Patents by Inventor Stefan HEKE

Stefan HEKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210290534
    Abstract: A method for the production of freeze-dried pellets comprising an anti-FXIa antibody comprises the steps of: a) freezing droplets of a solution comprising an anti-FXIa antibody to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising an anti-FXIa antibody into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.
    Type: Application
    Filed: July 5, 2019
    Publication date: September 23, 2021
    Applicant: Bayer Aktiengesellschaft
    Inventors: Stefan Christian SCHNEID, Stefan HEKE, Matthias PLITZKO
  • Publication number: 20210292434
    Abstract: The present invention refers to novel liquid pharmaceutical high-concentration formulations particularly suitable for subcutaneous administration comprising human antibodies against coagulation factor FXIa as active ingredient, especially those described in WO2013167669, which are stable as liquid formulations over a long period. The invention also refers to lyophilizates of the specified liquid formulation with reduced reconstitution time and also to the use of these formulations in the therapy and prophylaxis of thrombotic or thromboembolic disorder.
    Type: Application
    Filed: July 5, 2019
    Publication date: September 23, 2021
    Applicant: Bayer Aktiengesellschaft
    Inventors: Niklas GOMBERT, Marieke VEURINK, Alexander KLAK, Stefan Christian SCHNEID, Stefan HEKE, Matthias PLITZKO