Patents by Inventor Shyam Biswal

Shyam Biswal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150080462
    Abstract: The present invention features methods for treating or preventing conditions, diseases, or disorders related to oxidative stress. In one embodiment, the method increases Nrf2 biological activity or expression. In particular, the invention provides for the treatment or prevention of diseases relating to oxidative stress including emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia and neurodegenerative disorders, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia, cognitive deficits and neurodegenerative disorders.
    Type: Application
    Filed: August 4, 2014
    Publication date: March 19, 2015
    Inventors: Shyam Biswal, Sylvain Dore, Rajesh Kumar Thimmulappa, Tirumalai Rangasamy, Yoshihito Sakata, Zahoor Ahmad Shah, Hean Zhuang, Anju Singh
  • Publication number: 20140088052
    Abstract: Compounds and methods for treating or preventing a disease, disorder or condition associated with an Nrf2-regulated pathway, including those associated with an autoimmune disease, comorbidity associated with diabetes, such as retinopathy and nephropathy, bone marrow transplant for leukemia and related cancers, bone marrow deficiencies, inborn errors of metabolism, and other immune disorders, oxidative stress, respiratory infection, ischemia, neurodegenerative disorders, radiation injury, neutropenia caused by chemotherapy, autoimmunity, and congenital neutropenic disorders, and for restoring a corticosteroid responsiveness, in a subject are provided.
    Type: Application
    Filed: February 27, 2012
    Publication date: March 27, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shyam Biswal, Rajesh Thimmulappa, Sarvesh Kumar, Sanjay V. Malhotra, Vineet Kumar, Kim Jung-Hyun
  • Publication number: 20130309323
    Abstract: The invention generally features compositions and methods useful for the treatment and diagnosis of a neoplasia in a subject. In particular, the invention provides therapeutic compositions that decrease the expression of an Nfr2 nucleic acid molecule or polypeptide for the treatment of a neoplasia, such as a chemoresistant neoplasia, in a subject.
    Type: Application
    Filed: June 14, 2012
    Publication date: November 21, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shyam Biswal, Anju Singh
  • Publication number: 20130039928
    Abstract: The present invention features methods for reversing corticosteroid resistance, as well as for the treatment of respiratory infections, particularly those associated with chronic obstructive pulmonary disease. In one embodiment, the method increases Nrf2 biological activity or expression.
    Type: Application
    Filed: January 28, 2011
    Publication date: February 14, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shyam Biswal, Rajesh K. Thimmulappa
  • Patent number: 8216777
    Abstract: The invention generally features compositions and methods useful for the treatment and diagnosis of a neoplasia in a subject. In particular, the invention provides therapeutic compositions that decrease the expression of an Nfr2 nucleic acid molecule or polypeptide for the treatment of a neoplasia, such as a chemoresistant neoplasia, in a subject.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: July 10, 2012
    Assignee: The Johns Hopkins University
    Inventors: Shyam Biswal, Anju Singh
  • Publication number: 20120029071
    Abstract: The invention provides compositions and methods featuring Nrf2 activators for treating or preventing radiation-associated tissue damage.
    Type: Application
    Filed: November 23, 2009
    Publication date: February 2, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shyam Biswal, Rajesh K. Thimmulappa
  • Publication number: 20110250300
    Abstract: The present invention features methods for treating or preventing conditions, diseases, or disorders related to oxidative stress. In one embodiment, the method increases Nrf2 biological activity or expression. In particular, the invention provides for the treatment or prevention of diseases relating to oxidative stress including emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia and neurodegenerative disorders, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia, cognitive deficits and neurodegenerative disorders.
    Type: Application
    Filed: May 14, 2010
    Publication date: October 13, 2011
    Applicant: The Johns Hopkins University
    Inventors: Shyam Biswal, Rajesh K. Thimmulappa
  • Publication number: 20100255117
    Abstract: The instant invention provides methods and compositions for the treatment of cancer.
    Type: Application
    Filed: April 6, 2008
    Publication date: October 7, 2010
    Applicant: The Johns Hopkins University
    Inventors: Shyam Biswal, Anju Singh, Deepti Malhotra
  • Publication number: 20100047368
    Abstract: The invention generally features compositions and methods useful for the treatment and diagnosis of a neoplasia in a subject. In particular, the invention provides therapeutic compositions that decrease the expression of an Nfr2 nucleic acid molecule or polypeptide for the treatment of a neoplasia, such as a chemoresistant neoplasia, in a subject.
    Type: Application
    Filed: May 26, 2006
    Publication date: February 25, 2010
    Inventors: Shyam Biswal, Anju Singh