Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.

Abstract: A catheter includes an elongated shaft extending in a longitudinal direction and possessing an outer surface, the shaft possessing a distal end, a proximal end and a proximal portion which includes the proximal end, a transverse direction being perpendicular to the longitudinal direction, the elongated shaft being an elongated tubular body having a lumen formed therein, and a tubular hub fixed by insert molding to the outer surface of the shaft along the proximal portion of the shaft. The hub possesses a residual stress at one predetermined location of the hub that exceeds the residual stress of the hub at each of: (i) a first position distal to the one predetermined location, (ii) a second position proximal to the one predetermined location, and (iii) a third position being at the one predetermined location in the longitudinal direction and spaced apart from the one predetermined location in the transverse direction.

Abstract: A catheter includes an elongated shaft extending in a longitudinal direction and possessing an outer surface, the shaft possessing a distal end, a proximal end and a proximal portion which includes the proximal end, a transverse direction being perpendicular to the longitudinal direction, the elongated shaft being an elongated tubular body having a lumen formed therein, and a tubular hub fixed by insert molding to the outer surface of the shaft along the proximal portion of the shaft. The hub possesses a residual stress at one predetermined location of the hub that exceeds the residual stress of the hub at each of: (i) a first position distal to the one predetermined location, (ii) a second position proximal to the one predetermined location, and (iii) a third position being at the one predetermined location in the longitudinal direction and spaced apart from the one predetermined location in the transverse direction.

Abstract: A catheter manufacturing method includes positioning a shaft in a cavity of a mold. The shaft is an elongated tubular body configured to be inserted into a living body. The mold includes a first mold die and a second mold die that contact one another to define a closed space which is the cavity. The method includes injecting a molding material into the cavity from a gate at a position between the proximal end and the distal end of the shaft in the axial direction. The injecting position is offset from the center of the shaft in the transverse direction. The method includes molding a hub onto the shaft by solidifying the injected molding material in the cavity onto the outer surface of the shaft.

Abstract: A catheter manufacturing method includes positioning a shaft in a cavity of a mold. The shaft is an elongated tubular body configured to be inserted into a living body. The mold includes a first mold die and a second mold die that contact one another to define a closed space which is the cavity. The method includes injecting a molding material into the cavity from a gate at a position between the proximal end and the distal end of the shaft in the axial direction. The injecting position is offset from the center of the shaft in the transverse direction. The method includes molding a hub onto the shaft by solidifying the injected molding material in the cavity onto the outer surface of the shaft.