Patents by Inventor Sinan Güven

Sinan Güven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scaffold-free 3D cell assembly based on patterned hydrodynamic drag force
    Patent number: 10465161
    Abstract: A method of making a multi-layer patterned cell assembly is provided. A cell suspension liquid solution containing cells is loaded into a liquid-carrier chamber. The cells in the cell suspension liquid solution are let to settle down to the bottom of the chamber. Once the cells in the cell suspension liquid solution have gravitationally settled down to the bottom of the chamber, a hydrodynamic drag force is applied by using a vibration generator with a frequency and acceleration to the cells at the bottom of the chamber. The frequency and acceleration are designed to drag the settled cells into a three-dimensional pattern to form a multi-layer three-dimensional patterned cell assembly. The formed multi-layer three- dimensional patterned cell assembly can be transferred from the liquid-carrier chamber to an incubator to form a tissue culture. The bioengineered construct can be implanted for tissue engineering or other medical applications.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: November 5, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Pu Chen, Utkan Demirci, Sinan Güven
  • Scaffold-free 3D Cell Assembly based on patterned Hydrodynamic Drag Force
    Publication number: 20170226473
    Abstract: A method of making a multi-layer patterned cell assembly is provided. A cell suspension liquid solution containing cells is loaded into a liquid-carrier chamber. The cells in the cell suspension liquid solution are let to settle down to the bottom of the chamber. Once the cells in the cell suspension liquid solution have gravitationally settled down to the bottom of the chamber, a hydrodynamic drag force is applied by using a vibration generator with a frequency and acceleration to the cells at the bottom of the chamber. The frequency and acceleration are designed to drag the settled cells into a three-dimensional pattern to form a multi-layer three-dimensional patterned cell assembly. The formed multi-layer three- dimensional patterned cell assembly can be transferred from the liquid-carrier chamber to an incubator to form a tissue culture. The bioengineered construct can be implanted for tissue engineering or other medical applications.
    Type: Application
    Filed: October 26, 2015
    Publication date: August 10, 2017
    Inventors: Pu Chen, Utkan Demirci, Sinan Güven