Patents by Inventor Stefaan Julien Last

Stefaan Julien Last has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20200061059
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 27, 2020
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20200039931
    Abstract: Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 6, 2020
    Inventors: Koen VANDYCK, Geerwin Yvonne Paul HACHÉ, Stefaan Julien LAST, David Craig MCGOWAN, Geert ROMBOUTS, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES
    Publication number: 20200002342
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Application
    Filed: June 14, 2019
    Publication date: January 2, 2020
    Inventors: David Craig MC GOWAN, Serge Maria Aloysius PIETERS, Stefaan Julien LAST, Werner EMBRECHTS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON
  • HETEROCYCLIC SUBSTITUTED 2-AMINO QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20190330160
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: April 8, 2019
    Publication date: October 31, 2019
    Inventors: Stefaan Julien Last, David Craig Mc Gowan, Werner Embrechts, Serge Maria Aloysius Pieters, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES
    Publication number: 20190330217
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 31, 2019
    Inventors: David Craig MC GOWAN, Stefaan Julien LAST, Serge Maria Aloysius PIETERS, Werner EMBRECHTS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON
  • Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 10457638
    Abstract: Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: October 29, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Stefaan Julien Last, David Craig McGowan, Geert Rombouts, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson
  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 10420767
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: September 24, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 10398677
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: September 3, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Stefaan Julien Last, Pierre Jean-Marie Bernard Raboisson
  • Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
    Patent number: 10385054
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: August 20, 2019
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: David Craig McGowan, Serge Maria Aloysius Pieters, Stefaan Julien Last, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 10272085
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: April 30, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
    Patent number: 10259814
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: April 16, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: David Craig McGowan, Stefaan Julien Last, Serge Maria Aloysius Pieters, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections
    Patent number: 10253003
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: April 9, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: Stefaan Julien Last, David Craig McGowan, Werner Embrechts, Serge Maria Aloysius Pieters, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 10160743
    Abstract: Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: December 25, 2018
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Stefaan Julien Last, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson
  • Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 10125094
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, salts, hydrates and solvates thereof, wherein R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: November 13, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Stefaan Julien Last, Pierre Jean-Marie Bernard Raboisson
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20180207155
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 26, 2018
    Inventors: David McGOWAN, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • N-PHENYL-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20180153857
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: February 1, 2018
    Publication date: June 7, 2018
    Inventors: Koen VANDYCK, Geerwin Yvonne Paul HACHÉ, Stefaan Julien LAST, Pierre Jean-Marie Bernard RABOISSON
  • SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20180141905
    Abstract: Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: January 19, 2018
    Publication date: May 24, 2018
    Inventors: Koen VANDYCK, Geerwin Yvonne Paul HACHÉ, Stefaan Julien LAST, David Craig MCGOWAN, Geert ROMBOUTS, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20180127361
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: August 18, 2017
    Publication date: May 10, 2018
    Inventors: Koen VANDYCK, Stefaan Julien LAST, Geert ROMBOUTS, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 9895349
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: February 20, 2018
    Assignee: Janssen Sciences Ireland US
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Stefaan Julien Last, Pierre Jean-Marie Bernard Raboisson
  • Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 9884818
    Abstract: Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing compounds of Formula (ID), pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: February 6, 2018
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Stefaan Julien Last, David Craig Mc Gowan, Geert Rombouts, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson