Patents by Inventor Sowmianarayanan Ramaswamy

Sowmianarayanan Ramaswamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes and intermediates for resolving piperidyl acetamide stereoisomers
    Patent number: 7459560
    Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: December 2, 2008
    Assignee: Celgene Corporation
    Inventors: Vikram Khetani, Yalin Luo, Sowmianarayanan Ramaswamy
  • Processes and intermediates for resolving piperidyl acetamide stereoisomers
    Publication number: 20060142583
    Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.
    Type: Application
    Filed: February 23, 2006
    Publication date: June 29, 2006
    Inventors: Vikram Khetani, Yalin Luo, Sowmianarayanan Ramaswamy
  • Process and intermediates for resolving piperidyl acetamide steroisomers
    Patent number: 6962997
    Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: November 8, 2005
    Assignee: Celgene Corporation
    Inventors: Vikram Khetani, Yalin Luo, Sowmianarayanan Ramaswamy
  • Processes and intermediates for resolving piperidyl acetamide stereoisomers
    Publication number: 20050014790
    Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.
    Type: Application
    Filed: August 11, 2004
    Publication date: January 20, 2005
    Inventors: Vikram Khetani, Yalin Luo, Sowmianarayanan Ramaswamy
  • Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
    Patent number: 6025516
    Abstract: The present invention provides an efficient route to the C-13 side chain of the anti-cancer drug paclitaxel (TAXOL) and its analogs. The process includes the resolution of racemic erythro 2-hydroxy-3-amino-3-phenylpropionamide by diastereomeric crystallization and its conversion via various intermediates to the threo-ethylester and threo-methylester isomers.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: February 15, 2000
    Assignee: Chiragene, Inc.
    Inventors: Sowmianarayanan Ramaswamy, Venkat G. Reddy, Yalin Luo
  • Processes and intermediates for preparing 2-substituted piperidine stereoisomers
    Patent number: 5965734
    Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided. In preferred embodiments, the processes of the invention comprise the steps of reacting a 2-substituted pyridine with hydrogen in the presence of a catalyst in an alkanoic acid, and adding an alkyl alkanoate to the resulting mixture of threo and erythro 2-piperidine stereoisomers to precipitate alkanoate salts of the erythro stereoisomers preferentially with respect to alkanoate salts of the threo stereoisomers. The erythro salts then are reacted with aqueous base to form the corresponding mixture of erythro amide free bases, which are reacted with a suitable organic acid resolving agent in an alkyl alcohol solvent to form acid salts of the l-erythro stereoisomers preferentially with respect to the d-erythro stereoisomers.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: October 12, 1999
    Assignee: Celgene Corporation
    Inventors: Sowmianarayanan Ramaswamy, Vikram Khetani
  • Processes and intermediates for resolving piperidyl acetamide stereoisomers
    Patent number: 5936091
    Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: August 10, 1999
    Assignee: Celgene Corporation
    Inventors: Vikram Khetani, Yalin Luo, Sowmianarayanan Ramaswamy