Patents by Inventor Sina Ghaemmaghami

Sina Ghaemmaghami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9677068
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: June 13, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Patent number: 9658213
    Abstract: An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the subject in order to ensure that the subject incorporates a large percentage of isotopically labeled amino acids into newly synthesized proteins. Tissue samples are removed from the subject at different points in time and proteins are extracted and separated so that different proteins of different tissues can be individually analyzed and their amount and pattern of isotopic labeling can be determined. In a preferred embodiment, the methodology can be combined with proteolytic digestion to peptides and analysis by mass spectrometry in order to measure rates of protein turnover in vivo relating to thousands of different proteins.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: May 23, 2017
    Assignee: The Regents of the University of California
    Inventors: Stanley B. Prusiner, John C. Price, Sina Ghaemmaghami, Al Burlingame, Shenheng Guan
  • Publication number: 20160326519
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Application
    Filed: February 5, 2016
    Publication date: November 10, 2016
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Patent number: 9284547
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: March 15, 2016
    Assignee: The Regents of the University of California
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Publication number: 20140287957
    Abstract: An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the subject in order to ensure that the subject incorporates a large percentage of isotopically labeled amino acids into newly synthesized proteins. Tissue samples are removed from the subject at different points in time and proteins are extracted and separated so that different proteins of different tissues can be individually analyzed and their amount and pattern of isotopic labeling can be determined. In a preferred embodiment, the methodology can be combined with proteolytic digestion to peptides and analysis by mass spectrometry in order to measure rates of protein turnover in vivo relating to thousands of different proteins.
    Type: Application
    Filed: June 17, 2011
    Publication date: September 25, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Stanley B. Prusiner, John C. Price, Sina Ghaemmaghami, Al Burlingame, Shenheng Guan
  • Publication number: 20130288905
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Application
    Filed: April 22, 2013
    Publication date: October 31, 2013
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Patent number: 8486865
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: July 16, 2013
    Assignee: The Regents of the University of California
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Publication number: 20100120625
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Application
    Filed: November 3, 2009
    Publication date: May 13, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: JONATHAN WEISSMAN, NICHOLAS INGOLIA, SINA GHAEMMAGHAMI, JOHN R. S. NEWMAN
  • Patent number: 7413906
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: August 19, 2008
    Assignee: Duke University
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald
  • Publication number: 20070099305
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Application
    Filed: December 5, 2006
    Publication date: May 3, 2007
    Inventors: Terence Oas, Sina Ghaemmaghami, Kendall Powell, Michael Fitzgerald
  • Patent number: 7148071
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: December 12, 2006
    Assignee: Duke University
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald
  • Publication number: 20040157266
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Application
    Filed: March 18, 2004
    Publication date: August 12, 2004
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald
  • Patent number: 6734023
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: May 11, 2004
    Assignee: Duke University
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald