Patents by Inventor Siobhan Cashman

Siobhan Cashman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS, METHODS AND KITS FOR TREATING COMPLEMENT RELATED DISORDERS
    Publication number: 20230414714
    Abstract: Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55 protein and a CD59 protein or with a recombinant chimeric protein having at least two of a CD46 protein, a CD55 protein and a CD59 protein or with nucleic acids encoding these proteins. The composition negatively modulates classical and alternative complement pathways thereby treating complement related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinaemia, fetal loss, organ graft rejection, cancer, etc.
    Type: Application
    Filed: May 19, 2023
    Publication date: December 28, 2023
    Inventors: Rajendra Kumar-Singh, Derek Leaderer, Siobhan Cashman
  • Compositions, methods and kits for treating complement related disorders
    Patent number: 10813977
    Abstract: Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55 protein and a CD59 protein or with a recombinant chimeric protein having at least two of a CD46 protein, a CD55 protein and a CD59 protein or with nucleic acids encoding these proteins. The composition negatively modulates classical and alternative complement pathways thereby treating complement related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinaemia, fetal loss, organ graft rejection, cancer, etc.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: October 27, 2020
    Assignee: Trustees of Tufts College
    Inventors: Rajendra Kumar-Singh, Derek Leaderer, Siobhan Cashman
  • Compositions, methods and kits for treating complement related disorders
    Publication number: 20170209535
    Abstract: Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55 protein and a CD59 protein or with a recombinant chimeric protein having at least two of a CD46 protein, a CD55 protein and a CD59 protein or with nucleic acids encoding these proteins. The composition negatively modulates classical and alternative complement pathways thereby treating complement related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinaemia, fetal loss, organ graft rejection, cancer, etc.
    Type: Application
    Filed: February 28, 2017
    Publication date: July 27, 2017
    Applicant: TUFTS UNIVERSITY
    Inventors: Rajendra Kumar-Singh, Derek Leaderer, Siobhan Cashman