Patents by Inventor Silvio Aime

Silvio Aime has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS COMPRISING GD-COMPLEXES AND POLYARYLENE ADDITIVES
    Publication number: 20220062444
    Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).
    Type: Application
    Filed: December 17, 2019
    Publication date: March 3, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Giuseppe FERRAUTO, Eliana GIANOLIO, Luciano LATTUADA, Alessandro MAIOCCHI
  • RATIOMETRIC PULSED CEST IMAGING
    Publication number: 20210263122
    Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 26, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
  • Contrast agents
    Patent number: 11021451
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: June 1, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • Contrast agents
    Patent number: 11007283
    Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: May 18, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • RATIOMETRIC PULSED CEST IMAGING
    Publication number: 20200379070
    Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
    Type: Application
    Filed: December 22, 2016
    Publication date: December 3, 2020
    Applicant: Bracco Imaging S.p.A.
    Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
  • CONTRAST AGENTS
    Publication number: 20200325108
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 15, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
  • Contrast agents
    Patent number: 10781188
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 22, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • Process for the preparation of hyperpolarized carboxylate compounds
    Patent number: 10695448
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular parahydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: June 30, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Tommaso Boi, Erika Cerutti, Francesca Reineri
  • Process For The Preparation Of Hyperpolarized Carboxylate Compounds
    Publication number: 20190298863
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular para-hydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.
    Type: Application
    Filed: June 17, 2019
    Publication date: October 3, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Tommaso BOI, Erika CERUTTI, Francesca REINERI
  • Process for the preparation of hyperpolarized carboxylate compounds
    Patent number: 10369236
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular parahydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: August 6, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Tommaso Boi, Erika Cerutti, Francesca Reineri
  • CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS
    Publication number: 20190209713
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
    Type: Application
    Filed: January 24, 2019
    Publication date: July 11, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Daniela DELLI CASTELLI, Franco FEDELI, Dario Livio LONGO, Enzo TERRENO, Fulvio UGGERI
  • CEST systems exhibiting a concentration independent responsiveness
    Patent number: 10328162
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: June 25, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Dario Livio Longo, Enzo Terreno, Fulvio Uggeri
  • CONTRAST AGENTS
    Publication number: 20190167819
    Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: April 5, 2017
    Publication date: June 6, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
  • CEST systems exhibiting a concentration independent responsiveness
    Patent number: 10232060
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: March 19, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Dario Livio Longo, Enzo Terreno, Fulvio Uggeri
  • CONTRAST AGENTS
    Publication number: 20180362476
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: December 12, 2016
    Publication date: December 20, 2018
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
  • Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
    Patent number: 9693828
    Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 4, 2017
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
  • Process for preparing hyperpolarized substrates and method for MRI
    Patent number: 9694090
    Abstract: The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: July 4, 2017
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Giovanni Battista Giovenzana, Fabio Tedoldi, Alessandro Maiocchi, Fulvio Uggeri, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Massimo Visigalli, Marco Crosetti, Luisa Poggi
  • Process for the preparation of hyperpolarized derivatives for use in MRI analysis
    Patent number: 9511154
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: December 6, 2016
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi
  • Process For The Preparation Of Hyperpolarized Carboxylate Compounds
    Publication number: 20160263256
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular parahydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.
    Type: Application
    Filed: October 27, 2014
    Publication date: September 15, 2016
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Tommaso BOI, Erika CERUTTI, Francesca REINERI
  • Integrin targeted synthetic ligands for diagnostic and therapeutic applications
    Patent number: 9409951
    Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: August 9, 2016
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio