Patents by Inventor Soong-Hoon Kim

Soong-Hoon Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040023345
    Abstract: The present invention relates to a process for the preparation of intermediates useful in the synthesis of epothilone analogs by initially enzymatically degrading certain epothilone compounds to form ring-open structures containing a carboxyl group which is esterified, the hydroxyl groups on the moiety protected and the resulting compound oxidized by, e.g. ozone, to form a first intermediate. The first intermediate can be reacted with a triphenylphosphine adduct to yield a compound containing an ester group at position 1 which is subsequently hydrolyzed to form a second intermediate.
    Type: Application
    Filed: May 28, 2003
    Publication date: February 5, 2004
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Hofle
  • Publication number: 20040024001
    Abstract: Compound having the formula (I), 1
    Type: Application
    Filed: April 25, 2003
    Publication date: February 5, 2004
    Inventors: William J. Pitts, Soong-Hoon Kim, Joseph Barbosa, Wayne Vaccaro
  • Publication number: 20030220295
    Abstract: The present invention relates to compounds of the formula 1
    Type: Application
    Filed: April 3, 2003
    Publication date: November 27, 2003
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Robert M. Borzilleri, James A. Johnson
  • Publication number: 20030191089
    Abstract: The present invention relates to compounds useful in the treatment of cancer or other proliferative diseases represented by formula I: 1
    Type: Application
    Filed: March 11, 2003
    Publication date: October 9, 2003
    Inventors: Alicia Regueiro-Ren, Soong-Hoon Kim
  • Patent number: 6605599
    Abstract: The present invention relates to epothilone derivatives, having the following formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: August 12, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Robert M. Borzilleri, James A. Johnson
  • Patent number: 6602883
    Abstract: Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: August 5, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Charles Z. Ding, John T. Hunt, Soong-Hoon Kim, Katerina Leftheris
  • Patent number: 6593115
    Abstract: The present invention relates to a process for the preparation of intermediates useful in the synthesis of epothilone analogs by initially enzymatically degrading certain epothilone compounds to form ring-open structures containing a carboxyl group which is esterified, the hydroxyl groups on the moiety protected and the resulting compound oxidized by, e.g. ozone, to form a first intermediate. The first intermediate can be reacted with a triphenylphosphine adduct to yield a compound containing an ester group at position 1 which is subsequently hydrolyzed to form a second intermediate.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: July 15, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Höfle
  • Publication number: 20030087888
    Abstract: The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor.
    Type: Application
    Filed: May 14, 2002
    Publication date: May 8, 2003
    Inventors: Alicia Regueiro-Ren, Robert M. Borzilleri, Gregory D. Vite, Soong-Hoon Kim
  • Patent number: 6455523
    Abstract: Inhibition of farnesyl transferase, which is an enzyme involved in ras ocogene expression, is effected by compounds of the formulas their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof inhibit farnesyl protein transferase which is an enzyme involved in ras oncogene expression.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: September 24, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Charles Z. Ding, Soong-Hoon Kim, John T. Hunt, Toomas Mitt, Rajeev Bhide, Katerina Leftheris
  • Patent number: 6399638
    Abstract: The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: June 4, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Höfle
  • Patent number: 6387926
    Abstract: Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: May 14, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Charles Z. Ding, John T. Hunt, Soong-Hoon Kim, Katerina Leftheris
  • Patent number: 6380395
    Abstract: The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 30, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Höfle
  • Publication number: 20020042109
    Abstract: The present invention relates to a process for the preparation of intermediates useful in the synthesis of epothilone analogs by initially enzymatically degrading certain epothilone compounds to form ring-open structures containing a carboxyl group which is esterified, the hydroxyl groups on the moiety protected and the resulting compound oxidized by, e.g. ozone, to form a first intermediate. The first intermediate can be reacted with a triphenylphosphine adduct to yield a compound containing an ester group at position 1 which is subsequently hydrolyzed to form a second intermediate.
    Type: Application
    Filed: March 19, 2001
    Publication date: April 11, 2002
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Hofle
  • Patent number: 6365749
    Abstract: The present invention relates to a process to produce ring opened epothilones and the novel ring opened epothilones produced thereform.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: April 2, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Soong-Hoon Kim, Robert M. Borzilleri
  • Patent number: 6320045
    Abstract: The invention as claimed is directed to a process for making an epothilone having the following structures from ones having an oxiranyl moiety, by reacting a compound having the latter structure with a metal or metal-assisted reagent. Said metal or metal-assisted reagent is selected from the group consisting of a) reactive metallocenes; b) [N2C(CO2Me)2, cat Rh2,(OAC)4]; c) [N2C(CO2Me)2, cat[(n-C7H15CO2)2 Rh]2]; d) [Zn—Cu, EtOH]; e) [Mg(Hg), MgBr]; f) Cr; g) [FeCl3, n-BuLi]; h) [TiCl3, LiAlH4]; i) [TiCl4, Zn]; j) [WCl6, LiAlH4,]; k) [NbCl5, NaAlH4]; l) [VCl3,Zn] and m) [WCl6, n-BuLi].
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: November 20, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Soong-Hoon Kim, James A. Johnson
  • Publication number: 20010031880
    Abstract: The present invention relates to a stereospecific process to produce aziridinyl epothilones from oxiranyl epothilones and the intermediates derived therein.
    Type: Application
    Filed: March 17, 2000
    Publication date: October 18, 2001
    Inventors: Robert M. Borzilleri, Soong-Hoon Kim, Alicia Regueiro-Ren, Gregory D. Vite
  • Patent number: 6291684
    Abstract: The present invention relates to a stereospecific process to produce aziridinyl epothilones from oxiranyl epothilones and the intermediates derived therein.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 18, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Soong-Hoon Kim, Alicia Regueiro-Ren, Gregory D. Vite
  • Patent number: 6262094
    Abstract: The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: July 17, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gerhard Hoefle, Nicole Glaser, Thomas Leibold, Gregory Vite, Soong-Hoon Kim
  • Patent number: 6011029
    Abstract: The present invention comprises benzodiazepine compounds having farnesyl transferase inhibitory activity.
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: January 4, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Charles Z. Ding, Soong-Hoon Kim, John T. Hunt, Toomas Mitt, Rajeev Bhide, Katerina Leftheris