Patents by Inventor Shujaath Mehdi

Shujaath Mehdi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120202795
    Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Application
    Filed: April 18, 2012
    Publication date: August 9, 2012
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Philip M. WEINTRAUB, Paul R. EASTWOOD, Shujaath MEHDI, David W. STEFANY, Kwon Yon MUSICK, Neil MOORCROFT, Sungtaek LIM, John Z. JIANG, Hartmut RUTTEN, Stefan PEUKERT, Uwe SCHWAHN
  • Patent number: 8173682
    Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: May 8, 2012
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Philip M. Weintraub, Paul R. Eastwood, Shujaath Mehdi, David W. Stefany, Kwon Yon Musick, Neil Moorcroft, Sungtaek Lim, John Z. Jiang, Hartmut Rutten, Stefan Peukert, Uwe Schwahn
  • Patent number: 8008491
    Abstract: The present invention relates to a series of substituted aza-indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: August 30, 2011
    Assignee: Aventis Pharmaceuticals, Inc.
    Inventors: John Ziqi Jiang, Jack Roger Koehl, Shujaath Mehdi, Neil Moorcroft, Kwon Yon Musick, Philip Marvin Weintraub, Paul Robert Eastwood
  • Publication number: 20100143937
    Abstract: The present invention provides methods for the detection of agents that modify the activity of the N-acylphosphatidylethanolamine-hydrolysing phospholipase D (NAPE-PLD) enzyme or the Alpha/beta-hydrolase-4 (Abh4) enzyme. The disclosed methods are configured in an assay format amenable to high throughput screening applications.
    Type: Application
    Filed: May 29, 2008
    Publication date: June 10, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Jane Vivienne Peppard, Shujaath Mehdi, Zhuyin Li, Mei S. Duguid
  • Publication number: 20080255350
    Abstract: The present invention relates to a series of substituted aza-indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Application
    Filed: June 17, 2008
    Publication date: October 16, 2008
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: John Z. JIANG, Jack Roger KOEHL, Shujaath MEHDI, Neil MOORCROFT, Kwon Yon MUSICK, Philip Marvin WEINTRAUB, Paul Robert EASTWOOD
  • Patent number: 7405300
    Abstract: The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: July 29, 2008
    Assignee: Aventis Pharmaveuticals Inc.
    Inventors: John Z. Jiang, Jack Roger Koehl, Shujaath Mehdi, Neil David Moorcroft, Kwon Yon Musick, Philip Marvin Weintraub, Paul Robert Eastwood
  • Publication number: 20070032489
    Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Application
    Filed: September 26, 2006
    Publication date: February 8, 2007
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Philip Weintraub, Paul Eastwood, Shujaath Mehdi, David Stefany, Kwon Musick, Neil Moorcroft, Sungtaek Lim, John Jiang, Hartmut Rutten, Stefan Peukert, Uwe Schwahn
  • Publication number: 20050054631
    Abstract: The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Application
    Filed: September 1, 2004
    Publication date: March 10, 2005
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: John Jiang, Jack Koehl, Shujaath Mehdi, Neil Moorcroft, Kwon Musick, Philip Weintraub, Paul Eastwood
  • Publication number: 20040115710
    Abstract: Provided herein is a novel and useful method for determining whether a compound or agent decreases or inhibits the activity of a poly(ADP-ribose)-polymerase (PARP).
    Type: Application
    Filed: September 18, 2003
    Publication date: June 17, 2004
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: Zhuyin Julie Li, Shujaath Mehdi
  • Patent number: 6172044
    Abstract: This invention relates to acylated enol derivatives of &agr;-ketoesters and &agr;-ketoamides. The compounds of this invention are either prodrugs of known elastase inhibitors or are elastase inhibitors in their own right and are useful in the treatment of various inflammatory diseases, including cystic fibrosis and emphysema.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: January 9, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Norton P. Peet, Joseph P. Burkhart, Shujaath Mehdi
  • Patent number: 5972897
    Abstract: This invention relates to acylated enol derivatives of known elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases, including cystic fibrosis and emphysema or as prodrugs of compounds which are useful in the treatment of said diseases.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: October 26, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Norton P. Peet, Joseph P. Burkhart, Shujaath Mehdi
  • Patent number: 5948886
    Abstract: This invention relates to acylated enol derivatives of .alpha.-ketoesters and .alpha.-ketoamides. The compounds of this invention are either prodrugs of known elastase inhibitors or are elastase inhibitors in their own right and are useful in the treatment of various inflammatory diseases, including cystic fibrosis and emphysema.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: September 7, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Norton P. Peet, Joseph P. Burkhart, Shujaath Mehdi
  • Patent number: 5880119
    Abstract: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 9, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • Patent number: 5750521
    Abstract: The present invention relates to certain mercaptoacetylamide disulfide derivatives of Formula (I) ##STR1## useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: May 12, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Shujaath Mehdi, Alan M. Warshawsky, John F. French, John H. Kehne
  • Patent number: 5736520
    Abstract: This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by H, an aldehyde, a substituted carbonyl or a substituted malonyl moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: April 7, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Philippe Bey, Michael R. Angelastro, Shujaath Mehdi
  • Patent number: 5731306
    Abstract: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: March 24, 1998
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • Patent number: 5698523
    Abstract: This invention relates to acylated enol derivatives of known elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases, including cystic fibrosis and emphysema or as prodrugs of compounds which are useful in the treatment of said diseases.
    Type: Grant
    Filed: June 25, 1996
    Date of Patent: December 16, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Norton P. Peet, Joseph P. Burkhart, Shujaath Mehdi
  • Patent number: 5691368
    Abstract: This invention relates to oxazolidine inhibitors of calpain and/or cathepsin B and to compositions containing them. As inhibitors of calpain and/or cathepsin B, the compounds are useful in the treatment of patients afflicted with acute or chronic neurodegenerative disorders.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: November 25, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Norton P. Peet, Shujaath Mehdi, Matthew D. Linnik, Michael R. Angelastro, Hwa-Ok Kim
  • Patent number: 5661167
    Abstract: The present invention relates to compounds of formula 1, ##STR1## including all of its stereoisomers, compositions, and processes for preparation of the same. The compounds of the present invention are also useful in their pharmacological activities as they directly act as inhibitors of prolyl endopeptidase and thereby provide a methods for memory enhancement, preventing or slowing the affects of amnesia or memory deficits.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: August 26, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Norton P. Peet, Shujaath Mehdi, Joseph P. Burkhart
  • Patent number: 5629309
    Abstract: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: May 13, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne