Patents by Inventor Shun Shimizu

Shun Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240158785
    Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.
    Type: Application
    Filed: January 12, 2024
    Publication date: May 16, 2024
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shigero Tamba, Shun Shimizu, Kanako Tatsumi, Shojiro Kadono, Hiroki Kawauchi, Kazuhiro Ohara, Masayuki Matsushita, Takashi Emura, Masaki Kamimura
  • Publication number: 20240158482
    Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.
    Type: Application
    Filed: December 20, 2023
    Publication date: May 16, 2024
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Miho Funaki, Naoka Hironiwa, Atsuhiko Maeda, Junichi Nezu, Yoshinao Ruike, Takeshi Baba, Shun Shimizu
  • Publication number: 20240140477
    Abstract: A processing system including a processor is configured to perform recognition-related processing related to recognition of a target movable body for a host movable body. The processor is configured to execute acquiring a recognition rate of recognizing a target movable body for each of a plurality of recognition models, and fusing recognition data by each of the plurality of recognition models according to a fusion rate based on a recognition score.
    Type: Application
    Filed: January 9, 2024
    Publication date: May 2, 2024
    Inventor: SHUN SHIMIZU
  • Patent number: 11952422
    Abstract: Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: April 9, 2024
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shun Shimizu, Shu Wen Samantha Ho, Naoka Hironiwa, Mika Sakurai, Taro Miyazaki, Tomoyuki Igawa
  • Publication number: 20240083429
    Abstract: By a traveling position determination device, a traveling position determination method, a non-transitory computer-readable storage medium storing a traveling position determination program, or by a non-transitory computer-readable storage medium storing a map data structure including a traveling position of a vehicle capable of performing automated driving, an offset of the traveling position in a lateral direction of the vehicle with respect to a reference position is determined.
    Type: Application
    Filed: November 22, 2023
    Publication date: March 14, 2024
    Inventors: SHUN SHIMIZU, MINORU OKADA, HIROSHI INOU
  • Patent number: 11912989
    Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: February 27, 2024
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shigero Tamba, Shun Shimizu, Kanako Tatsumi, Shojiro Kadono, Hiroki Kawauchi, Kazuhiro Ohara, Masayuki Matsushita, Takashi Emura, Masaki Kamimura
  • Publication number: 20240059774
    Abstract: The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.
    Type: Application
    Filed: September 19, 2023
    Publication date: February 22, 2024
    Inventors: Hitoshi KATADA, Kanako TATSUMI, Yutaka MATSUDA, Shun SHIMIZU, Masaki KAMIMURA, Yasunori KOMORI, Yuji HORI, Tomoyuki IGAWA, Hiroki KAWAUCHI, Hiroki HAYASHI, Hiroaki SUSUMU
  • Patent number: 11891434
    Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: February 6, 2024
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Miho Funaki, Naoka Hironiwa, Atsuhiko Maeda, Junichi Nezu, Yoshinao Ruike, Takeshi Baba, Shun Shimizu
  • Publication number: 20240002510
    Abstract: The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.
    Type: Application
    Filed: June 24, 2022
    Publication date: January 4, 2024
    Inventors: Hitoshi KATADA, Kanako TATSUMI, Yutaka MATSUDA, Shun SHIMIZU, Masaki KAMIMURA, Yasunori KOMORI, Yuji HORI, Tomoyuki IGAWA, Hiroki KAWAUCHI, Hiroki HAYASHI, Hiroaki SUSUMU, Shimon SAKAGUCHI
  • Publication number: 20230322898
    Abstract: The present invention provides a pharmaceutical composition comprising cells expressing a chimeric receptor, for use in combination with administration of an antigen-binding molecule, wherein the chimeric receptor comprises an extracellular domain, the extracellular domain comprises an extracellular domain of an immunoreceptor, an extracellular domain variant of an immunoreceptor, or a portion thereof, and the antigen-binding molecule is a multispecific antigen-binding molecule having a target antigen recognition site and an immunoreceptor recognition site which recognizes the immunoreceptor.
    Type: Application
    Filed: July 30, 2021
    Publication date: October 12, 2023
    Applicants: Chugai Seiyaku Kabushiki Kaisha, Yamaguchi University
    Inventors: Tomoyuki Igawa, Mika Sakurai, Takashi Suzuki, Kanako Tatsumi, Shun Shimizu, Koji Tamada, Yukimi Sakoda
  • Publication number: 20230279099
    Abstract: The present inventors discovered that problems of existing antibody pharmaceuticals can be solved by producing antigen-binding molecules that contain an antigen-binding domain whose antigen-binding activity varies depending on the concentration of a target tissue-specific compound. Use of antigen-binding molecules of the present invention enables various diseases that originate from a target tissue to be treated in a manner specific to the target tissue.
    Type: Application
    Filed: April 25, 2023
    Publication date: September 7, 2023
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shigero Tamba, Kanako Tatsumi, Shun Shimizu, Shojiro Kadono
  • Patent number: 11673947
    Abstract: The present inventors discovered that problems of existing antibody pharmaceuticals can be solved by producing antigen-binding molecules that contain an antigen-binding domain whose antigen-binding activity varies depending on the concentration of a target tissue-specific compound. Use of antigen-binding molecules of the present invention enables various diseases that originate from a target tissue to be treated in a manner specific to the target tissue.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: June 13, 2023
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shigero Tamba, Kanako Tatsumi, Shun Shimizu, Shojiro Kadono
  • Publication number: 20230066475
    Abstract: A semiconductor storage device includes: a first stack having a first insulation film and a first conductive film alternately stacked in a first direction; a plurality of first column portions respectively including a first semiconductor portion extending in the first stack in the first direction and a charge trapping film provided on an outer circumferential surface of the first semiconductor portion; and a first isolation portion penetrating through an upper-layer portion of the first stack in the first direction, extending in a second direction that crosses the first direction, including a second insulation film and a third insulation film arranged via the second insulation film, and configured to electrically isolate the first conductive film included in the upper-layer portion of the first stack in a third direction that crosses the first and second directions.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 2, 2023
    Applicant: Kioxia Corporation
    Inventors: Shun SHIMIZU, Takashi ISHIDA
  • Publication number: 20230058982
    Abstract: The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region and methods of producing and using the polypeptides.
    Type: Application
    Filed: December 27, 2019
    Publication date: February 23, 2023
    Inventors: Hitoshi KATADA, Kanako TATSUMI, Kanako ATSUMI, Shun SHIMIZU, Masaki KAMIMURA, Yasunori KOMORII, Yuji HORI, Tomoyuki IGAWA, Hiroki KAWAUCHI, Hiroaki SUSUMU
  • Publication number: 20230020377
    Abstract: The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.
    Type: Application
    Filed: June 24, 2022
    Publication date: January 19, 2023
    Inventors: Hitoshi KATADA, Kanako Tatsumi, Yutaka Matsuda, Shun Shimizu, Masaki Kamimura, Yasunori Komori, Yuji Hori, Tomoyuki Igawa, Hiroki Kawauchi, Hiroki Hayashi, Hiroaki Susumu, Shimon Sakaguchi
  • Publication number: 20220187308
    Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 16, 2022
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki IGAWA, Shinya ISHII, Miho FUNAKI, Naoka HIRONIWA, Shun SHIMIZU
  • Patent number: 11299203
    Abstract: In a cruise assist system, a turning angle controller executes at least one of an automatic cruise control task that automatically controls a turning angle of the vehicle, and an assist control task that controls the turning angle of the vehicle in accordance with an occupant's operation of the steering wheel. A holding determiner includes an input detector detecting an occupant's physical input to a steering shaft via a steering wheel based on at least one of a first type physical quantity and second type physical quantities. Each of the first and second physical quantities depends on rotational movement of the steering shaft. The first type physical quantity contains the occupant's physical input, and a disturbance input, which is different therefrom, to the steering shaft. The second type physical quantities have a physical relationship therebetween, which is changed depending on the occupant's physical input.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: April 12, 2022
    Assignee: DENSO CORPORATION
    Inventors: Shun Shimizu, Yosuke Hirate, Daiji Watanabe, Toshiya Kabayama, Hisaya Akatsuka
  • Patent number: 11243210
    Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: February 8, 2022
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Miho Funaki, Naoka Hironiwa, Shun Shimizu
  • Patent number: 11181920
    Abstract: A travel assistance method that is performed by a computer including at least one processor is provided. The travel assistance method assists travel of a subject vehicle and includes: setting a start point and an end point of a route where the subject vehicle travels along a curve; assuming a triangle including the start point and the end point; setting a control point on each of two sides of the triangle to assume a quadrangle; calculating a route line accommodated in the quadrangle; and assisting the subject vehicle in traveling along the curve.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 23, 2021
    Assignee: DENSO CORPORATION
    Inventor: Shun Shimizu
  • Publication number: 20210324099
    Abstract: An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same. Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided. The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.
    Type: Application
    Filed: August 9, 2019
    Publication date: October 21, 2021
    Inventors: Tomoyuki IGAWA, Mika SAKURAI, Shun SHIMIZU, Yuji HORI, Naoka HIRONIWA, Nasa SAVORY, Yoshinori NARITA, Takayuki KAMIKAWA, Taro MIYAZAKI, Shojiro KADONO, Masami HASEGAWA, Kanako TATSUMI, Akira HAYASAKA, Takeaki KAWAI, Futa MIMOTO, Hiroki KAWAUCHI, Masaki KAMIMURA