Patents by Inventor Silvia Filippini

Silvia Filippini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing doxorubicin
    Patent number: 6210930
    Abstract: The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: April 3, 2001
    Assignee: Pharmacia & Upjohn, S.P.A.
    Inventors: Silvia Filippini, Natalia Lomovskaya, Leonid Fonstein, Anna Luisa Colombo, C. Richard Hutchinson, Sharee L. Otten, Umberto Breme
  • Process for preparing daunorubicin and doxorubicin
    Patent number: 5989869
    Abstract: The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism involved in the glycosylation of daunorubicin to acid-sensitive, baumycin-like compounds is inactivated.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: November 23, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Silvia Filippini, Natalia Lomovskaya, Leonid Fonstein, Anna Luisa Colombo, C. Richard Hutchinson
  • Process for preparing doxorubicin
    Patent number: 5955319
    Abstract: The present invention concerns a process for improving doxorubicin production by means of a recombinant Streptomyces peucetius strain bearing a mutation in the gene dnrU coding for a protein involved in the metabolism of daunorubicin.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: September 21, 1999
    Assignee: Pharmacia & Upjohn, S.p.A.
    Inventors: Silvia Filippini, Umberto Breme, Anna Luisa Colombo, Natasha Lomovskaya, Leonid Fonstein, Sharee Otten, Charles R. Hutchinson
  • Process for preparing daunorubicin
    Patent number: 5652125
    Abstract: The ability to improve the conversion of .epsilon.-rhodomycinone to daunorubicin can be conferred on a bacterial host transformed with a recombinant vector comprising a DNA coding for an appropriate protein useful for that conversion. Furthermore, the bacterial host may have a mutation that blocks the function of a gene of daunorubicin metabolism.
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: July 29, 1997
    Assignee: Pharmacia S.p.A.
    Inventors: Claudio Scotti, Charles Richard Hutchinson, Anna Luisa Colombo, Silvia Filippini