Abstract: A range-finding device including a light-emitting device, an imaging unit, a calculator, and a controller. The image unit receives pulsed light reflected from an object within the space for a plurality of time periods in a time-division manner, electrically converts the pulsed light into an electrical signal, and accumulates electric charge of the electrical signal for each of the plurality of time periods. The calculator calculates a time difference between emission of the pulsed light and reception of the pulsed light reflected from the object based on the electric charge accumulated for each of the plurality of time periods and determine a distance to the object based on the time difference. The controller controls the timing of reception of the pulsed light for each of the plurality of time periods at the imaging unit according to an intensity of the pulsed light reflected from the object.

Abstract: A distance measurement device includes a projection optical system, a light-receiving system to receive light projected from projection optical system and reflected by an object; and a correction system to correct a difference in timing of light emission between the plurality of light sources. The projection optical system includes a plurality of light sources and a plurality of drive circuits to drive the plurality of light sources.

Abstract: A sensor includes a light source to emit a pulse light, a light receiver to receive light, emitted from the light source and reflected from an object, a range information acquisition unit to calculate information of a range to the object based on light emission timing at the light source and light reception timing at the light receiver and a speed of the pulse light emitted from the light source, and a pulse controller to control a pulse pattern of the pulse light emitted from the light source based on the range information calculated by the range information acquisition unit.

Abstract: The present invention relates to an antibody having a therapeutic effect on a tumor. That is, the invention relates to an antibody which binds to B7-H3 to exhibit an antitumor activity. An object of the invention is to provide a pharmaceutical having a therapeutic effect on a tumor. By obtaining an anti-B7-H3 antibody which binds to B7-H3 to exhibit an antitumor activity, a pharmaceutical composition for treating a tumor comprising the antibody and the like are obtained.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A plurality of pixels PD1, PD2 for detecting the phase difference are treated as a pixel group, and a slit 46, which makes incident light entering into each of the pixels of the pixel group PD1, PD2 asymmetrical, is formed in between optical elements (microlenses) 43 formed at an upper layer at the light-entering side of the pixel group PD1, PD2, and in between intermediate refractive-index layers 45. The side faces of the slit 46 are made to be light reflecting faces.

Abstract: An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.

Abstract: An input operation detection device to detect input operation input to an image includes a first and second imaging parts and a processor to detect input operation based on data acquired by the first and second imaging parts. The image is divided into first and second images. The optical axes of imaging optical systems of the first and second imaging parts intersect with the image at points on the same side as installation position sides of the corresponding imaging parts with respect to the center of the corresponding images.

Abstract: The present invention utilizes color mixings with angle dependencies from adjacent R pixels, and in the case where a subject color is red, uses first and second B pixels as phase-difference pixels, allowing for an accurate phase-difference AF based on the output signals of the first and second B pixels. Here, it is unnecessary to provide phase-difference pixels dedicated to the case where the subject color is red, and the phase difference is detected using ordinary B pixels of an imaging element. Therefore, the resolution is not sacrificed.

Abstract: Provided is an imaging device which can accurately obtain two captured image signals having a phase difference therebetween. An imaging device includes a plurality of pixels including two types of pixels, such as a first pixel that receives one of a pair of light beams which pass through different pupil regions of an imaging optical system and a second pixel that receives the other of the pair of light beams. The plurality of pixels are arranged in a square lattice shape. A light receiving region of the first pixel deviates from the center of the first pixel to the right side. A light receiving region of the second pixel deviates from the center of the second pixel to the left side.

Abstract: A solid-state imaging element includes pixel cells in which apertures of light shielding films are off-centered in opposite directions. The pixel cells includes a pixel cell which detects a R light component, a pixel cell which detects a G light component, and a pixel cell which detects a B light component. In the pixel cells, a relationship among an off-centered amount Or of the aperture in the pixel cell which detects the R light component, an off-centered amount Og of the aperture in the pixel cell which detects the G light component, and an off-centered amount Ob of the aperture in the pixel cell which detects the B light component is Or>Og>Ob.

Abstract: According to an aspect of the present invention, an input-operation detection device for detecting a user input operation performed on at least a portion of a displayed image includes; a light emitter that emits detection light, an imaging unit including an imaging optical system and an image sensor and configured to capture an image of at least one of the displayed image and the input operation, and a processing unit that detects position, at which the input operation is performed, or motion, by which the input operation is provided, based on a result of image capture output from the imaging unit. The position where optical axis of the imaging optical system intersects a display surface of the displayed image and center of the displayed image are on the same side relative to a position where the imaging unit is mounted.

Abstract: The present invention utilizes color mixings with angle dependencies from adjacent R pixels, and in the case where a subject color is red, uses first and second B pixels as phase-difference pixels, allowing for an accurate phase-difference AF based on the output signals of the first and second B pixels. Here, it is unnecessary to provide phase-difference pixels dedicated to the case where the subject color is red, and the phase difference is detected using ordinary B pixels of an imaging element. Therefore, the resolution is not sacrificed.

Abstract: A solid-state imaging element includes pixel cells in which apertures of light shielding films are off-centered in opposite directions. The pixel cells includes a pixel cell which detects a R light component, a pixel cell which detects a G light component, and a pixel cell which detects a B light component. In the pixel cells, a relationship among an off-centered amount Or of the aperture in the pixel cell which detects the R light component, an off-centered amount Og of the aperture in the pixel cell which detects the G light component, and an off-centered amount Ob of the aperture in the pixel cell which detects the B light component is Or>Og>Ob.

Abstract: In a back-illuminated solid-state image sensing element, the areas of the front surface sides of individual pixels are the same as one another, regardless of the colors of light components dispersed by filters and entering the individual pixels, and the areas of the rear surface sides of pixels which a dispersed red light component enters are larger than the areas of the rear surface sides of pixels which a green or blue light component enters.

Abstract: Provided is an imaging device which can accurately obtain two captured image signals having a phase difference therebetween. An imaging device includes a plurality of pixels including two types of pixels, such as a first pixel that receives one of a pair of light beams which pass through different pupil regions of an imaging optical system and a second pixel that receives the other of the pair of light beams. The plurality of pixels are arranged in a square lattice shape. A light receiving region of the first pixel deviates from the center of the first pixel to the right side. A light receiving region of the second pixel deviates from the center of the second pixel to the left side.

Abstract: In a back-illuminated solid-state image sensing element, the areas of the front surface sides of individual pixels are the same as one another, regardless of the colors of light components dispersed by filters and entering the individual pixels, and the areas of the rear surface sides of pixels which a dispersed red light component enters are larger than the areas of the rear surface sides of pixels which a green or blue light component enters.

Abstract: An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.

Abstract: The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.

Abstract: A solid-state imaging device comprises: a semiconductor substrate; a plurality of photoelectric conversion elements formed in a surface portion of the semiconductor substrate in the form of a two-dimensional array so as to comprise a plurality of sets, each comprising a subset of the photoelectric conversion elements arranged in one direction; charge transfer paths each formed at a side portion of the subset of the photoelectric conversion elements to cause a signal charge of the photoelectric conversion elements be read out when a readout pulse is applied and cause the signal charge which has been read out to be transferred when a transfer pulse is applied; and an electrically conductive light shielding film which is laminated on a surface of the semiconductor substrate through an insulating layer and has openings immediately above each of the photoelectric conversion elements.