Publication number: 20110223102
Abstract: A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is 11C, 18F, 64Cu, 124I, 99Tc, 111In or GdIII and its method of use for diagnosing, imaging and/or treating hyperproliferative tissue such as tumors. Preferably the photosensitizer is a tumor avid tetrapyrollic photosensitizer, e.g. a porphyrin, chlorin or bacteriochlorin, e.g. pheophorbides and pyropheophorbides. Such conjugates have extreme tumor avidity and can be used to inhibit or completely destroy the tumor by light absoption. The integrin is usually ?v?3, ?5?1, ?v?5, ?4?1, or ?2?1. Preferably, the antagonist is an RGD peptide or another antagonist that may be synthetic such as a 4-{2-(3,4,5,6-tetra-hydropyrimidin-2-ylamino)ethyloxy}-benzoyl]amino-2-(S)-amino-ethyl-sulfonylamino group.
Type:
Application
Filed:
September 11, 2008
Publication date:
September 15, 2011
Applicants:
HEALTH RESEARCH, INC., THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
Inventors:
Ravindra K. Pandey, Suresh Pandey, Lalit Goswami, Allan Oseroff, Shipra Dubey, Munawwar Sajjad, Stephanie Pincus