Patents by Inventor Sihong Chen
Sihong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
SEMANTIC SEGMENTATION METHOD AND APPARATUS FOR THREE-DIMENSIONAL IMAGE, TERMINAL, AND STORAGE MEDIUM
Publication number: 20210049397Abstract: A semantic segmentation method and apparatus for a three-dimensional image, and a storage medium are provided. The method includes: obtaining a three-dimensional image; slicing the three-dimensional image according to three directional planes, to obtain two-dimensional slice images of an x axis, two-dimensional slice images of a y axis, and two-dimensional slice images of a z axis; invoking a first segmentation model, a second segmentation model, and a third segmentation model to respectively perform semantic segmentation on the two-dimensional slice images of the x axis, the y axis, and the z axis, to obtain distribution probability maps of a target object on the three directional planes; and obtaining a three-dimensional distribution binary image of the target object by invoking an adaptive fusion model to perform three-dimensional fusion on the three distribution probability maps respectively corresponding to an x-axis directional plane, a y-axis directional plane, and a z-axis directional plane.Type: ApplicationFiled: October 20, 2020Publication date: February 18, 2021Inventor: Sihong CHEN -
Patent number: 10921191Abstract: An atomic sensing method, the method including providing a polarization converter; emitting a linearly polarized polychromatic laser beam to the polarization converter; converting, by the polarization converter, the linearly polarized polychromatic laser beam into a circularly-polarized laser beam and a linearly-polarized laser beam; combining the circularly-polarized laser beam and the linearly-polarized laser beam thereby yielding a multi-polarization polychromatic laser beam; transmitting the multi-polarization polychromatic laser beam to an atomic vapor cell comprising alkali metal atoms, polarizing the multi-polarization polychromatic laser beam into two laser beams, and detecting the two laser beams by two photodetectors, respectively.Type: GrantFiled: February 23, 2020Date of Patent: February 16, 2021Assignee: WUHAN INSTITUTE OF PHYSICS AND MATHEMATICS, CHINESE ACADEMY OF SCIENCEInventors: Yi Zhang, Sihong Gu, Yuan Tian, Jiehua Chen
-
Publication number: 20210019890Abstract: An image segmentation method is provided for a computer device. The method includes obtaining a plurality of sample images, calling an initial model to input the plurality of sample images into the initial model and to train the initial model based on the plurality of sample images to obtain an image segmentation model and, based on the initial model, determining a number of image segmentation modules according to a number of types of pixels of the plurality of sample images. Different image segmentation modules are used for segmenting different regions of an image. The method also includes calling the image segmentation model in response to obtaining a first image to be segmented, and segmenting the first image by using the image segmentation model based on a plurality of image segmentation modules, to output a second image. Computer device and non-transitory computer-readable storage medium counterparts are also contemplated.Type: ApplicationFiled: September 30, 2020Publication date: January 21, 2021Inventor: Sihong CHEN
-
Publication number: 20200399633Abstract: The present disclosure describes oligonucleotide-tethered nucleotides, methods of making them, and methods of using them. The oligonucleotide-tethered nucleotides comprise, in some embodiments, a nucleotide linked to an oligonucleotide of from about 3 to about 100 nucleotides in length. These oligonucleotide-tethered nucleotides can be used to label a plurality of different types of nucleic acids in a plurality of different situations with a known oligonucleotide, which can serve as a barcode in some embodiments. The resulting oligonucleotide-labeled nucleic acids oligonucleotides can be used in a variety of nucleic acid sequencing methods.Type: ApplicationFiled: June 22, 2020Publication date: December 24, 2020Inventors: Arvydas LUBYS, Inga CIKOTIENE, Zana KAPUSTINA, Arturas BEREZNIAKOVAS, Justina MEDZIUNE, Simona ZEIMYTE, Mark ANDERSEN, Michael ALLEN, Sihong CHEN
-
Publication number: 20200385786Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof, such as modified Taq polymerases, are provided that allow for improved nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having improved thermostability, accuracy, processivity and/or read length as compared to a referenceTaq polymerase. In some aspects, the disclosure relates to modified polymerases or biologically active fragments thereof, useful for amplification methods, and in practically illustrative embodiments, emulsion PCR.Type: ApplicationFiled: August 14, 2020Publication date: December 10, 2020Inventors: Daniel MAZUR, Eileen TOZER, Sihong CHEN, Peter VANDER HORN, Tommie LINCECUM
-
Publication number: 20200271523Abstract: An atomic sensing method, the method including providing a polarization converter; emitting a linearly polarized polychromatic laser beam to the polarization converter; converting, by the polarization converter, the linearly polarized polychromatic laser beam into a circularly-polarized laser beam and a linearly-polarized laser beam; combining the circularly-polarized laser beam and the linearly-polarized laser beam thereby yielding a multi-polarization polychromatic laser beam; transmitting the multi-polarization polychromatic laser beam to an atomic vapor cell comprising alkali metal atoms, polarizing the multi-polarization polychromatic laser beam into two laser beams, and detecting the two laser beams by two photodetectors, respectively.Type: ApplicationFiled: February 23, 2020Publication date: August 27, 2020Inventors: Yi ZHANG, Sihong GU, Yuan TIAN, Jiehua CHEN
-
Patent number: 10745747Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof, such as modified Taq polymerases, are provided that allow for improved nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having improved thermostability, accuracy, processivity and/or read length as compared to a referenceTaq polymerase. In some aspects, the disclosure relates to modified polymerases or biologically active fragments thereof, useful for amplification methods, and in practically illustrative embodiments, emulsion PCR.Type: GrantFiled: April 24, 2018Date of Patent: August 18, 2020Assignee: Life Technologies CorporationInventors: Daniel Mazur, Eileen Tozer, Sihong Chen, Peter Vander Horn, Tommie Lincecum
-
Publication number: 20190270974Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, recombinant polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides recombinant polymerases that yield lower systematic error rates and/or improved accuracy, when used in sequencing by synthesis reactions as compared to a control polymerase. In one aspect, the disclosure relates to recombinant polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In another aspect, the recombinant polymerases are useful for the amplification of nucleic acid templates during PCR, emPCR, isothermal amplification, recombinase polymerase amplification, rolling circle amplification, strand displacement amplification and proximity ligation amplification.Type: ApplicationFiled: May 17, 2019Publication date: September 5, 2019Inventors: Daniel MAZUR, Peter VANDER HORN, Eileen TOZER, Sihong CHEN, Guobin LUO, Joshua SHIRLEY, Kevin HEINEMANN
-
Patent number: 10344268Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, recombinant polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides recombinant polymerases that yield lower systematic error rates and/or improved accuracy, when used in sequencing by synthesis reactions as compared to a control polymerase. In one aspect, the disclosure relates to recombinant polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In another aspect, the recombinant polymerases are useful for the amplification of nucleic acid templates during PCR, emPCR, isothermal amplification, recombinase polymerase amplification, rolling circle amplification, strand displacement amplification and proximity ligation amplification.Type: GrantFiled: September 27, 2016Date of Patent: July 9, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Daniel Mazur, Peter Vander Horn, Eileen Tozer, Sihong Chen, Guobin Luo, Joshua Shirley, Kevin Heinemann
-
Publication number: 20180312904Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof, such as modified Taq polymerases, are provided that allow for improved nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having improved thermostability, accuracy, processivity and/or read length as compared to a referenceTaq polymerase. In some aspects, the disclosure relates to modified polymerases or biologically active fragments thereof, useful for amplification methods, and in practically illustrative embodiments, emulsion PCR.Type: ApplicationFiled: April 24, 2018Publication date: November 1, 2018Inventors: Daniel Mazur, Eileen Tozer, Sihong Chen, Peter Vander Horn, Tommie Lincecum
-
Patent number: 9976178Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof, such as modified Taq polymerases, are provided that allow for improved nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having improved thermostability, accuracy, processivity and/or read length as compared to a reference Taq polymerase. In some aspects, the disclosure relates to modified polymerases or biologically active fragments thereof, useful for amplification methods, and in practically illustrative embodiments, emulsion PCR.Type: GrantFiled: December 16, 2015Date of Patent: May 22, 2018Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Daniel Mazur, Eileen Tozer, Sihong Chen, Peter Vander Horn, Tommie Lincecum
-
Publication number: 20170096648Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, recombinant polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides recombinant polymerases that yield lower systematic error rates and/or improved accuracy, when used in sequencing by synthesis reactions as compared to a control polymerase. In one aspect, the disclosure relates to recombinant polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In another aspect, the recombinant polymerases are useful for the amplification of nucleic acid templates during PCR, emPCR, isothermal amplification, recombinase polymerase amplification, rolling circle amplification, strand displacement amplification and proximity ligation amplification.Type: ApplicationFiled: September 27, 2016Publication date: April 6, 2017Inventors: DANIEL MAZUR, Peter VANDER HORN, Eileen TOZER, Sihong CHEN, Guobin LUO, Joshua SHIRLEY, Kevin HEINEMANN
-
Publication number: 20160177373Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof, such as modified Taq polymerases, are provided that allow for improved nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having improved thermostability, accuracy, processivity and/or read length as compared to a reference Taq polymerase. In some aspects, the disclosure relates to modified polymerases or biologically active fragments thereof, useful for amplification methods, and in practically illustrative embodiments, emulsion PCR.Type: ApplicationFiled: December 16, 2015Publication date: June 23, 2016Inventors: Daniel Mazur, Eileen Tozer, Sihong Chen, Peter Vander Horn, Tommie Lincecum