Patents by Inventor Stacey Jones

Stacey Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ORPHAN NUCLEAR RECEPTOR
    Publication number: 20120283412
    Abstract: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
    Type: Application
    Filed: July 16, 2012
    Publication date: November 8, 2012
    Inventors: Steven A. Kliewer, Stacey A. Jones, Timothy M. Willson
  • Orphan nuclear receptor
    Patent number: 8221991
    Abstract: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: July 17, 2012
    Assignee: GlaxoSmithKline LLC
    Inventors: Steven A. Kliewer, Stacey A. Jones, Timothy M. Willson
  • Orphan Nuclear Receptor
    Publication number: 20110059478
    Abstract: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
    Type: Application
    Filed: September 8, 2010
    Publication date: March 10, 2011
    Inventors: Steven A. Kliewer, Stacey A. Jones, Timothy M. Willson
  • Orphan Nuclear Receptor
    Publication number: 20080096239
    Abstract: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monoxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
    Type: Application
    Filed: June 22, 2007
    Publication date: April 24, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Steven Kliewer, Stacey Jones, Timothy Willson
  • Pregnane X receptor method
    Patent number: 7238491
    Abstract: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: July 3, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Steven A. Kliewer, Stacey A. Jones, Timothy M. Willson
  • Compositions and methods for treatment of fibrosis
    Publication number: 20070015796
    Abstract: Methods for the treatment of fibrosis, including liver fibrosis, via administration of FXR agonists are provided.
    Type: Application
    Filed: September 10, 2004
    Publication date: January 18, 2007
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Stacey Jones, Yaping Liu, John Moore
  • Methods of using farnesoid x receptor (frx) agonists
    Publication number: 20050107475
    Abstract: Treatment of human hepatocytes with farnesoid X receptor (FXR) agonists resulted in increased expression of FGF-19. Methods of using FXR agonists to alter cell metabolism, and in pharmaceutical weight loss methods, are described.
    Type: Application
    Filed: March 19, 2003
    Publication date: May 19, 2005
    Inventors: Stacey Jones, Steven Kliewer, Traci Mansfield