Patents by Inventor Stephen Alister Jones
Stephen Alister Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8252878Abstract: A novel class of polymers obtainable by copolymerising a monomer mixture comprising (i) hydrophilic monomer of general formula (I) Y—B—X; (ii) styrene or a substituted styrene, a monomer or mixture of monomers which when polymerized form a polymer with a Tg lower than the Tg of a homopolymer of monomer (I) and lower than the Tg of a homopolymer of monomer (ii); and a monomer having a crosslinkable group is described. The invention also relates to a method for producing such polymers, implants coated with the polymers and methods for forming the same.Type: GrantFiled: July 16, 2007Date of Patent: August 28, 2012Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Sean Willis, Stephen Alister Jones, Vincent James O'Byrne, David Michael Grey, Michael John Driver, Samantha Ryan, Richard Paul Redman
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Publication number: 20090304770Abstract: A novel class of polymers obtainable by copolymerising a monomer mixture comprising (i) hydrophilic monomer of general formula (I) Y—B—X; (ii) styrene or a substituted styrene, a monomer or mixture of monomers which when polymerised form a polymer with a Tg lower than the Tg of a homopolymer of monomer (I) and lower than the Tg of a homopolymer of monomer (ii); and a monomer having a crosslinkable group is described. The invention also relates to a method for producing such polymers, implants coated with the polymers and methods for forming the same.Type: ApplicationFiled: July 16, 2007Publication date: December 10, 2009Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard Lewis, Sean Willis, Stephen Alister Jones, Vincent James O'Byrne, David Micheal Grey, Michael John Driver, Samantha Ryan, Richard Paul Redman
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Patent number: 7160953Abstract: A biocompatibilizing process in which a substrate having a surface which bears substrate pendant functional groups is biocompatibilized by coating it with a coating composition containing a polymer formed from a radical polymerizable monomers including a radical polymerisable zwitterionic monomer and a radical polymerizable monomer containing a reactive group to form a polymer having zwitterionic groups and pendant reactive groups and the said pendant reactive groups are reacted to form covalent bonds with said substrate pendant functional group and thereby form a stable coating of polymer on the said surface.Type: GrantFiled: March 10, 2004Date of Patent: January 9, 2007Assignee: Biocompatibles UK LimitedInventors: Roderick William Jonathon Bowers, Stephen Alister Jones, Peter William Stratford
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Publication number: 20040176556Abstract: A biocompatibilising process in which a substrate having a surface which bears substrate pendant functional groups is biocompatibilised by coating it with a coating composition containing a polymer formed from a radical polymerisable monomers including a radical polymerisable zwitterionic monomer and a radical polymerisable monomer containing a reactive group to form a polymer having zwitterionic groups and pendant reactive groups and the said pendant reactive groups are reacted to form covalent bonds with said substrate pendant functional group and thereby form a stable coating of polymer on the said surface.Type: ApplicationFiled: March 10, 2004Publication date: September 9, 2004Applicant: BIOCOMPATIBLES LIMITEDInventors: Roderick William Jonathon Bowers, Stephen Alister Jones, Peter William Stratford
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Patent number: 6767979Abstract: A polymer is formed of ethylenically unsaturated monomers including a zwitterionic monomer, an aromatic monomer and a cross-linking monomer. Preferably the crosslinking monomer includes at least one a group containing compound and at least one aliphatic group containing compound. The polymer is water-swellable and a hydrogen has optical and mechanical properties rendering it suitable for use as an intraocular refractive device such as an intraocular lens.Type: GrantFiled: September 20, 2001Date of Patent: July 27, 2004Assignee: Biocompatibles UK LimitedInventors: Andrew Victor Graham Muir, Lee Rowan, Stephen Alister Jones, John Charles Stedman
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Patent number: 6743878Abstract: A biocompatibilising process in which a substrate having a surface which bears substrate pendant functional groups is biocompatibilised by coating it with a coating composition containing a polymer formed from a radical polymerisable monomers including a radical polymerisable zwitterionic monomer and a radical polymerisable monomer containing a reactive group to form a polymer having zwitterionic groups and pendant reactive groups and the said pendant reactive groups are reacted to form covalent bonds with said substrate pendant functional group and thereby form a stable coating of polymer on the said surface.Type: GrantFiled: September 30, 2002Date of Patent: June 1, 2004Assignee: Biocompatibles UK LimitedInventors: Roderick William Jonathon Bowers, Stephen Alister Jones, Peter William Stratford
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Publication number: 20030190405Abstract: A biocompatibilising process in which a substrate having a surface which bears substrate pendant functional groups is biocompatibilised by coating it with a coating composition containing a polymer formed from a radical polymerisable monomers including a radical polymerisable zwitterionic monomer and a radical polymerisable monomer containing a reactive group to form a polymer having zwitterionic groups and pendant reactive groups and the said pendant reactive groups are reacted to form covalent bonds with said substrate pendant functional group and thereby form a stable coating of polymer on the said surface.Type: ApplicationFiled: September 30, 2002Publication date: October 9, 2003Applicant: BIOCOMPATIBLES LIMITEDInventors: Roderick William Jonathon Bowers, Stephen Alister Jones, Peter William Stratford
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Publication number: 20020165324Abstract: Cross-linked copolymers which are obtained by polymerising a neutral diluent monomer or monomers, a monomer or monomers bearing a center of permanent positive charge, and a bifunctional and/or trifunctional cross-linking agent, are suitable for use in contact lenses. Process for producing them by copolymerisation, contact lens material comprising them, contact lenses made of them and processes for producing contact lenses from them.Type: ApplicationFiled: February 28, 2002Publication date: November 7, 2002Applicant: BIOCOMPATIBLES LIMITEDInventors: Roderick William Jonathon Bowers, Peter William Stratford, Stephen Alister Jones
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Patent number: 6423761Abstract: Cross-linked copolymers which are obtainable by polymerising a neutral diluent monomer or monomers, a monomer or monomers bearing a center of permanent positive charge, and a bifunctional and/or trifunctional cross-linking agent, are suitable for use in contact lenses. Process for producing them by copolymerization, contact lens material comprising them, contact lenses made of them and processes for producing contact lenses from them.Type: GrantFiled: June 6, 1995Date of Patent: July 23, 2002Assignee: Biocompatibles LimitedInventors: Roderick William Jonathon Bowers, Peter William Stratford, Stephen Alister Jones
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Patent number: 6420453Abstract: Cross-linked copolymers which are obtainable by polymerizing a neutral diluent monomer or monomers, a monomer or monomers bearing a center of permanent positive charge, and a bifunctional and/or trifunctional cross-linking agent, are suitable for use in contact lenses. Process for producing them by copolymerization, contact lens material comprising them, contact lenses made of them and processes for producing contact lenses from them.Type: GrantFiled: April 28, 1993Date of Patent: July 16, 2002Assignee: Biocompatibles LimitedInventors: Roderick William Jonathon Bowers, Peter William Stratford, Stephen Alister Jones
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Patent number: 6395800Abstract: The biocompatibility of various polymers are improved by blending with them a polymer including a zwitterionic group. The zwitterionic group is usually an ammonium phosphate ester zwitterionic group and the polymer containing it may be produced by the free radical polymerisation of ethylenically unsaturated monomers including a monomer bearing the zwitterionic group. Blending of the two polymers may be achieved by dry blending particulate polymers or by mixing the polymers in liquid dispersion or solution followed by removal of the liquid medium. The fibrinogen absorption and/or platelet activation of polymers may be reduced to a value of less than 80% or even less than 60% of the base polymer by introducing amounts of more than 10% or more than 30% of the zwitterionic group containing polymer. Preferred blends are of copolymers of 2-(methacryloyloxyethyl)-2′-(trimethylammonium)ethyl phosphate inner salt with higher alkyl(meth)acrylate, blended with olefin polymers and/or with rubber latices.Type: GrantFiled: April 14, 2000Date of Patent: May 28, 2002Assignee: Biocompatibles LimitedInventors: Stephen Alister Jones, Peter William Stratford, Steven Rimmer
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Patent number: 6186974Abstract: A glaucoma filtration implant is constituted by a generally tubular body section having an oblong external diameter formed of a continuous convex curve. The device preferably has flow resistance structure provided by a portion of the internal lumen having a reduced diameter. The flow resistance structure may have a length of up to 5000 &mgr;m and a diameter in the range 15 to 50 &mgr;m, the diameter being selected so as to achieve a pressure drop along the flow resistance structure in the range 5 to 15 mm Hg. The internal conduit for liquid flow also may include a removable flow inhibitor, which can be removed after implantation by a laser, such as an ophthalmic YAG laser. The device is made of biocompatible materials.Type: GrantFiled: August 16, 1999Date of Patent: February 13, 2001Assignee: University College London and Moorfields Eye Hospital NHS TrustInventors: Bruce Duncan Samuel Allan, Andrew Victor Graham Muir, Stephen Alister Jones
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Patent number: 6150432Abstract: Disclosed is a polymer blend composition and shaped article, and a process of blending and making shaped articles of polymer blends in which the biocompatibility of various polymers is improved by blending with them a polymer including a zwitterionic group. The zwitterionic group is usually an ammonium phosphate ester, preferably a choline, zwitterionic group and the polymer containing it may be produced by the free radical polymerization of ethylenically unsaturated monomers including a monomer bearing the zwitterionic group. Blending of the two polymers may be achieved by dry blending particulate polymers or by mixing the polymers in liquid dispersion or solution followed by removal of the liquid medium. The fibrinogen absorption and/or platelet activation of polymers may be reduced to a value of less than 80% or even less than 60% of the base polymer by introducing amounts of more than 10% or more than 30% of the zwitterionic group containing polymer.Type: GrantFiled: January 26, 1998Date of Patent: November 21, 2000Assignee: Biocompatibles LimitedInventors: Stephen Alister Jones, Peter William Stratford, Steven Rimmer
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Patent number: 6090901Abstract: A non-crosslinked polymer having pendant zwitterionic groups and pendant functional groups can be coated from a coating composition onto a surface having pendant coreactive functional groups and, after coating, may be cured so that covalent bonds are formed between the coreactive functional groups on the polymer and the surface. Alternatively the polymer can be crosslinked after coating, by formation of covalent intermolecular cross-links between coreactive pendant functional groups on the polymer. The zwitterionic pendant groups preferably have, as the anion, a phosphate ester group, and as the cation, a quaternary ammonium group. The polymer coating is stable and provides improved biocompatibility, especially haemocompatibility.Type: GrantFiled: January 5, 1998Date of Patent: July 18, 2000Assignee: Biocompatibles LimitedInventors: Roderick William Jonathon Bowers, Stephen Alister Jones, Peter William Stratford
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Patent number: 5712326Abstract: The biocompatibility of various polymers is improved by blending with them a polymer including a zwitterionic group. The zwitterionic group is usually an ammonium phosphate ester zwitterionic group and the polymer containing it may be produced by the free radical polymerisation of ethylenically unsaturated monomers including a monomer bearing the zwitterionic group. Blending of the two polymers may be achieved by dry blending particulate polymers or by mixing the polymers in liquid dispersion or solution followed by removal of the liquid medium. The fibrinogen absorption and/or platelet activation of polymers may be reduced to a value of less than 80% or even less than 60% of the base polymer by introducing amounts of more than 10% or mare than 30% of the zwitterionic group containing polymer. Preferred blends are of copolymers of 2-(methacryloyloxyethyl)-2'-(trimethylammonium)ethyl phosphate inner salt with higher alkyl (meth) acrylate, blended with olefin polymers and/or with rubber latices.Type: GrantFiled: December 5, 1994Date of Patent: January 27, 1998Assignee: Biocompatibles LimitedInventors: Stephen Alister Jones, Peter William Stratford, Stephen Rimmer