Abstract: A system and method for electrical stimulation of a body tissue. An array of microneedles, formed from an electrically conductive material are adapted for puncturing a surface of the tissue. A processing unit is configured to determine from a signal when the microneedles in the microneedle array are in a predetermined position in the tissue or when tissue surrounding one or more microneedles has been ablated.

Abstract: A vehicle radar system (110) that having a control unit (120) and a radar transceiver (130) that in turn including a controllable transmitter antenna arrangement (141). The control unit (120) is adapted to control the radar transceiver (130) to generate and transmit a radar signal (124), and receive a reflected radar signal (125). The control unit (120) is adapted to control the transmitter antenna arrangement (141) to generate a first antenna radiation pattern (160) for the transmitted radar signal (124), and to control the transmitter antenna arrangement (141) to generate a plurality of second antenna radiation patterns (161, 162, 163) for the transmitted radar signal (124). In a predetermined angular direction (?) is determined which second antenna radiation pattern (162) that provides the largest receive amplitude difference (?A2) between the first antenna radiation pattern (160) and the second antenna radiation patterns (161, 162, 163), and to choose that second antenna radiation pattern (162).

Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. the following compound: which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Abstract: A clock source outputs a clock signal. A first delay line receives a first clock source signal and produces a first output, the first clock source signal at least partially based on the clock signal. A first clock spine receives the first output and produces a global reference clock signal. A second delay line receives a second clock source signal and produces a second output, the second clock source signal at least partially based on the clock signal. A second clock spine receives the second output and produces a global feedback clock signal. A global phase detector detects a phase difference between the global reference clock signal and the global feedback clock signal to produce a global phase detector output. The second clock source signal is controlled at least partially based on the global phase detector output.

Abstract: Systems, methods, and computer-readable storage devices are disclosed for improving markerless motion analysis. One method including: receiving position data of joint centers of a body in motion captured by at least one camera; enhancing, using model equations, three-dimensional (3D) angular kinematic data of the position data of the joint centers of the body, wherein the enhanced 3D angular kinematic data includes increased measurement accuracy of the position data of the joint centers of the body; and providing the enhanced 3d angular kinematic data for display to evaluate motion performance.

Abstract: An incremental encoder apparatus including: a scale including a series of periodic features defining an optical incremental scale, and at least one magnetic reference mark; and a readhead. The readhead includes at least one incremental sensor configured to detect light from the optical incremental scale and to output at least one signal dependent thereon, and at least two analogue Hall sensors, each including at least two output terminal pairs, and each configured to switch repeatedly between each output terminal pair so as to reduce any inherent offset in the output of the analogue Hall sensor. The apparatus is configured to determine the presence of the reference mark from the outputs of the at least two analogue Hall sensors.

Abstract: The present application relates to current sensing circuitry (100) that comprises a differential amplifier (110) comprising first and second inputs configured to sense a current across a sense resistance, and an output configured to output a current sense signal. The circuitry (100) further comprises a first current source, a second current source and a switch network operable in: a first phase in which the first current source is connected to the first input and disconnected from the output, and the second current source is connected to the output and disconnected from the first input; and a second phase in which the first current source is connected to the output and disconnected from the first input, and the second current source is connected to the first input and disconnected from the output.

Abstract: A reusable shipper container has a container body with a payload chamber for holding goods and a lid operable to access the payload chamber. The reusable shipper container also has one or more sensors in the payload chamber to senses a humidity or temperature of the payload chamber or the goods. The reusable shipper container also has a tablet display screen detachably coupled to the container body that communicates with the sensors in the payload chamber.

Abstract: A tightening device for applying a preload to a fastening element, wherein the fastening element is suitable for fastening a diaphragm pump head part to a drive system for impressing movement on a diaphragm of the diaphragm pump head part in a device for conveying fluid. The tightening device has a support with support surface for supporting a bearing surface of the fastening element, wherein the support has a threaded bore through which a screw element penetrates. The screw element has a contact surface at its front end, wherein the contact surface of the screw element and the support surface of the support face opposite directions, and the distance between the contact surface of the screw element and the support surface of the support can be changed by screwing in or unscrewing the screw element.

Abstract: The present invention provides acyl sulfonamide compounds of general formula (I): in which X, R1, R2, R3, R4, R5, R6? Ra and Rb are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treating and/or prophylaxing diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.

Abstract: An integrated filter optical package including an ambient light sensor that incorporates an infrared (IR) filter in an integrated circuit (IC) stacked-die configuration is provided. The integrated filter optical package incorporates an infrared (IR) coated glass layer to filter out or block IR light while allowing visible (ambient) light to pass through to a light sensitive die having a light sensor. The ambient light sensor detects an amount of visible light that passes through the IR coated glass layer and adjusts a brightness or intensity of a display screen on an electronic device accordingly so that the display screen is readable.

Abstract: An assembly for a diaphragm pump includes: a body defining a plurality of diaphragm chambers spaced apart about a body axis, wherein each diaphragm chamber defines a membrane opening, an inlet chamber in fluid communication with each diaphragm chamber, and an outlet chamber in fluid communication with each diaphragm chamber; and a plurality of flexible membranes that each comprise an outer edge, wherein the body is configured to clamp the outer edge of each membrane along a corresponding membrane opening to seal a corresponding one of the diaphragm chambers; wherein the membranes are configured to deflect substantially in parallel to the body axis to suction fluid into each diaphragm chamber from the inlet chamber and discharge fluid from each diaphragm chamber into the outlet chamber; wherein each membrane comprises a coupling section configured to couple the membrane to a pump drive and arranged along a diaphragm axis that extends in parallel to the body axis, and a deflection section arranged radially outw

Abstract: A method for multi-view dataset formation from fleet data is described. The method includes detecting at least a pair of vehicles within a vicinity of one another, and having overlapping viewing frustums of a scene. The method also includes triggering a capture of sensor data from the pair of vehicles. The method further includes synchronizing the sensor data captured by the pair of vehicles. The method also includes registering the sensor data captured by the pair of vehicles within a shared coordinate system to form a multi-view dataset of the scene.

Abstract: A bottom structure for an electric vehicle including at least a first and second beam-shaped battery modules extending in a length direction. Each module is formed by a number interconnected cells and has two longitudinal sides, two transverse sides and a top side covered by a cover plate. The modules are mutually interconnected along their longitudinal sides via an adhesive.

Abstract: Disclosed herein are embodiments of a method for treating a disease or condition in a subject, comprising administering to the subject, a pyrazole compound according to formula I. The compound may be administered as a composition, such as a spray-dried formulation. The disease or condition may be hidradenitis suppurativa, or a lymphoid neoplasm, and may be chronic myeloid leukemia or chronic myelomonocytic leukemia.

Abstract: A system for recommending and optimizing artificial intelligence (AI) workload placement in a multi-vendor cloud environment is disclosed. The system utilizes a server with at least one processor to access input datasets stored in a datacentre associated with an AI workload and determine suitable processing units from various manufacturers based on predefined criteria. It calculates the required number of processing units and accesses a multi-vendor performance database. A deep learning model predicts infrastructure requirements for the AI workload, enabling the generation of recommendations for optimal processing unit configuration. The system automatically allocates processing unit resources from multiple manufacturers based on these recommendations. Finally, it generates data for a user interface dashboard, presenting information about manufacturers, processing unit types, recommended configurations, and real-time performance metrics of allocated resources.