Patents by Inventor Sonia Colombo Serra

Sonia Colombo Serra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RATIOMETRIC PULSED CEST IMAGING
    Publication number: 20210263122
    Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 26, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
  • RATIOMETRIC PULSED CEST IMAGING
    Publication number: 20200379070
    Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
    Type: Application
    Filed: December 22, 2016
    Publication date: December 3, 2020
    Applicant: Bracco Imaging S.p.A.
    Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
  • Hyperpolarized 1-13C-1,1-bis(acetoxy(methyl))-2,2?-cyclopropane as metabolic marker for MR
    Patent number: 10583209
    Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 10, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Mathilde H. Lerche, Pernille Rose Jensen, Magnus Karlsson, Roberta Napolitano, Claudia Cabella, Luigi Miragoli, Sonia Colombo Serra, Fabio Tedoldi
  • HYPERPOLARIZED 1-13C-1,1-BIS(ACETOXY(METHYL))-2,2'-CYCLOPROPANE AS METABOLIC MARKER FOR MR
    Publication number: 20190275180
    Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
    Type: Application
    Filed: March 25, 2019
    Publication date: September 12, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Mathilde H. LERCHE, Pernille Rose JENSEN, Magnus KARLSSON, Roberta NAPOLITANO, Claudia CABELLA, Luigi MIRAGOLI, Sonia COLOMBO SERRA, Fabio TEDOLDI
  • Hyperpolarized esters as metabolic markers in MR
    Patent number: 10265421
    Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: April 23, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Lerche H. Mathilde, Magnus Karlsson, Claudia Cabella, Sonia Colombo Serra, Luigi Miragoli, Luca Venturi, Fabio Tedoldi
  • PREPARATION OF SOLID AMORPHOUS SUBSTRATES FOR DNP
    Publication number: 20170252464
    Abstract: A method for preparing a sample for dynamic nuclear polarization which comprises submitting a solid substrate to a milling process in the presence of a polarizing agent at a temperature lower than the glass-transition temperature (Tg) of said substrate. Preferably said substrate may be in crystalline form.
    Type: Application
    Filed: July 22, 2015
    Publication date: September 7, 2017
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Elena ELISEI, Attilio CESARO, Marta FILIBIAN, Pietro CARRETTA, Sonia COLOMBO SERRA, Alessandro MAIOCCHI, Fabio TEDOLDI
  • Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
    Patent number: 9693828
    Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 4, 2017
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
  • Process for the preparation of hyperpolarized derivatives for use in MRI analysis
    Patent number: 9511154
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: December 6, 2016
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi
  • HYPERPOLARIZED 1-13C-1,1-BIS(ACETOXY(METHYL))-2,2'-CYCLOPROPANE AS METABOLIC MARKER FOR MR
    Publication number: 20160296645
    Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
    Type: Application
    Filed: June 30, 2014
    Publication date: October 13, 2016
    Applicant: BRACCO IMAGING S.P.A
    Inventors: Mathilde H. Lerche, Pernille Rose JENSEN, Magnus KARLSSON, Roberta NAPOLITANO, Claudia CABELLA, Luigi MIRAGOLI, Sonia COLOMBO SERRA, Fabio TEDOLDI
  • HYPERPOLARIZED ESTERS AS METABOLIC MARKERS IN MR
    Publication number: 20150374854
    Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.
    Type: Application
    Filed: January 30, 2014
    Publication date: December 31, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose JENSEN, LERCHE H. Mathilde, Magnus KARLSSON, Claudia CABELLA, Sonia COLOMBO SERRA, Luigi MIRAGOLI, Luca VENTURI, Fabio TEDOLDI
  • HYPERPOLARIZED 2-OXOGLUTARATE AS METABOLIC AGENT IN MR
    Publication number: 20150273086
    Abstract: Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from 13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy.
    Type: Application
    Filed: October 24, 2013
    Publication date: October 1, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Claudia Cabella, Lara Caminiti, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Luigi Miragoli, Luisa Poggi, Fabio Tedoldi, Luca Venturi
  • Composition Comprising Acetic Anhydride And A Gadolinium Complex, And Method For The Use In Hyperpolarisation In MRI Analysis
    Publication number: 20140343402
    Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
    Type: Application
    Filed: December 3, 2012
    Publication date: November 20, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
  • Process For The Preparation Of Hyperpolarized Derivatives For Use In MRI Analysis
    Publication number: 20140257085
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.
    Type: Application
    Filed: October 11, 2012
    Publication date: September 11, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi