Patents by Inventor Shyoichiro Miyahara

Shyoichiro Miyahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing of human tissue type plasminogen activator
    Patent number: 5151359
    Abstract: A method for the production of human tissue type plasminogen activator (tPa) using cells is disclosed. The method includes a supplementation of a p-aminomethyl benzoic acid derivative to a cell culture medium or a tPA producing medium and further an increase of osmotic pressure in the medium to 350 milliosmoles or more/liter. The invention provides a method for producing single-chain tPA in a high concentration and with a relatively small amount of double-chain tPA in the medium.
    Type: Grant
    Filed: May 5, 1989
    Date of Patent: September 29, 1992
    Assignee: Mitsui Toatsu Chemicals Incorporated
    Inventors: Shyoichiro Miyahara, Maki Suzuki, Atsunori Shindo, Nobumi Kusuhara, Nobuyoshi Makiguchi
  • Method for production of cystine from cysteine
    Patent number: 4769491
    Abstract: From the aqueous solution containing cysteine obtained by the enzymatic method or fermentative method, cystine is produced in a high yield by oxidizing the cysteine in the presence of dimethyl sulfoxide.
    Type: Grant
    Filed: May 12, 1987
    Date of Patent: September 6, 1988
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Shyoichiro Miyahara, Toshiaki Kamiguchi, Tooru Miyahara, Hashimukai Tadashi, Nitta Kazunari
  • Method of separating monohydrate of L-cysteine hydrochloride
    Patent number: 4733010
    Abstract: Hydrochloric acid is added to a solution containing L-cysteine, L-cystine, L-serine and an inorganic salt until it contains at least 15% by weight of hydrochloric acid. The solution is held at a temperature of at least 20.degree. C. so that the L-cystine and the inorganic salt may form a solid, and the solid is removed from the solution. The solution is cooled to a temperature not exceeding 10.degree. C., so that crystallization may take place to form the monohydrate of L-cysteine hydrochloride. The monohydrate is separated from the L-serine in the solution.
    Type: Grant
    Filed: June 9, 1987
    Date of Patent: March 22, 1988
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Shyoichiro Miyahara, Toshiaki Kamiguchi, Tadashi Hashimukai, Kazunari Nitta