Abstract: An interface between the external and internal environments associated with an essentially closed system, such as a human body, comprises an oral implant. The oral implant includes one or more chambers capable of containing materials delivered and/or receiving materials extracted by the implant. Micro- and nano-mechanical and electro-mechanical components, such as microfluidic pumps, perform the mechanics of the delivery and/or extraction of material via the oral implant. Miniature testing devices, such as a “lab-on-a-chip”, can be associated with the oral implant to perform in situ testing on material extracted via the implant. Communications means, including wireless communications, associated with the oral implant allow for remote control of the implant and/or remote reporting of information associated with the implant, such as test results.