average particle diameter of 100 nm or more.