Patents by Inventor Silviu Itescu

Silviu Itescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240091266
    Abstract: The present disclosure relates to opioid sparing compositions and use of the same for reducing opioid use. Such compositions and methods method may be used for reducing pain or reducing opioid use or increasing mobility in subjects using an opioid.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 21, 2024
    Inventors: Silviu ITESCU, Roger BROWN
  • Publication number: 20240041934
    Abstract: The present disclosure relates to methods for treating and/or preventing progressive heart failure in subjects with earlier stages of heart failure. Such method may be used for treating or preventing progressive heart failure in subjects with Class II heart failure according to the New York Heart Association (NYHA) classification scale.
    Type: Application
    Filed: December 15, 2021
    Publication date: February 8, 2024
    Inventors: Silviu ITESCU, Kenneth BOROW, Jack HAYES
  • Publication number: 20240024366
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: August 8, 2023
    Publication date: January 25, 2024
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • Publication number: 20230398154
    Abstract: The present disclosure relates to improved cellular compositions and potency assays for obtaining the same. Such compositions and assays may be suitable for use in treating various inflammatory disorders.
    Type: Application
    Filed: August 9, 2021
    Publication date: December 14, 2023
    Inventors: Silviu ITESCU, Paul SIMMONS
  • Publication number: 20230364149
    Abstract: The present disclosure relates to methods for treating or preventing heart failure in subjects with elevated left ventricular end systolic volume (LVESV). In particular, the present disclosure related to methods for treating or preventing heart failure in subjects with a LVESV of greater than 70 ml (>70 ml).
    Type: Application
    Filed: May 17, 2023
    Publication date: November 16, 2023
    Applicant: Mesoblast International Sàrl
    Inventors: Silviu Itescu, Lee Golden
  • Publication number: 20230346846
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: March 29, 2023
    Publication date: November 2, 2023
    Applicant: Mesoblast Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • Publication number: 20230293590
    Abstract: The present disclosure relates to cellular compositions that are modified to introduce an oncolytic virus. Such compositions may be used to treat cancer by delivering oncolytic virus to cancer cells.
    Type: Application
    Filed: August 10, 2021
    Publication date: September 21, 2023
    Inventors: Silviu ITESCU, Anthony SANDRASAGRA
  • Publication number: 20230293589
    Abstract: The present disclosure relates to method of treating or preventing an inflammatory lung disease in a subject in need thereof, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs).
    Type: Application
    Filed: March 4, 2021
    Publication date: September 21, 2023
    Inventor: Silviu ITESCU
  • Patent number: 11712452
    Abstract: The present disclosure relates to methods for treating or preventing heart failure in subjects with elevated left ventricular end systolic volume (LVESV). In particular, the present disclosure relates to methods for treating or preventing heart failure in subjects with a LVESV of greater than 70 ml (>70 ml).
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: August 1, 2023
    Assignee: MESOBLAST INTERNATIONAL SÀRL
    Inventors: Silviu Itescu, Lee Golden
  • Publication number: 20230172991
    Abstract: The present disclosure relates to method of treating or preventing inflammatory bowel disease (IBD) in a subject in need thereof, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs).
    Type: Application
    Filed: March 11, 2021
    Publication date: June 8, 2023
    Inventor: Silviu ITESCU
  • Publication number: 20230165904
    Abstract: The present disclosure relates to method of treating or preventing hyperinflammation in a subject in need thereof, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs).
    Type: Application
    Filed: April 1, 2021
    Publication date: June 1, 2023
    Inventor: Silviu ITESCU
  • Publication number: 20230141347
    Abstract: The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
    Type: Application
    Filed: July 22, 2022
    Publication date: May 11, 2023
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Paul Simmons
  • Publication number: 20230124294
    Abstract: The present disclosure relates to methods for preventing progressive heart failure in subjects with persistent left ventricular (LV) dysfunction. Such methods may also be used for treating or preventing progressive heart failure in subjects with a proximal left anterior descending (LAD) lesion and persistent left ventricular dysfunction.
    Type: Application
    Filed: October 12, 2022
    Publication date: April 20, 2023
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Lee Golden
  • Publication number: 20230104108
    Abstract: The present disclosure relates to method of treating or preventing inflammatory bowel disease (IBD) in a subject in need thereof, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs).
    Type: Application
    Filed: March 11, 2021
    Publication date: April 6, 2023
    Inventor: Silviu ITESCU
  • Publication number: 20230097931
    Abstract: The present disclosure relates to methods for treating or preventing chronic graft versus host disease in a subject in need thereof, the method comprising administering to the subject a composition comprising culture expanded mesenchymal lineage precursor or stem cells (MLPSCs).
    Type: Application
    Filed: February 18, 2021
    Publication date: March 30, 2023
    Inventor: Silviu ITESCU
  • Publication number: 20230030428
    Abstract: The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic applications.
    Type: Application
    Filed: March 9, 2022
    Publication date: February 2, 2023
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Paul Simmons
  • Patent number: 11491188
    Abstract: The present disclosure relates to methods for preventing progressive heart failure in subjects with persistent left ventricular (LV) dysfunction. Such methods may also be used for treating or preventing progressive heart failure in subjects with a proximal left anterior descending (LAD) lesion and persistent left ventricular dysfunction.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: November 8, 2022
    Assignee: MESOBLAST INTERNATIONAL SARL
    Inventors: Silviu Itescu, Lee Golden
  • Publication number: 20220275337
    Abstract: The present disclosure relates to cellular compositions that are modified to introduce a recombinant virus. Such compositions may be used to treat cancer by delivering vims to cancer cells.
    Type: Application
    Filed: August 5, 2020
    Publication date: September 1, 2022
    Inventors: Dan DEVINE, Nick LOIZOS, Silviu ITESCU
  • Patent number: 11406669
    Abstract: The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: August 9, 2022
    Assignees: MESOBLAST INTERNATIONAL SARL, OAKTREE FUND ADMINISTRATION, LLC
    Inventors: Silviu Itescu, Paul Simmons
  • Publication number: 20220226386
    Abstract: The present disclosure provides methods of treating a subject who has suffered a cerebral infarction, the method comprising administering systemically to the subject a population of cells enriched for mesenchymal lineage precursor or stem cells (MLPSCs) such as STRO-1+ cells or progeny thereof to increase stimulus-induced cortical activation or reduce infarct volume.
    Type: Application
    Filed: May 22, 2020
    Publication date: July 21, 2022
    Inventor: Silviu ITESCU