Patents by Inventor Stanley Leon HAZEN

Stanley Leon HAZEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for inhibiting conversion of choline to trimethylamine (TMA)
    Patent number: 11331280
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising (2-hydroxyethyl) dimethylsulfonium with a counterion wherein the counterion is selected from chloride, bromide or iodide.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: May 17, 2022
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Stanley Leon Hazen, Jose Carlos Garcia-Garcia, Jodie Michelle Reed, Lori Ann Reinsalu, Vincent Peter Sica, Timothy R Baker
  • Methods for inhibiting conversion of choline to trimethylamine (TMA)
    Patent number: 11246844
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: February 15, 2022
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Stanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, Xiaodong Gu, Michael Reilly, Mark Robert Sivik, Jodie Michelle Reed, David Blair Cody
  • Methods for inhibiting conversion of choline to trimethylamine (TMA)
    Patent number: 10849866
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: December 1, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Jose Carlos Garcia-Garcia, George Franklin Gerberick, Stanley Leon Hazen, Xiaodong Gu
  • Methods for inhibiting conversion of carnitine to trimethylamine (TMA)
    Patent number: 10786479
    Abstract: The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 29, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Stanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, David Thomas Stanton, Thomas Alfred Inglin, Michael Reilly, Angela Jane Deutsch, Jodie Michele Reed, David Blair Cody
  • Methods for inhibiting conversion of choline to trimethylamine (TMA)
    Patent number: 10780072
    Abstract: The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 22, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Stanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, David Thomas Stanton, Thomas Alfred Inglin, Michael Reilly, Angela Jane Deutsch, Jodie Michele Reed, David Blair Cody
  • Methods for inhibiting conversion of choline to trimethylamine (TMA)
    Patent number: 10751301
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: August 25, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Jose Carlos Garcia-Garcia, George Franklin Gerberick, Michael Reilly, Stanley Leon Hazen, Xiaodong Gu
  • Methods for inhibiting conversion of choline to trimethylamine (TMA)
    Patent number: 10675256
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: June 9, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, Stanley Leon Hazen, Xiaodong Gu
  • METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20200138740
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising (2-hydroxyethyl) dimethylsulfonium with a counterion wherein the counterion is selected from chloride, bromide or iodide.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 7, 2020
    Inventors: Stanley Leon HAZEN, Jose Carlos GARCIA-GARCIA, Jodie Michelle REED, Lori Ann REINSALU, Vincent Peter Sica, Timothy R Baker
  • METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20200138887
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising an extract of Mikania.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 7, 2020
    Inventors: Stanley Leon HAZEN, Jose Carlos GARCIA-GARCIA, Jodie Michelle REED, Lori Ann REINSALU, Vincent Peter Sica, Timothy R Baker
  • METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20190099390
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):
    Type: Application
    Filed: October 2, 2018
    Publication date: April 4, 2019
    Inventors: Jose Carlos GARCIA-GARCIA, George Franklin GERBERICK, Stanley Leon HAZEN, Xiaodong GU
  • METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20190099384
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):
    Type: Application
    Filed: October 2, 2018
    Publication date: April 4, 2019
    Inventors: Jose Carlos GARCIA-GARCIA, George Franklin GERBERICK, Michael REILLY, Stanley Leon HAZEN, Xiaodong GU
  • METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20190099389
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):
    Type: Application
    Filed: October 2, 2018
    Publication date: April 4, 2019
    Inventors: Jose Carlos GARCIA-GARCIA, George Franklin GERBERICK, John August Wos, Stanley Leon HAZEN, Xiaodong GU
  • Compounds and methods for inhibiting production of trimethylamine
    Patent number: 10213407
    Abstract: The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I): The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: February 26, 2019
    Assignees: THE PROCTER & GAMBLE COMPANY, THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jose Carlos Garcia-Garcia, Stanley Leon Hazen, John August Wos
  • METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20180000754
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):
    Type: Application
    Filed: May 31, 2017
    Publication date: January 4, 2018
    Inventors: Stanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin GERBERICK, John August WOS, Xiaodong GU, Michael REILLY, Mark Robert SIVIK, Jodie Michelle REED, David Blair CODY
  • METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20170151208
    Abstract: The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.
    Type: Application
    Filed: December 1, 2016
    Publication date: June 1, 2017
    Inventors: Stanley Leon HAZEN, Jose Carlos GARCIA-GARCIA, George Franklin GERBERICK, John August WOS, David Thomas STANTON, Thomas Alfred INGLIN, Michael REILLY, Angela Jane DEUTSCH, Jodie Michele REED, David Blair CODY
  • METHODS FOR INHIBITING CONVERSION OF CARNITINE TO TRIMETHYLAMINE (TMA)
    Publication number: 20170151250
    Abstract: The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.
    Type: Application
    Filed: December 1, 2016
    Publication date: June 1, 2017
    Inventors: Stanley Leon HAZEN, Jose Carlos GARCIA-GARCIA, George Franklin GERBERICK, John August WOS, David Thomas STANTON, Thomas Alfred INGLIN, Michael REILLY, Angela Jane DEUTSCH, Jodie Michele REED, David Blair CODY
  • COMPOUNDS AND METHODS FOR INHIBITING PRODUCTION OF TRIMETHYLAMINE
    Publication number: 20170152222
    Abstract: The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I): The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.
    Type: Application
    Filed: December 1, 2016
    Publication date: June 1, 2017
    Inventors: Jose Carlos GARCIA-GARCIA, Stanley Leon HAZEN, John August WOS