Patents by Inventor Stanley J. Szymanski, Jr.

Stanley J. Szymanski, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8778996
    Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) seizures, myoclonic seizures, epilepsy, refractory epilepsy, hyperkinetic movements or tremors of hands or feet, (2) a state of ataxia, (3) accumulation of neuronal autofluorescent storage bodies in lysosomes or neurons, or regression of motor development, and (4) low alertness, dementia or mental retardation. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: July 15, 2014
    Assignees: ChemGenes Corporation
    Inventors: Suresh C. Srivastava, Sant K. Srivastav, Stanley J. Szymanski, Jr.
  • Patent number: 8518992
    Abstract: The invention provides a method of synthesis of N-6-trimethyl-L-lysine (TML) derivative compounds for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: August 27, 2013
    Inventors: Suresh C. Srivastava, Sant K. Srivastav, Stanley J. Szymanski, Jr.
  • Patent number: 8389577
    Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) a clinical state of impairment of carnitine or carnitine esters, or decreased fatty acid metabolism, (2) low energy production or lower ATP production, (3) clinical hyperammonemia, and (4) clinically high pyruvate levels resulting from a deficiency in the biosynthesis of carnitine. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: March 5, 2013
    Inventors: Suresh C. Srivastava, Sant K. Srivastav, Stanley J. Szymanski, Jr.
  • Publication number: 20110166380
    Abstract: The invention provides derivative compounds of N-6-trimethyl-L-lysine (TML) for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.
    Type: Application
    Filed: March 9, 2011
    Publication date: July 7, 2011
    Inventors: Suresh C. Srivastava, Sant K. Srivastay, Stanley J. Szymanski, JR.
  • Publication number: 20110166379
    Abstract: The invention provides a method of synthesis of N-6-trimethyl-L-lysine (TML) derivative compounds for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.
    Type: Application
    Filed: March 9, 2011
    Publication date: July 7, 2011
    Inventors: Suresh C. Srivastava, Sant K. Srivastav, Stanley J. Szymanski, JR.
  • Publication number: 20110166230
    Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) seizures, myoclonic seizures, epilepsy, refractory epilepsy, hyperkinetic movements or tremors of hands or feet, (2) a state of ataxia, (3) accumulation of neuronal autofluorescent storage bodies in lysosomes or neurons, or regression of motor development, and (4) low alertness, dementia or mental retardation. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.
    Type: Application
    Filed: March 9, 2011
    Publication date: July 7, 2011
    Inventors: Suresh C. Srivastava, Sant K. Srivastav, Stanley J. Szymanski, JR.
  • Publication number: 20110166231
    Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) a clinical state of impairment of carnitine or carnitine esters, or decreased fatty acid metabolism, (2) low energy production or lower ATP production, (3) clinical hyperammonemia, and (4) clinically high pyruvate levels resulting from a deficiency in the biosynthesis of carnitine. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.
    Type: Application
    Filed: March 9, 2011
    Publication date: July 7, 2011
    Inventors: Suresh C. Srivastava, Sant K. Srivastav, Stanley J. Szymanski, JR.
  • Patent number: 7932287
    Abstract: The invention provides compositions for and methods of treating a number of disorders. In one embodiment, the invention provides a method of treating a wide range of conditions by administering to a human being in need of such treatment, a therapeutically effective amount of (a) N-6-trimethyl-L-lysine of at least 98% purity, (b) a prodrug thereof, (c) an aliphatic chain derivative thereof, (d) an ester derivative thereof, (e) an amide derivative thereof, or (f) a pharmaceutically acceptable salt of said N-6-trimethyl-L-lysine or said prodrug.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: April 26, 2011
    Assignees: ChemGenes Corporation
    Inventors: Suresh C. Srivastava, Sant K. Srivastav, Stanley J. Szymanski, Jr.