Abstract: Provided is a priming method including a step of filling a priming liquid in a hollow-fiber membrane module in which hollow-fiber membranes are packed in a vessel having an inlet port, an outlet port, and a filtrate discharge port at a linear velocity of 20 cm/min or more and 550 cm/min or less through the inlet port or the outlet port in an amount of 15% or more relative to a volume of the hollow-fiber membrane module. According to the present invention, the effective filtration area at the time of cell suspension treatment is increased, and the recovery rate of cells and the filtration rate can be improved. Further, since the cell treatment can be completed while maintaining the closed environment, the obtained cells can be provided for therapeutic applications.

Abstract: In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit.

Abstract: In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit.

Abstract: In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit.

Abstract: Provided is a simple method for producing a cell concentrate (other than human blood) in a short time with neither loss of cells nor an excessive burden on cells. Included is a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and hollow fiber separation membranes provided between the cell suspension inlet port and the cell suspension outlet port, wherein the membranes have a total cross-sectional area of 0.5-1.5 cm2, the membranes have an inside membrane area of 0.2 m2 or less, the suspension is flowed inside the membranes at a linear velocity of 500-1200 cm/min, and the quotient of the division of the initial filtrate flow rate from the filtrate outlet port by the flow rate into the cell suspension inlet port is 0.4-0.7.

Abstract: Provided is a priming method including a step of filling a priming liquid in a hollow-fiber membrane module in which hollow-fiber membranes are packed in a vessel having an inlet port, an outlet port, and a filtrate discharge port at a linear velocity of 20 cm/min or more and 550 cm/min or less through the inlet port or the outlet port in an amount of 15% or more relative to a volume of the hollow-fiber membrane module. According to the present invention, the effective filtration area at the time of cell suspension treatment is increased, and the recovery rate of cells and the filtration rate can be improved. Further, since the cell treatment can be completed while maintaining the closed environment, the obtained cells can be provided for therapeutic applications.

Abstract: The present invention provides a method that allows the preparation of a cell concentrate in a short time without loss of cells and great damage on cells by simple operations. The present invention provides a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and a hollow fiber separation membrane interposed between the cell suspension inlet port and the cell suspension outlet port, wherein the hollow fiber separation membrane is provided with inner pores with an average pore size of 0.1 ?m to 10 ?m, and the quotient of the division of an initial filtrate flow rate by a linear velocity of the cell suspension flowing through the hollow fibers is 2.5 or less.

Abstract: In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit.

Abstract: Provided is a simple method for producing a cell concentrate (other than human blood) in a short time with neither loss of cells nor an excessive burden on cells. Included is a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and hollow fiber separation membranes provided between the cell suspension inlet port and the cell suspension outlet port, wherein the membranes have a total cross-sectional area of 0.5-1.5 cm2, the membranes have an inside membrane area of 0.2 m2 or less, the suspension is flowed inside the membranes at a linear velocity of 500-1200 cm/min, and the quotient of the division of the initial filtrate flow rate from the filtrate outlet port by the flow rate into the cell suspension inlet port is 0.4-0.7.

Abstract: The present invention provides a method that allows the preparation of a cell concentrate in a short time without loss of cells and great damage on cells by simple operations. The present invention provides a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and a hollow fiber separation membrane interposed between the cell suspension inlet port and the cell suspension outlet port, wherein the hollow fiber separation membrane is provided with inner pores with an average pore size of 0.1 ?m to 10 ?m, and the quotient of the division of an initial filtrate flow rate by a linear velocity of the cell suspension flowing through the hollow fibers is 2.5 or less.

Abstract: A lubricant surface coating having good lubricity and high durability, comprising (A) an urethane polymer layer comprising (a) 40 to 80% by weight of at least one component selected from an aromatic diisocyanate, an aliphatic diisocyanate and an alicyclic diisocyanate and (b) 20 to 60% by weight of a polyol having at least trifunctionality and (B) a hydrophilic polymer layer provided as the outer layer for the urethane polymer layer which comprises a polyalkylene glycol and/or a monomethoxypolyalkylene glycol; and a medical device having the surface coating.

Abstract: A pressure-sensitive adhesive sheet to be stuck to the skin which comprises a support and a pressure-sensitive adhesive layer located on the support, characterized in that the pressure-sensitive adhesive layer is formed by curing a composition containing (A) a polyoxyalkylene polymer having at least one alkenyl group per molecule, (B) a compound having hydrosilyl groups at both ends, (C) a compound having two or more hydrosilyl groups on average per molecule, and (D) a hydrosilylation catalyst. Compared with the existing pressure-sensitive adhesive sheets to be stuck to the skin, the pressure-sensitive adhesive sheet to be stuck to the skin as described above little irritates the skin and can achieve a sufficient pressure-sensitive adhesion force and a long-lasting fixation force to the skin.

Abstract: It is intended to provide a resin foam which can be preferably used for medical use, and a flexible silicone type resin foam having a water-absorbing property. The resin foam which has a low toxicity and excellent physical properties for medical use such as moisture permeability, skin compatibility and low irritation can be obtained by using a resin which has a siloxane unit and an oxyalkylene unit in its molecular structure and does not contain a unit derived from an isocyanate group. Further, the flexible silicone type resin foam having a water-absorbing property can be obtained by allowing it to have a specific resin composition and a foam structure.

Abstract: A lubricant surface coating having good lubricity and high durability, comprising (A) an urethane polymer layer comprising (a) 40 to 80% by weight of at least one component selected from an aromatic diisocyanate, an aliphatic diisocyanate and an alicyclic diisocyanate and (b) 20 to 60% by weight of a polyol having at least trifunctionality and (B) a hydrophilic polymer layer provided as the outer layer for the urethane polymer layer which comprises a polyalkylene glycol and/or a monomethoxypolyalkylene glycol; and a medical device having the surface coating.

Abstract: In order to eliminate limitation upon the frequency of a carrier wave from externally, this IC chip for identification includes: a power supply section which receives this carrier wave from outside and creates an internal power supply; a clock signal generation section for read out which generates an internal clock signal for read out based upon a clock signal pulse which is superimposed upon an optical signal from externally; a memory section; and an output section which serially reads out data in the memory section according to the internal clock signal for read out, and load modulates the carrier wave from outside based thereupon.

Abstract: Restrictions on the frequency of a carrier signal are removed. This invention comprises a power section for receiving the carrier signal and creating an internal voltage, a clock-generating section for creating an internal clock based on a clock pulse that is carried by the carrier signal, a memory section, a writing section for storing data that is carried on an optical signal in the memory section, and an output section for reading the data in the memory and load-modulating the carrier signal.

Abstract: The capacitance of a smoothing capacitor is reduced, and the size of an IC chip is minimized. A series transistor is provided on the output side of a diode which rectifies the output voltage of an antenna, and the smoothing capacitor is connected to the base of the series transistor. If the current gain of the series transistor T is ?, then the apparent capacitance of the smoothing capacitor C2 is multiplied by ?.

Abstract: In order to eliminate limitation upon the frequency of a carrier wave from externally, this IC chip for identification includes: a power supply section which receives this carrier wave from outside and creates an internal power supply; a clock signal generation section for read out which generates an internal clock signal for read out based upon a clock signal pulse which is superimposed upon an optical signal from externally; a memory section; and an output section which serially reads out data in the memory section according to the internal clock signal for read out, and load modulates the carrier wave from outside based thereupon.

Abstract: Restrictions on the frequency of a carrier signal are removed. This invention comprises a power section for receiving the carrier signal and creating an internal voltage, a clock-generating section for creating an internal clock based on a clock pulse that is carried by the carrier signal, a memory section, a writing section for storing data that is carried on an optical signal in the memory section, and an output section for reading the data in the memory and load-modulating the carrier signal.