Patents by Inventor Shuvo Roy

Shuvo Roy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10730016
    Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: August 4, 2020
    Assignees: The Regents of the University of Michigan, The Cleveland Clinic Foundation
    Inventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
  • Patent number: 10695480
    Abstract: Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: June 30, 2020
    Assignee: The Regents of the University of California
    Inventors: Shuvo Roy, Torin Yeager, Emily Abada, Ajay S. Dharia
  • Publication number: 20200114058
    Abstract: Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.
    Type: Application
    Filed: June 20, 2018
    Publication date: April 16, 2020
    Inventors: Shuvo Roy, William Fissell, Nathan Wright, Mark Goodin, Steven G. Goebel, Amanda Buck, Joey Groszek
  • Patent number: 10463293
    Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: November 5, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michel Maharbiz, Vivek Subramanian, Ana Claudia Arias, Sarah Swisher, Amy Liao, Monica Lin, Felippe Pavinatto, Yasser Khan, Daniel Cohen, Elisabeth Leeflang, Shuvo Roy, Michael Harrison, David Young
  • Publication number: 20190269841
    Abstract: The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.
    Type: Application
    Filed: March 14, 2019
    Publication date: September 5, 2019
    Inventors: Rishi Kant, Shuvo Roy, Benjamin Chui, Kenneth G. Goldman
  • Publication number: 20190216998
    Abstract: (57) Abstract: Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.
    Type: Application
    Filed: March 7, 2017
    Publication date: July 18, 2019
    Applicant: The Regents of the University of California
    Inventors: Shuvo ROY, Rishi KANT, Andrew POSSELT, Shang SONG, Willieford MOSES, Charles BLAHA
  • Publication number: 20190134568
    Abstract: Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 9, 2019
    Inventor: Shuvo Roy
  • Patent number: 10265452
    Abstract: The present technology provides microfabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: April 23, 2019
    Assignee: The Regents of the University of California
    Inventors: Rishi Kant, Shuvo Roy, Benjamin Chui, Kenneth G. Goldman
  • Publication number: 20180141003
    Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.
    Type: Application
    Filed: October 27, 2017
    Publication date: May 24, 2018
    Inventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
  • Publication number: 20170361007
    Abstract: Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.
    Type: Application
    Filed: November 18, 2015
    Publication date: December 21, 2017
    Inventors: Shuvo Roy, Torin Yeager, Emily Abada, Ajay S. Dharia
  • Patent number: 9802158
    Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: October 31, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE CLEVELAND CLINIC FOUNDATION
    Inventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
  • Patent number: 9737653
    Abstract: A system and method provide improved ultrafiltration of charged/uncharged solutes in a fluid, especially a body fluid. The improvement is achieved through imposed electric field and/or surface charge patterning to a permeable membrane. In many of the embodiments, at least one selected material is used as an additive on a permeate side of the permeable membrane to reduce the sieving coefficient of the membrane with regard to a solute present in the fluid.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: August 22, 2017
    Inventors: Albert Terrence Conlisk, Jr., Subhra Datta, William H. Fissell, Shuvo Roy
  • Publication number: 20170156658
    Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 8, 2017
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michel Maharbiz, Vivek Subramanian, Ana Claudia Arias, Sarah Swisher, Amy Liao, Monica Lin, Felippe Pavinatto, Yasser Khan, Daniel Cohen, Elisabeth Leeflang, Shuvo Roy, Michael Harrison, David Young
  • Publication number: 20160332119
    Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 17, 2016
    Inventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
  • Patent number: 9403126
    Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: August 2, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE CLEVELAND CLINIC FOUNDATION
    Inventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
  • Publication number: 20150090661
    Abstract: The present technology provides microfabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.
    Type: Application
    Filed: May 16, 2013
    Publication date: April 2, 2015
    Inventors: Rishi Kant, Shuvo Roy, Benjamin Chui, Kenneth G. Goldman
  • Publication number: 20150077208
    Abstract: A parallel-trace spiral coil comprising a plurality of electrically-isolated, parallel connected metal traces with high Q factor for use in bio-medical implants.
    Type: Application
    Filed: September 16, 2013
    Publication date: March 19, 2015
    Inventors: Ken Goldman, Hao Jiang, Shuvo Roy
  • Publication number: 20130197420
    Abstract: One aspect of the present invention relates to a silicon nanoporous membrane for oxygenating blood. The nanoporous membrane includes a first major surface, a second major surface, and a plurality of pores extending between the first and second major surfaces. The first major surface is for contacting a gas. The second major surface is for contacting blood and is oppositely disposed from said first major surface. The first and second major surfaces define a membrane thickness. Each of the pores is defined by a length, a width, and a height. Each of the pores is separated by a uniform interpore distance.
    Type: Application
    Filed: January 19, 2011
    Publication date: August 1, 2013
    Inventors: William H. Fissell, IV, Harihara Baskaran, Shuvo Roy, Ken Goldman
  • Publication number: 20120310136
    Abstract: A system and method provide improved ultrafiltration of charged/uncharged solutes in a fluid, especially a body fluid. The improvement is achieved through imposed electric field and/or surface charge patterning to a permeable membrane. In many of the embodiments, at least one selected material is used as an additive on a permeate side of the permeable membrane to reduce the sieving coefficient of the membrane with regard to a solute present in the fluid.
    Type: Application
    Filed: August 1, 2011
    Publication date: December 6, 2012
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Albert Terrence Conlisk, JR., Subhra Datta, William H. Fissell, Shuvo Roy
  • Patent number: 7878208
    Abstract: Methods and systems are provided for determining a characteristic of an in vivo sensor. A transmit field, operative to induce a response signal in an associated in vivo sensor, is generated at a transmitting component having an associated orientation. The response signal is received at a receiving component, having an associated orientation. The coupling between the transmitting component and the receiving component is measured. The associated orientation of at least one of the transmitting component and the receiving component is rotated as to reduce the measured coupling.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: February 1, 2011
    Assignee: The Cleveland Clinic Foundation
    Inventors: James R. Talman, Shuvo Roy, Brian L. Sauer, Aaron J. Fleischman