Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

Abstract: Disclosed herein is a method for the transcutaneous determination of organ function in a subject. The method includes administering a fluorescent indicator substance to the subject, determining a first and a second concentration-time curve of the fluorescent indicator in a body fluid of the patient and fitting the concentration-time curves to a four compartment kinetic model.

Abstract: The invention relates to a connection arrangement for connecting a pipeline, in particular a metallic pipeline, the arrangement having a screw connection body having a pipe holder for the pipeline, a union nut that can be screwed onto the screw connection body, as well as a cutting ring disposed between the screw connection body and the union nut, wherein the cutting ring has an outer cone that interacts with an inner cone of the pipe holder of the screw connection body in such a manner that it is deformed radially inward in some regions when the union nut is tightened, and cuts into the material of the pipeline with at least one cutting edge, with a notching effect, with shape fit, and wherein the cutting ring has an essentially radial contact surface, subsequent to the outer cone, which surface limits tightening against a face surface of the screw connection body, and wherein an elastomer circumferential seal is disposed in a ring groove in the region of the outer cone of the cutting ring, for contact insid

Abstract: Preliminary seal, comprising an essentially circular disc (1) of an electrically conductive material (2) permeable to air and a carrier body (3), wherein the disc (1) is configured as a separately produced individual part—in relation to the carrier body (3)—is joined to the carrier body (3).

Abstract: A device for fixing components, particularly pipes or tubes, includes two fixing parts with recesses, which can be connected to each other, the parts forming a bushing in the mounted state, the inner contour thereof being designed to receive a pipe or a tube, at least one sacrificial element being arranged for minimizing corrosion, particularly crevice corrosion, in the event of a respectively received component being increasingly consumed with the onset of corrosion and reduction of the service life of the fixation. At least one fixing part includes at least one recess which opens up into the inner contour of the bushing and in which at least one sacrificial element is movably arranged, the sacrificial element being pre-stressed in the direction of the bushing by a spring element.

Abstract: The invention relates to an acceleration sensor (100) having a sensor material (120) which is mounted by means of spring elements (130) so as to be movable along a movement axis (x) over a substrate (110), first trim electrodes (140) which are connected to the sensor material (120), and second trim electrodes (150) which are connected to the substrate (110) and are associated with the first trim electrodes (140). When the sensor material is deflected along the movement axis, a spring force acting on the sensor material (120) is generated by the spring elements (130), and when the sensor material (120) is deflected, an electrostatic force acting on the sensor material (120), which counteracts the spring force, is generated by application of an electrical trim voltage between the first trim electrodes (140) and the second trim elements (150).

Abstract: A device for reduced-noise fastening of pipes or hoses includes two fastening parts which are connectable to one another and which have recesses which, in the assembled state, form a leadthrough in which there is arranged a vibration-damping ring-shaped insert, the internal contour of which is designed for receiving a pipe or hose. The insert is formed by a hollow cylindrical main body, on the outer shell surface of which there are arranged, spaced apart from one another, two encircling radially outwardly projecting webs, wherein, in the leadthrough of the fastening parts, there is arranged a radially encircling central web which engages into a groove formed between the webs of the insert.

Abstract: The invention relates to an acceleration sensor (100) having a sensor material (120) which is mounted by means of spring elements (130) so as to be movable along a movement axis (x) over a substrate (110), first trim electrodes (140) which are connected to the sensor material (120), and second trim electrodes (150) which are connected to the substrate (110) and are associated with the first trim electrodes (140). When the sensor material is deflected along the movement axis, a spring force acting on the sensor material (120) is generated by the spring elements (130), and when the sensor material (120) is deflected, au electrostatic three acting on the sensor material (120), which counteracts the spring force, is generated by application of an electrical trim voltage between the first trim electrodes (140) and the second trim elements (150).

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.

Abstract: A device for reduced-noise fastening of pipes or hoses includes two fastening parts which are connectable to one another and which have recesses which, in the assembled state, form a leadthrough in which there is arranged a vibration-damping ring-shaped insert, the internal contour of which is designed for receiving a pipe or hose. The insert is formed by a hollow cylindrical main body, on the outer shell surface of which there are arranged, spaced apart from one another, two encircling radially outwardly projecting webs, wherein, in the leadthrough of the fastening parts, there is arranged a radially encircling central web which engages into a groove formed between the webs of the insert.

Abstract: Preliminary seal, comprising an essentially circular disc (1) of an electrically conductive material (2) permeable to air and a carrier body (3), wherein the disc (1) is configured as a separately produced individual part—in relation to the carrier body (3)—is joined to the carrier body (3).

Abstract: The invention relates to a process for the preparation of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide by acylating the oxime oxygen of the compound of formula (VIII), in the presence of a solvent and an acylating agent of formula (XI) R1C(X)—CI (XI); wherein X is oxygen or sulfur; R1 is chloro if X is oxygen or sulfur; or R1 is C1-C6alkoxy, CH3—C(?CH2)—O—, phenoxy or trichloromethoxy if X is oxygen; and a) if R1 is chloro and the compound of formula (XI) was added to the compound of formula (VIII); reacting the so obtained product of formula (XIIa) wherein X is oxygen or sulfur; with the compound of formula (IX) b) if R1 is chloro and the compound of formula (VIII) was added to the compound of formula (XI); or R1 is C1-C6alkoxy, CH3—C(?CH2)—O—, phenoxy or trichloromethoxy if X is oxygen; reacting the so obtained product of formula (XII) wherein X is oxygen or sulfur; R1 is chloro if X is oxygen or sulfur; or R1 is C1-C6alko

Abstract: The invention relates to a process for the preparation of 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide by acylating the oxime oxygen of the compound of formula (VIII), in the presence of a solvent and an acylating agent of formula (XI) R 1C(X)—CI (XI); wherein X is oxygen or sulfur; R1 is chloro if X is oxygen or sulfur; or R1 is C1-C6alkoxy, CH3—C(?CH2)-0-, phenoxy or trichloromethoxy if X is oxygen; and a) if R1 is chloro and the compound of formula (XI) was added to the compound of formula (VIII); reacting the so obtained product of formula (XIIa) wherein X is oxygen or sulfur; with the compound of formula (IX) b) if R1 is chloro and the compound of formula (VIII) was added to the compound of formula (XI); or R1 is C1-C6alkoxy, CH3—C(?CH2)-0-, phenoxy or trichloromethoxy if X is oxygen; reacting the so obtained product of formula (XII) wherein X is oxygen or sulfur; R1 is chloro if X is oxygen or sulfur; or R1 is C1-C6al