Patents by Inventor Stephen F. Badylak

Stephen F. Badylak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7795022
    Abstract: A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: September 14, 2010
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak
  • Publication number: 20100222882
    Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
    Type: Application
    Filed: February 26, 2010
    Publication date: September 2, 2010
    Inventors: Stephen F. Badylak, Bryan N. Brown, William L. Chung
  • Patent number: 7776596
    Abstract: A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of urinary bladder submucosa and stomach submucosa, and extracts and hydrolysates thereof, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance initiation of the formation vessel-like structures in the graft construct. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally-derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: August 17, 2010
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak
  • Patent number: 7771717
    Abstract: An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: August 10, 2010
    Assignees: Purdue Research Foundation, Clarian Health Partners, Inc.
    Inventors: Stephen F. Badylak, Khristina Lindberg, George B. Boder, Sherry Voytik-Harbin
  • Publication number: 20100119579
    Abstract: The present invention provides a liver-derived devitalized mammalian parenchymatous tissue composition which includes an interstitial structure of connective tissue which can serve as a scaffold for tissue repair or regeneration. The devitalized mammalian parenchymatous tissue composition can further include the basement membrane of the tissue.
    Type: Application
    Filed: January 14, 2010
    Publication date: May 13, 2010
    Inventor: Stephen F. Badylak
  • Publication number: 20100041135
    Abstract: A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing fastidious organisms is described. Submucosal tissue used in accordance with the present invention supports the proliferation of cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.
    Type: Application
    Filed: July 15, 2009
    Publication date: February 18, 2010
    Inventors: Stephen F. Badylak, George B. Boder, Sherry L. Voytik-Harbin, Matthew S. Waninger, Andrew O. Brightman
  • Publication number: 20090324681
    Abstract: A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired.
    Type: Application
    Filed: September 10, 2009
    Publication date: December 31, 2009
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Stephen F. BADYLAK
  • Patent number: 7608454
    Abstract: A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: October 27, 2009
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak
  • Publication number: 20090123511
    Abstract: A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Application
    Filed: January 6, 2009
    Publication date: May 14, 2009
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Stephen F. Badylak
  • Publication number: 20090118166
    Abstract: The invention provides a composition conditioned for the remodeling, restoration, repair, or replacement of tissue within a host. The composition is conditioned by culturing cells on the matrix and/or by exposing the cultured cells or matrix to one or more stressors.
    Type: Application
    Filed: January 9, 2009
    Publication date: May 7, 2009
    Inventor: Stephen F. Badylak
  • Publication number: 20090074732
    Abstract: The present invention provides a devitalized mammalian parenchymatous tissue composition which includes an interstitial structure which can serve as a scaffold for tissue repair or regeneration. The devitalized mammalian parenchymatous tissue composition can further include the basement membrane of the tissue.
    Type: Application
    Filed: August 14, 2008
    Publication date: March 19, 2009
    Inventor: Stephen F. Badylak
  • Publication number: 20090053279
    Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
    Type: Application
    Filed: March 21, 2008
    Publication date: February 26, 2009
    Inventors: Stephen F. Badylak, Robert S. Tullius, Nathan L. Huber, Kristina Lindberg, Alan R. Spievack
  • Patent number: 7482025
    Abstract: A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: January 27, 2009
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak
  • Publication number: 20080268019
    Abstract: Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
    Type: Application
    Filed: July 6, 2007
    Publication date: October 30, 2008
    Inventors: Stephen F. Badylak, Donald O. Freytes, Thomas W. Gilbert, Jianjun Guan, John Stankus, William R. Wagner
  • Publication number: 20080260831
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Application
    Filed: February 29, 2008
    Publication date: October 23, 2008
    Inventors: Stephen F. Badylak, Donald O. Freytes
  • Patent number: 7175841
    Abstract: An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: February 13, 2007
    Assignee: Purdue Research Foundation
    Inventors: Stephen F Badylak, Christina Lindberg, George B. Boder, Sherry Voytik-Harbin
  • Patent number: 6918396
    Abstract: A method for surgical repair of damaged or diseased head and neck tissues is described. In one aspect of the invention tissue graft constructs comprising vertebrate submucosa or vertebrate basement membrane materials are used to repair and promote growth of endogenous vocal cord tissue.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: July 19, 2005
    Assignees: Purdue Research Foundation, Clarian Health Partners, Inc.
    Inventors: Stephen F. Badylak, Alan R. Spievack
  • Publication number: 20040187877
    Abstract: A method for inducing the repair of damaged or diseased liver tissue in vivo is provided. The method comprises the step of administering to the patient a graft composition comprising basement membrane tissue of a warm-blooded vertebrate in an amount effective to induce the repair of the liver tissue at the site of administration of the graft composition.
    Type: Application
    Filed: December 4, 2003
    Publication date: September 30, 2004
    Inventors: Stephen F. Badylak, Sangeeta N. Bhatia
  • Publication number: 20040191226
    Abstract: A method for inducing the repair of damaged or diseased body wall tissues is provided. In one embodiment, damaged or diseased body wall tissue is replaced with basement membranes of a warm-blooded vertebrate to promote regrowth of body wall tissues to form a multilaminate structure.
    Type: Application
    Filed: December 4, 2003
    Publication date: September 30, 2004
    Inventor: Stephen F. Badylak
  • Patent number: 6793939
    Abstract: A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: September 21, 2004
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak