Patents by Inventor Stefan Schillberg

Stefan Schillberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10519206
    Abstract: The technology provided herein generally relates relates to genetically modified higher plants, for example C3 and C4 plants, and subsequent generations thereof, comprising stable and/or transient expression of at least one gene-product (e.g. mRNA or protein) of the “Chlamydomonas reinhardtii CO2 concentrating mechanism” (CCM), wherein the expression takes place in the intermembrane space and/or one or more subcellular compartments of the chloroplasts of the higher plant, and wherein this expression increases one or more of the characteristics selected from the group of photosynthetic rate, photosynthetic carbon fixation, chlorophyll level and/or biomass of the genetically modified higher plant (T0) and/or of the T1 and/or T2 generation or any subsequent plant generation of said genetically modified higher plant.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: December 31, 2019
    Assignee: Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V.
    Inventors: Greta Noelke, Stefan Schillberg, Fritz Kreutzaler, Mirna Barsoum, Rainer Fischer
  • Publication number: 20190380330
    Abstract: The technology provided herein relates to novel methods and systems for cell-free protein synthesis, in particular to cell-free protein synthesis systems suitable for protein synthesis before and after freezing for a short- or long-term storage, wherein said system comprises a cryoprotectant.
    Type: Application
    Filed: January 25, 2018
    Publication date: December 19, 2019
    Inventors: Matthias Buntru, Simon Vogel, Stefan Schillberg
  • Publication number: 20190376068
    Abstract: The technology provided herein relates to novel promoter constructs, method and systems for an increase in the target protein yield and/or allowing the use of lower template concentration in the cell-free protein synthesis systems.
    Type: Application
    Filed: January 25, 2018
    Publication date: December 12, 2019
    Inventors: Matthias Buntru, Simon Vogel, Stefan Schillberg
  • Patent number: 10480001
    Abstract: The invention provides a method for the generation of a monoclonal plant cell line from a heterologous population of plant cells, comprising the following steps: (a) provision of a heterologous population of plant cells; (b) preparation of protoplasts from said heterologous population of plant cells; (c) separation of single protoplasts by subjecting the preparation of protoplasts to flow cytometric sorting; (d) regeneration of a separated single transformed protoplast until the formation of a microcolony by co-cultivation in the presence of feeder cell material; (e) removal of the microcolony from the feeder cell material and cultivation of the microcolony until the formation of a monoclonal plant cell line.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: November 19, 2019
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Janina Kirchhoff, Stefan Schillberg, Andreas Schiermeyer, Helga Schinkel, Rainer Fischer
  • Publication number: 20190241981
    Abstract: The technology provided herein relates to novel methods for screening/detecting of plants, in particular by a multiplex PCR-based combined with a next-generation sequencing approach to analyze a plurality of characteristics (e.g. target sequences) of an individual plant in parallel.
    Type: Application
    Filed: January 25, 2017
    Publication date: August 8, 2019
    Inventors: Florian Schroper, Leonie Fritsch, Stefan Schillberg
  • Publication number: 20190202872
    Abstract: A recombinant dietary protein is provided that is free of phenylalanine and is a dietary protein with a high biological value. Further provided are a vector encoding said dietary protein, a microorganisms expressing said protein, a method for the production of said protein, and a dietary composition comprising said protein that in an embodiment is for use as a medicament and/or food for special medical purposes in patients with accumulations of phenylalanine in the body.
    Type: Application
    Filed: August 30, 2017
    Publication date: July 4, 2019
    Inventors: Bernhard HOFFMANN, Yvonne MÜCKE, Stefan RASCHE, Natalia JABLONKA, Stefan SCHILLBERG
  • Publication number: 20180245087
    Abstract: This disclosure concerns the systems, methods, and kits for the in vitro synthesis of biological macromolecules in a reaction utilizing cell lysates containing plastids, mitochondria and/or chloroplasts, wherein creatine phosphate and creatine kinase are not added to the reaction to provide artificial energy regeneration.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 30, 2018
    Inventors: Krishna Madduri, Janna Armstrong, Audrey Etter, Matthias Buntru, Simon Vogel, Stefan Schillberg, Rainer Fischer
  • Publication number: 20180105832
    Abstract: The technology provided herein relates to novel methods and compounds for a multi-species pathogen infection control. In particular, the present disclosure pertains to methods of inhibiting the growth of a target pathogen expressing the cysteine-rich secreted protein (CSP), whereby the method comprises contacting said target pathogen with an inhibitor against said CSP, wherein said inhibitor inhibits the CSP expression and/or binds to a protein product of a gene coding CSP. Nucleic acid molecules encoding said inhibitors, vectors and host cells containing the nucleic acids and methods for preparation and producing such inhibitors are also disclosed, as well as the use of said CSP-inhibitors for the control/treatment of diseases associated with a microbial pathogen expressing CSP.
    Type: Application
    Filed: April 13, 2015
    Publication date: April 19, 2018
    Inventors: Greta Noelke, Stefan Schillberg, Max Schubert
  • Publication number: 20170283473
    Abstract: The technology provided herein generally relates relates to genetically modified higher plants, for example C3 and C4 plants, and subsequent generations thereof, comprising stable and/or transient expression of at least one gene-product (e.g. mRNA or protein) of the “Chlamydomonas reinhardtii CO2 concentrating mechanism” (CCM), wherein the expression takes place in the intermembrane space and/or one or more subcellular compartments of the chloroplasts of the higher plant, and wherein this expression increases one or more of the characteristics selected from the group of photosynthetic rate, photosynthetic carbon fixation, chlorophyll level and/or biomass of the genetically modified higher plant (T0) and/or of the T1 and/or T2 generation or any subsequent plant generation of said genetically modified higher plant.
    Type: Application
    Filed: November 26, 2015
    Publication date: October 5, 2017
    Inventors: Greta Noelke, Stefan Schillberg, Fritz Kreutzaler, Mirna Barsoum, Rainer Fischer
  • Patent number: 9371538
    Abstract: The invention relates to a method for stimulating the growth of the plants and/or improving the biomass production and/or increasing the carbon fixation by the plant comprising introducing into a plant cell, plant tissue or plant one or more nucleic acids, wherein the introduction of the nucleic acid(s) results inside the chloroplast of a de novo expression of one or more polypeptides having the enzymatic activity of a glycolate dehydrogenase made up from translationally fused subunits of bacterial multi-subunit glycolate dehydrogenase enzymes.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: June 21, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Fritz Kreuzaler, Greta Noelke, Christoph Peterhaensel, Stefan Schillberg
  • Publication number: 20140053300
    Abstract: The invention provides a method for the generation of a monoclonal plant cell line from a heterologous population of plant cells, comprising the following steps: (a) provision of a heterologous population of plant cells; (b) preparation of protoplasts from said heterologous population of plant cells; (c) separation of single protoplasts by subjecting the preparation of protoplasts to flow cytometric sorting; (d) regeneration of a separated single transformed protoplast until the formation of a microcolony by co-cultivation in the presence of feeder cell material; (e) removal of the microcolony from the feeder cell material and cultivation of the microcolony until the formation of a monoclonal plant cell line.
    Type: Application
    Filed: June 7, 2011
    Publication date: February 20, 2014
    Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Janina Kirchhoff, Stefan Schillberg, Andreas Schiermeyer, Helga Schinkel, Rainer Fischer
  • Publication number: 20120317683
    Abstract: The invention relates to a method for stimulating the growth of the plants and/or improving the biomass production and/or increasing the carbon fixation by the plant comprising introducing into a plant cell, plant tissue or plant one or more nucleic acids, wherein the introduction of the nucleic acid(s) results inside the chloroplast of a de novo expression of one or more polypeptides having the enzymatic activity of a glycolate dehydrogenase made up from translationally fused subunits of bacterial multi-subunit glycolate dehydrogenase enzymes.
    Type: Application
    Filed: February 3, 2011
    Publication date: December 13, 2012
    Inventors: Fritz Kreuzaler, Greta Noelke, Christoph Peterhaensel, Stefan Schillberg
  • Publication number: 20120042416
    Abstract: The present invention relates to fusion proteins comprising anti-Oomycotic proteins or peptides linked to an antibody or fragment thereof specifically recognising an epitope of an Oomycota. The invention is also directed to polynucleotides coding for the fusion proteins. The embodiments of the present invention are particularly useful for the protection of plants against Oomycota. The invention therefore comprises transgenic plants expressing the fusion proteins of the present invention.
    Type: Application
    Filed: August 5, 2010
    Publication date: February 16, 2012
    Applicant: Fraunhofer-Gesellschaft zur Forderung der angewandten e.V.
    Inventors: Sylvia Schleker, Dieter Peschen, Rainer Fischer, Stefan Schillberg
  • Publication number: 20110263826
    Abstract: The present invention provides antibodies which bind selectively to hair of animals and an antibody based drug delivery system in which a particular formulation can be directed to animal hair.
    Type: Application
    Filed: October 29, 2008
    Publication date: October 27, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Stefan Hofmann, Hans-Juergen Hamann, Rainer Fischer, Stefan Schillberg, Simon Oliver Vogel, Helga Schinkel
  • Patent number: 7531522
    Abstract: A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the vectors of the composition of the invention into the genome of a plant, plant cell or plant cell tissue and a transgenic plant cell comprising stably integrated into the genome a polynucleotide or vector of the invention or the vectors of the composition of the invention.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: May 12, 2009
    Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.
    Inventors: Dieter Peschen, Rainer Fischer, Stefan Schillberg, Yu-Cai Liao, Simone Dorfmüller
  • Publication number: 20050244901
    Abstract: A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the vectors of the composition of the invention into the genome of a plant, plant cell or plant cell tissue and a transgenic plant cell comprising stably integrated into the genome a polynucleotide or vector of the invention or the vectors of the composition of the invention.
    Type: Application
    Filed: April 14, 2003
    Publication date: November 3, 2005
    Inventors: Dieter Peschen, Rainer Fischer, Stefan Schillberg, Yu-Cai Liao, Simone Dorfmuller
  • Publication number: 20050037420
    Abstract: This invention relates to immunoglobulin molecules comprising light chain (VL) chimeric variable domains, heavy chain (VH) chimeric variable domains, e.g., scFv antibodies that are expressed at high levels within a host cell, preferably within particular cellular compartments such as, e.g., cytosol or apoplast. The VL, VH and scFv antibody molecules comprise framework scaffolds of particularly preferred framework regions. This invention also relates to nucleic acid molecules encoding the immunoglobulin molecules of this invention, vectors expressing the immunoglobulin molecules, hosts transformed with the nucleic acid molecules and vectors, and methods of using the immunoglobulin molecules. Also described are immunoglobulin libraries as well as host cells, including transgenic plants, expressing the VL, VH or scFv antibody molecules of this invention.
    Type: Application
    Filed: September 13, 2002
    Publication date: February 17, 2005
    Inventors: Mei-Yun Zhang, Stefan Schillberg, Sabine Zimmermann, Stefano Fiore, Neil Emans, Rainer Fischer
  • Patent number: 6825325
    Abstract: The present invention is drawn to a fusion protein containing at least one binding domain that specifically recognizes an eptitope of a plant pathogen and at least one additional domain made from a protein or peptide sequence which is toxic to the pathogen or detrimental the replication, transmission or life cycle of the pathogen. The present invention is further drawn to a pathogenocide made from the binding domain, a cellular targeting sequence and/or membrane localization sequence that leads to membrane anchoring. The present invention is further drawn to nucleotide sequences encoding fusion proteins and pathogenocides and to vectors containing the nucleotide sequences; as well as methods of making the fusion proteins and pathogencides and methods of making pathogen resistant plants, plant cells, or plant tissues with the fusion proteins and pathogenocides.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: November 30, 2004
    Assignee: Fraunhofer Gesellschaft zur Forderung der angewandten Forschung e.V.
    Inventors: Rainer Fischer, Stefan Schillberg, Jörg Nähring, Markus Sack, Michael Monecke, Yu-Cai Liao, Holger Spiegel, Sabine Zimmerman, Neil Emans
  • Publication number: 20030051275
    Abstract: Rice, wheat and other monocotyledonous plants are transformed with expression cassettes for production of mammalian polypeptides, such as antibodies. Endoplasmic reticulum (ER) retention signals, 5′ untranslated regions and leader peptides are employed in various combinations to provide high expression yield. Multi-chain complexes such as four-chain secretory antibodies are produced by expression of component polypeptides from separate vectors all introduced into the same cell by transformation.
    Type: Application
    Filed: April 23, 2002
    Publication date: March 13, 2003
    Inventors: Paul Christou, Eva Stoger, Rainer Fischer, Carmen Martin-Vaquero, Stefan Schillberg, Julian K-C Ma
  • Publication number: 20020078472
    Abstract: Rice, wheat and other monocotyledonous plants are transformed with expression cassettes for production of mammalian polypeptides, such as antibodies. Endoplasmic reticulum (ER) retention signals, 5′untranslated regions and leader peptides are employed in various combinations to provide high expression yield. Multi-chain complexes such as four-chain secretory antibodies are produced by expression of component polypeptides from separate vectors all introduced into the same cell by transformation.
    Type: Application
    Filed: June 15, 1999
    Publication date: June 20, 2002
    Inventors: PAUL CHRISTOU, EVA STOGER, RAINER FISCHER, CARMEN MARTIN-VAQUERO, STEFAN SCHILLBERG, JULIAN K-C MA