Patents by Inventor Stanislava Pokorna

Stanislava Pokorna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof
    Patent number: 4720497
    Abstract: 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, ##STR1## in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula II (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The subject compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently have great potential for the treatment of malignant neoplastic diseases in mammals.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: January 19, 1988
    Assignee: SPOFA, Spojene Podniky pro Zdravotnickou Vyrobu
    Inventors: Antonin Cerny, Jiri Krepelka, Milan Melka, Milan Miko, Stanislava Pokorna, Ruzena Reichlova, Irena Kejhova, Marta Beitova, Jaroslava Grimova
  • Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for their production
    Patent number: 4661297
    Abstract: Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.
    Type: Grant
    Filed: September 14, 1982
    Date of Patent: April 28, 1987
    Assignee: SPOFA, spojene podniky pro zdravotnickou vyrobu
    Inventors: Jiri Krepelka, Iva Vancurova, Karel Rezabek, Milan Melka, Vojtech Pujman, Stanislava Pokorna, Ruzena Reichlova, Slavjanka Cernochova