Abstract: Cation exchange membranes and materials including silica-based ceramics, and associated methods, are provided. In some aspects, cation exchange membranes that include a silica-based ceramic that forms a coating on and/or within a porous support membrane are described. The cation exchange membranes and materials may have certain structural or chemical attributes (e.g., pore size/distribution, chemical functionalization) that, alone or in combination, can result in advantageous performance characteristics in any of a variety of applications for which selective transport of positively charged ions through membranes/materials is desired. In some embodiments, the silica-based ceramic contains relatively small pores (e.g., substantially spherical nanopores) that may contribute to some such advantageous properties. In some embodiments, the cation exchange membrane or material includes sulfonate and/or sulfonic acid groups covalently bound to the silica-based ceramic.

Abstract: A method is provided for maintaining resin in a system including a main feed tank and at least one vat, each of the at least one vats associated with a 3-D printing machine. The method includes the steps of: transferring resin from the main feed tank to the at least one vat; operating the associated 3-D printing machine in a build cycle; returning the resin from the at least one vat to the main feed tank; and repeating in a cycle the steps of transferring the resin, operating the 3-D printing machine, and returning the resin.

Abstract: The present invention relates to antibodies that bind to human CD137 and display agonist activity, and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.

Abstract: The present invention relates to antibodies that bind to human CD137 and display agonist activity, and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.

Abstract: Mammalian cell lines with reduced expression and/or activity of lipases/esterases, and methods of producing the same are provided. Also provided are compositions comprising polysorbate and recombinant proteins produced in said mammalian cells which have improved polysorbate stability.

Abstract: The present disclosure is directed to a method of altering chemical properties of an in-process resin used with a 3D printing apparatus. The method includes monitoring the in-process resin using an imaging spectrometer, comparing the in-process resin and a model using one or more spectrums from the imaging spectrometer, and diluting the in-process resin with a diluting resin.

Abstract: Cation exchange membranes and materials including silica-based ceramics, and associated methods, are provided. In some aspects, cation exchange membranes that include a silica-based ceramic that forms a coating on and/or within a porous support membrane are described. The cation exchange membranes and materials may have certain structural or chemical attributes (e.g., pore size/distribution, chemical functionalization) that, alone or in combination, can result in advantageous performance characteristics in any of a variety of applications for which selective transport of positively charged ions through membranes/materials is desired. In some embodiments, the silica-based ceramic contains relatively small pores (e.g., substantially spherical nanopores) that may contribute to some such advantageous properties. In some embodiments, the cation exchange membrane or material includes sulfonate and/or sulfonic acid groups covalently bound to the silica-based ceramic.

Abstract: The present disclosure generally relates to additive manufacturing of an object using both a digital light processing (DLP) projector and a focused energy source to irradiate a photopolymerizable material, and apparatuses and methods for the same. The DLP projector irradiates and cures an outer perimeter of the object, and the focused energy source irradiates and cures an inner region of the object. In a preferred embodiment, irradiation by both the DLP projector and the focused energy source occur from underneath a tank holding the photopolymerizable material and through a transparent window.

Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.

Abstract: Cation exchange membranes and materials including silica-based ceramics, and associated methods, are provided. In some aspects, cation exchange membranes that include a silica-based ceramic that forms a coating on and/or within a porous support membrane are described. The cation exchange membranes and materials may have certain structural or chemical attributes (e.g., pore size/distribution, chemical functionalization) that, alone or in combination, can result in advantageous performance characteristics in any of a variety of applications for which selective transport of positively charged ions through membranes/materials is desired. In some embodiments, the silica-based ceramic contains relatively small pores (e.g., substantially spherical nanopores) that may contribute to some such advantageous properties. In some embodiments, the cation exchange membrane or material includes sulfonate and/or sulfonic acid groups covalently bound to the silica-based ceramic.

Abstract: The present invention relates to antibodies that bind to human CD137 and display agonist activity, and is useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.

Abstract: Cation exchange membranes and materials including silica-based ceramics, and associated methods, are provided. In some aspects, cation exchange membranes that include a silica-based ceramic that forms a coating on and/or within a porous support membrane are described. The cation exchange membranes and materials may have certain structural or chemical attributes (e.g., pore size/distribution, chemical functionalization) that, alone or in combination, can result in advantageous performance characteristics in any of a variety of applications for which selective transport of positively charged ions through membranes/materials is desired. In some embodiments, the silica-based ceramic contains relatively small pores (e.g., substantially spherical nanopores) that may contribute to some such advantageous properties. In some embodiments, the cation exchange membrane or material includes sulfonate and/or sulfonic acid groups covalently bound to the silica-based ceramic.

Abstract: Anion exchange membranes and materials including silica-based ceramics, and associated methods, are provided. In some aspects, anion exchange membranes that include a silica-based ceramic that forms a coating on and/or within a porous support membrane are described. The anion exchange membranes and materials may have certain structural or chemical attributes (e.g., pore size/distribution, chemical functionalization) that, alone or in combination, can result in advantageous performance characteristics in any of a variety of applications for which selective transport of positively charged ions through membranes/materials is desired. In some embodiments, the silica-based ceramic contains relatively small pores (e.g., substantially spherical nanopores) that may contribute to some such advantageous properties. In some embodiments, the anion exchange membrane or material includes quaternary ammonium groups covalently bound to the silica-based ceramic.

Abstract: The present invention relates to antibodies that bind to human CD137 and display agonist activity, and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.

Abstract: According to one embodiment, a method for thermally treating glass articles may include holding a glass article at a treatment temperature equal to an annealing temperature of the glass article ±15° C. for a holding time greater than or equal to 5 minutes. Thereafter, the glass article may be cooled from the treatment temperature through a strain point of the glass article at a first cooling rate CR1 less than 0° C./min and greater than ?20° C./min such that a density of the glass article is greater than or equal to 0.003 g/cc after cooling. The glass article is subsequently cooled from below the strain point at a second cooling rate CR2, wherein |CR2|>|CR1|.

Abstract: The present invention relates to antibodies that bind to human CD137 and display agonist activity, and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.

Abstract: A slurry composition includes, by volume, a ceramic composition in an amount of from about 60 to about 75 percent and a binder in an amount of from about 25 to about 40 percent, plus a platinum group metal catalyst and a dopant. The ceramic composition includes, by volume of the ceramic composition, fine fused silica particles having a particle size d50 of from about 4 ?m to about 7 ?m, in an amount of from about 7 to about 40 percent; coarse fused silica particles having a d50 of from about 25 ?m to about 33 ?m, in an amount of from about 29 to about 60 percent; inert filler particles having a d50 of from about 5 ?m to about 25 ?m, in an amount of from about 8 to about 40 percent; and fumed silica particles, in an amount of up to about 15 percent.

Abstract: A method is provided for maintaining resin in a system including a main feed tank and at least one vat, each of the at least one vats associated with a 3-D printing machine. The method includes the steps of: transferring resin from the main feed tank to the at least one vat; operating the associated 3-D printing machine in a build cycle; returning the resin from the at least one vat to the main feed tank; and repeating in a cycle the steps of transferring the resin, operating the 3-D printing machine, and returning the resin.

Abstract: The present disclosure is directed to a method of altering chemical properties of an in-process resin used with a 3D printing apparatus. The method includes monitoring the in-process resin using an imaging spectrometer, comparing the in-process resin and a model using one or more spectrums from the imaging spectrometer, and diluting the in-process resin with a diluting resin.

Abstract: A method is provided for maintaining resin in a system including a main feed tank and at least one vat, each of the at least one vats associated with a 3-D printing machine. The method includes the steps of: transferring resin from the main feed tank to the at least one vat; operating the associated 3-D printing machine in a build cycle; returning the resin from the at least one vat to the main feed tank; and repeating in a cycle the steps of transferring the resin, operating the 3-D printing machine, and returning the resin.