Abstract: A vehicle braking system includes an assistance device, having a vacuum pump driven by an engine for communicating vacuum to a chamber of the assistance device. A control valve is interposed along a fluid line between the pump and the chamber. The control valve is in its first operative condition, where the inlet side of the vacuum pump communicates with the chamber, when the pressure within the chamber is above a predetermined value; and is in its second operative condition, where the inlet side of the vacuum pump communicates with the atmosphere, when pressure within the chamber is below a predetermined value. In this second condition the pump intakes air from and feeds air into the atmosphere, thereby reducing the energy consumption by the engine required for driving the pump during stages where, within the chamber there is a vacuum sufficient for the regular operation of the braking system.

Abstract: Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:

Abstract: Described herein are polymorphic forms of 1,6-dibromo-1,6-dideoxy-dulcitol (dibromo dulcitol or DBD), which is a known antitumor agent. Also described are methods of making these new crystalline polymorphic forms as well as methods of using these polymorphic forms to treat cancer.

Abstract: Described herein are polymorphic forms of 1,6-dibromo-1,6-dideoxy-dulcitol (dibromo dulcitol or DBD), which is a known antitumor agent. Also described are methods of making these new crystalline polymorphic forms as well as methods of using these polymorphic forms to treat cancer.

Abstract: A vehicle braking system includes a controller that receives signals from sensors associated with vehicle disc brakes, which allow detection of a parameter indicative of a degree of noise generated from each disc brake. When noise generation is detected, the controller activates a noise attenuation function of a first type if the vehicle is braking, and of a second type if the vehicle is not braking. The first type involves reducing actuating pressure of a fluid actuator associated with the disc brake for which noise generation is detected. The second type involves temporarily activating, while the vehicle is running and not braking, the fluid actuator associated with the disc brake which is generating noise. The controller also receives signals indicative of vehicle operating parameters which allow conditions to be defined in which priority is given to vehicle safety, and in which the noise attenuation function is excluded.

Abstract: Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:

Abstract: The present invention relates to a novel crystalline hemihydrate polymorph of neridronic acid sodium salt, and a novel process for the preparation thereof comprising the steps of: 1) dissolving solid sodium neridronate in any crystalline form in water, at a temperature in the range from 70 to 90° C., to obtain an aqueous solution of sodium neridronate; 2) adding a solvent selected from the group consisting in ethanol, 1-propanol, and 2-propanol to the aqueous solution obtained from step (1), so that the final water:solvent volume ratio is in the range from 1:0.5 to 1:1, thus obtaining a suspension; 3) placing the suspension obtained from step (2) under mechanical stirring, at a temperature in the range from 60 to 95° C.; 4) recovering the crystalline hemihydrate form F of sodium neridronate formed in the previous step (3).

Abstract: The present invention provides novel crystalline forms of 4-[3-Chloro-4-(N?-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate, as well as methods for their preparation.

Abstract: A suspension device of a motor-vehicle wheel includes a support member of the wheel connected to a structure of the motor-vehicle by one or more suspension members and a brake disc connected in rotation with the motor-vehicle wheel. The device also includes a brake disc cover rigidly connected to the support member and at least partially surrounding the brake disc. The brake disc cover is formed in a single piece with said support member of the motor-vehicle wheel.

Abstract: An automotive active brake noise damping system to actively damp braking noise perceivable in the passenger compartment of a motor vehicle comprising a braking system comprising a plurality of braking assemblies associated with wheels of the motor vehicle. The automotive active brake noise damping system comprises a sensory system to sense quantities that allow braking noise perceived in the passenger compartment of the motor vehicle and generated by the braking assemblies during braking to be estimated, an audio system to diffuse sounds in the passenger compartment of the motor vehicle, and an electronic control unit connected to the sensory system and the audio system, and programmed to control the audio system based on the quantities sensed by the sensor system to actively damp the braking noise perceived in the passenger compartment of the motor vehicle.

Abstract: Described herein are polymorphic forms of 1,6-dibromo-1,6-dideoxy-dulcitol (dibromo dulcitol or DBD), which is a known antitumor agent. Also described are methods of making these new crystalline polymorphic forms as well as methods of using these polymorphic forms to treat cancer.

Abstract: Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:

Abstract: An automotive active brake noise damping system to actively damp braking noise perceivable in the passenger compartment of a motor vehicle comprising a braking system comprising a plurality of braking assemblies associated with wheels of the motor vehicle. The automotive active brake noise damping system comprises a sensory system to sense quantities that allow braking noise perceived in the passenger compartment of the motor vehicle and generated by the braking assemblies during braking to be estimated, an audio system to diffuse sounds in the passenger compartment of the motor vehicle, and an electronic control unit connected to the sensory system and the audio system, and programmed to control the audio system based on the quantities sensed by the sensor system to actively damp the braking noise perceived in the passenger compartment of the motor vehicle.

Abstract: A brake disc for motor-vehicle disc brakes, includes a body with a hub and two opposite annular planar faces, wherein at least one of these faces is formed with one or more lines defining a surface irregularity, in the form of grooves or ribs, which extend between a radially inner edge and a radially outer edge of the respective face, so as to substantially cover the entire radial extension of the face. A height of the surface irregularity along said lines is less than 0.30 mm, so that during use, the lines defining the surface irregularity disappear, due to wear of the respective face, after an initial fraction of the life of the brake disc. During this initial stage, the lines defining the surface irregularity reduce the time necessary to obtain a bedding of the disc brake with respect to a case of a brake disc devoid of the lines.

Abstract: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

Abstract: A ventilated brake disk for a motor vehicle has a rotor provided with two disks having respective inner faces, which are axially spaced apart and are joined to each other through a plurality of pins; the radially outermost end areas of the two faces axially define between them an annular passage, which houses the wavy intermediate portion of a wire damping element; this intermediate portion is elastically deformed in a direction parallel to the axis of the rotor so as to be forced against the disks; at its opposite ends, the wire damping element ends with two fastening portions which are radially inwardly bent with respect to the intermediate portion and are hooked to respective pins.

Abstract: The present invention relates to novel crystalline forms of vortioxetine hydrobromide, in particular three crystalline forms, a process for their preparation, a pharmaceutical composition containing said novel crystalline forms, and a process for the purification of vortioxetine or a salt thereof, comprising the formation of one or more of the novel crystalline forms of vortioxetine hydrobromide described herein.

Abstract: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

Abstract: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

Abstract: A ventilated brake disk for a motor vehicle has a rotor provided with two disks having respective inner faces, which are axially spaced apart and are joined to each other through a plurality of pins; the radially outermost end areas of the two faces axially define between them an annular passage, which houses the wavy intermediate portion of a wire damping element; this intermediate portion is elastically deformed in a direction parallel to the axis of the rotor so as to be forced against the disks; at its opposite ends, the wire damping element ends with two fastening portions which are radially inwardly bent with respect to the intermediate portion and are hooked to respective pins.