Abstract: A myocardial implant for insertion into a heart wall for trans myocardial revascularization (TMR) of the heart wall. The TMR implant provides for means to promote the formation of new blood vessels (angiogenesis), and has a flexible, elongated body that contains a cavity and openings through the flexible, elongated body from the cavity. The TMR implant includes a coaxial anchoring element integrally formed at one end for securing the TMR implant in the heart wall.

Abstract: A stent for insertion into a heart wall for Trans Myocardial Revascularization (TMR) thereof. The TMR stent provides for the delivery of blood nutrients from a heart chamber into the heart wall and has an elongated body which may contain a cavity and openings through the elongated body from the cavity. The elongated body should be in fluid communication with the heart chamber. If a cavity and openings are provided, the openings are in fluid communication with the heart chamber, the cavity and the heart wall. The TMR stent may include an anchoring element integrally formed thereon for securing the TMR stent in the heart wall.

Abstract: A delivery device for insertion of a myocardial implant into a heart wall for trans myocardial revascularization (TMR) of the heart wall. The delivery device provides for the exact placement of one or more TMR implants into a heart wall, and has an elongated, tubular body that may include spaced-apart ports and a connecting conduit. A needle point is formed at one end to pierce the heart wall, and a handle is formed at another end to manipulate the device. The delivery device may include a surrounding sheath into which the needle point and a needle assembly may be withdrawn to release the TMR implant in the heart wall, and withdraw the delivery device from a person's body. The sheath may include a locking portion for holding the TMR implant in position when releasing the implant in a heart wall.

Abstract: A stent for insertion into a heart wall for Trans Myocardial Revascularization (TMR) thereof. The TMR stent provides for the delivery of blood nutrients from a heart chamber into the heart wall and has an elongated body which may contain a cavity and openings through the elongated body from the cavity. The elongated body should be in fluid communication with the heart chamber. If a cavity and openings are provided, the openings are in fluid communication with the heart chamber, the cavity and the heart wall. The TMR stent may include an anchoring element integrally formed thereon for securing the TMR stent in the heart wall.

Abstract: A stent for insertion into a heart wall for Trans Myocardial Revascularization (TMR) thereof. The TMR stent provides for the delivery of blood nutrients from a heart chamber into the heart wall and has an elongated body which may contain a cavity and openings through the elongated body from the cavity. The elongated body should be in fluid communication with the heart chamber. If a cavity and openings are provided, the openings are in fluid communication with the heart chamber, the cavity and the heart wall. The TMR stent may include an anchoring element integrally formed thereon for securing the TMR stent in the heart wall.

Abstract: A medical device and method are provided for generating deep coagulation necrosis as well as surface vaporization in the site of a body cavity. The device provides means for delivering laser energy from the side of the device while providing localized irrigation at its laser delivery port. Laser energy is delivered from a fiberoptic that is bent at its distal end and placed in a catheter body which includes an irrigation channel that terminates at the distal end of that fiberoptic. Deep coagulation necrosis is achieved by: a) placement under endoscopic guidance of the device in the body cavity, b) delivering a predetermined dose of laser energy to target tissue, and c) rotating the device continuously during laser delivery, with at least one revolution in one direction. After the coagulation session has been completed, a detachable heat-generating cap may be mounted at the distal end of the catheter in order to convert the direct laser energy into controlled thermal energy at the surface of that cap.

Abstract: A heart tissue mapping and lasing catheter well suited for control of tachyarrhythmias is disclosed. A distal end region of the catheter has an electrode envelope constituted by plural surface electrode pairs spaced from one another and is provided with at least one fiber optic within the electrode envelope. The emissive face of the fiber optic is situated between adjacent electrode pairs in the electrode envelope.

Abstract: A method and device are provided for directing laser radiation to a body cavity site. A hollow, elongate, optical fiber is advanced, usually in a containing device, to the vicinity of the site and coupled to a laser source with a distal end region of the fiber extending along a longitudinal axis. The fiber terminates in an energy delivery surface for emitting laser radiation transmitted by the fiber. The radiation is intercepted at a location axially aligned with the energy delivery surface and is reflected in a beam radiating substantially transversely of, and substantially circumferentially around, the axis. A reflector member or block is provided for reflecting the radiation and is mounted in an open end of the catheter at a selected axial position along the axis. A fluid, such as a flushing fluid, can be directed between the end of the fiber, against the reflector member, and to the body site.

Abstract: A method and device are provided for directing laser radiation to a body cavity site. A hollow, elongate, optical fiber is advanced to the vicinity of the site and coupled to a laser source with a distal end region of the fiber extending along a longitudinal axis. The fiber terminates in a transverse, substantially flat, annular, energy delivery surface for emitting laser radiation transmitted by the fiber generally parallel to the axis. The radiation is intercepted axially adjacent the energy delivery surface and is reflected in a beam radiating substantially transversely of, and substantially around, the axis. A reflector block is provided for reflecting the radiation and is connected to an actuator for locating the reflector block at selected axial positions along the axis whereby the beam irradiates the body site along the axis.

Abstract: A medical device for applying localized heat to a site in a patient's body is described. The device includes a radiant energy transmitting conduit, e.g., a fiber optic, and a heat generating element which converts the transmitted radiant energy into heat. A suitable exterior guide member can also be provided for positioning the heat generating element. An opening can be provided in the heat generating element to enable a portion of the radiant energy to impinge directly upon the site. The medical device can be used to cauterize or destroy tissue, or to alter or remove undesirable deposits from lumens. The medical device can also serve as part of a system which provides the radiant energy and measures the temperature of the heat generating element while within the patient.

Abstract: A medical device for applying localized heat to a site in a patient'body is described. The device includes a radiant energy transmitting conduit, e.g., a fiber optic, and a heat generating element which converts the transmitted radiant energy into heat. A suitable exterior guide member can also be provided for positioning the heat generating element. An opening can be provided in the heat generating element to enable a portion of the radiant energy to impinge directly upon the site. The medical device can be used to cauterize or destroy tissue, or to alter or remove undesirable deposits from lumens. The medical device can also serve as part of a system which provides the radiant energy and measures the temperature of the heat generating element while within the patient.

Abstract: A sequential medication delivery device for intravenous administration of plural medications is disclosed. A secondary medication can be administered to a patient followed by an automatic resumption of the delivery of the primary medication at a predetermined flow rate. The disclosed medication delivery device includes an internal valving system and an associated medication chamber that contains the secondary medication to be delivered. While the medication chamber contains such secondary medication, the flow of primary medication to the patient is interrupted. However, once the medication chamber has been substantially emptied the flow of primary medication to the patient is resumed automatically.