Abstract: Chimeric antigen receptors having a chlorotoxin domain and an IL-13 are described. These dual targeted chimeric antigen receptors are useful for treating glioblastoma and other cancers of neuroectodermal origin.

Abstract: A system and method for presenting assigned content to a user on a user's device after validating an association of the user with a recognized article based on a valid spatial relationship between the user and the recognized article and also after verifying rights to access the assigned content by the user. The user device equipped with at least one camera used to determine if the article is properly presented. The device captures images and the system has the ability to determine from the images and any additional spatial information the orientation and/or position parameters of the article to confirm whether the valid spatial relationship exists between the recognized article and the user device. The assigned content presented to the user can be contextual and can range from items such as images, music, videos, games, virtual content, augmented content, coupons (virtual or physical), promotions, special offers and the like.

Abstract: A system has a device for capturing biological data from a subject, a machine-readable code associated with the device, an image capturing apparatus with internet connectivity, an image processing unit to interpret the captured biological data, and an internet-connected data repository for storing the interpreted biological data.

Abstract: Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.

Abstract: Immune cells, including T cells, expressing a chimeric antigen receptor targeted to CD45 are described. In some cases, the immune cells lack a functional CD45 gene. In some cases, the immune cells also include a modification (a suicide sequence) that allows the cells to be killed in vivo. The immune cells are useful for treating a variety of cancers.

Abstract: A docking station for removable connection to an enteral feeding pump enables automated flushing of an administration set loaded in the enteral feeding pump. The docking station may have a valve seat configured to receive a switchable flow valve of the administration set, a flush controller, an actuator connected to the flush controller and configured to releasably mate with the switchable flow valve when the switchable flow valve is received by the valve seat, and data communication means by which data signals sent by the enteral feeding pump are inputted to the flush controller of the docking station when the enteral feeding pump is connected to the docking station. In operation, the flush controller may receive a flush command sent by the enteral feeding pump and transmit a control signal to the actuator for switching the switchable flow valve to a flush position in response to the flush command.

Abstract: The present invention relates to the treatment of cancer by irradiation by high energy photons, wherein the cancer has been infused with a heavy metal. The invention further relates to the use of pair-production for increased cancer cell destruction.

Abstract: Systems and methods are provided for partial upgrading of heavy hydrocarbon feeds to meet transport specifications, such as pipeline transport specifications. The systems and methods can allow for one or more types of improvement in heavy hydrocarbon processing prior to transport. In some aspects, the systems and methods can produce a partially upgraded heavy hydrocarbon product that satisfies one or more transport specifications while incorporating an increased amount of vacuum gas oil and a reduced amount of pitch into the partially upgraded heavy hydrocarbon product. In other aspects, the systems and methods can allow for increased incorporation of hydrocarbons into the fraction upgraded for transport, thereby reducing or minimizing the amount of hydrocarbons requiring an alternative method of disposal or transport.

Abstract: An upgraded crude composition is provided, along with systems and methods for making such a composition. The upgraded crude composition can include an unexpectedly high percentage of vacuum gas oil boiling range components while having a reduce or minimized amount of components boiling above 593° C. (1100° F.). In some aspects, based in part on the hydroprocessing used to form the upgraded crude composition, the composition can include unexpectedly high contents of nitrogen. Still other unexpected features of the composition can include, but are not limited to, an unexpectedly high nitrogen content in the naphtha fraction; and an unexpected vacuum gas oil fraction including an unexpectedly high content of polynuclear aromatics, an unexpectedly high content of waxy, paraffinic compounds, and/or an unexpectedly high content of n-pentane asphaltenes.

Abstract: A system has a measuring device adapted to provide a readout indicating a physiological condition of a subject, a machine readable optical code on or closely proximate the measuring device, an imaging apparatus associated with a specific subject, the imaging apparatus having an Internet connection, an image recognition module adapted to process image features to identify the measuring device, and to process the readout portion of the image to determine the physiological condition, and an internet-connected server coupled to a data repository, the Internet-connected server executing coded instructions on a processor. The physiological measuring device is engaged, providing the readout of the physiological condition of the subject, an image of the measuring device including the readout and the machine-readable optical code is captured by the imaging apparatus, and the image is transmitted to the Internet connected server.

Abstract: A method for predicting energy consumption of a vehicle using a statistical model. The method includes (i) predicting a set of future input vectors for the vehicle at defined time intervals corresponding to a plurality of future points in time based on a subset of a plurality of reference input vectors previously generated at the defined time intervals at a plurality of previous points in time, (ii) predicting a change in the energy level of the vehicle using a processor and the statistical model, and (iii) providing results corresponding to the predicted change in the energy level to an output unit of the vehicle. Each reference input vector comprises a vehicle input vector and a database input vector associated with each point in time of the plurality of previous points in time. The database input vector for each defined time interval may be based on at least one of a plurality of environmental data and information about a road condition.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: A ferrule subassembly for a conduit fitting includes first and second ferrules. The first ferrule includes a front body portion defining a forward tapered surface, a rear body portion defining an interior camming surface, and a retaining extension joined with the rear body portion radially outward of the camming surface and extending axially rearward and radially inward from the inner axial portion. The second ferrule includes a front portion having a tapered forward contact surface adjacent the first ferrule camming surface, an outer radial portion extending axially rearward of the forward contact surface, and a recessed portion axially rearward of the outer radial portion. An end portion of the retaining extension is received in the recessed portion of the second ferrule to retain the second ferrule with the first ferrule as a discontinuous subassembly.

Abstract: A system and method for identifying whether an article is properly presented and duly owned by or licensed to a user and releasing assigned content to the user upon confirmation of such verifiably owned or licensed article. A manipulated user device equipped with at least one camera is deployed to determine if the article is properly presented. The device captures images and the system has the ability to determine from the images and any additional spatial information the orientation and/or position parameters of the article to confirm whether a valid spatial relationship exists between the article and the user device. Due ownership or license is verified by relying on tokens (e.g., Non-Fungible Tokens) and blockchain transaction records. The assigned content released to the user can be contextual and can range from items such as images, music, videos, games, virtual content, augmented content, coupons (virtual or physical), promotions, special offers and the like.

Abstract: A system for monitoring injuries comprising a plurality of wearable user input devices and a wireless transceiver. Each of the plurality of wearable user input devices may be configured to detect motion patterns of a user. Each of the plurality of wearable user input devices may be configured as performance equipment. The wireless transceiver may be configured to communicate the motion patterns to a user device. The user device may be configured to (i) develop and store reference patterns related to impacts, (ii) compare the detected motion patterns with the reference patterns, (iii) estimate a location and direction of an impact based on the comparison, (iv) accumulate data from the estimated impact with previously suffered impact data, (v) aggregate results based on the accumulated impact data and context information and (vi) generate feedback for the user based on the aggregated results.

Abstract: A power management system includes a sensor interface that receives sensor data samples during operation of a vehicle. A storage device stores the sensor data samples for multiple points in time along a route segment traveled by the vehicle. One or more processors analyze the sensor data samples to detect a historical pattern of the vehicle. The one or more processors determine time efficient operational parameters for the vehicle in response to a destination and an estimated travel time to the destination. The estimated travel time may be based on predicted conditions of the vehicle indicated by the historical pattern. The time efficient operational parameters may be selected to decrease the estimated travel time. At least one of the sensor data samples may include telemetry data.

Abstract: A system has a measuring device adapted to provide a readout indicating a physiological condition of a subject, a machine readable optical code on or closely proximate the measuring device, an imaging apparatus associated with a specific subject, the imaging apparatus having an Internet connection, an image recognition module adapted to process image features to identify the measuring device, and to process the readout portion of the image to determine the physiological condition, and an internet-connected server coupled to a data repository, the Internet-connected server executing coded instructions on a processor. The physiological measuring device is engaged, providing the readout of the physiological condition of the subject, an image of the measuring device including the readout and the machine-readable optical code is captured by the imaging apparatus, and the image is transmitted to the Internet connected server.

Abstract: An apparatus comprising a power source, one or more sensors, a transceiver, and a memory. The power source may be configured to store energy to power the apparatus. The one or more sensors may be configured to receive captured data from one of a plurality of sources. The transceiver may be configured to send and receive data to and from a wireless network. The processor may be configured to execute computer readable instructions. The memory may be configured to store a set of instructions executable by the processor. The instructions may be configured to (A) evaluate an expected power usage budget calculated using a predictive model of future energy consumption and (B) (i) store the captured data in the memory in a first mode and (ii) transmit the captured data to a remote storage device in a second mode. The first mode or the second mode is selected based on characteristics of the captured data received from the sensors.

Abstract: A docking station for removable connection to an enteral feeding pump enables automated flushing of an administration set loaded in the enteral feeding pump. The docking station may have a valve seat configured to receive a switchable flow valve of the administration set, a flush controller, an actuator connected to the flush controller and configured to releasably mate with the switchable flow valve when the switchable flow valve is received by the valve seat, and data communication means by which data signals sent by the enteral feeding pump are inputted to the flush controller of the docking station when the enteral feeding pump is connected to the docking station. In operation, the flush controller may receive a flush command sent by the enteral feeding pump and transmit a control signal to the actuator for switching the switchable flow valve to a flush position in response to the flush command.

Abstract: A system has a measuring device providing a readout of a physiological condition, an imaging apparatus with an Internet connection, an image recognition module executing on the imaging apparatus, the image recognition module adapted to compare images to a library of options, and to process the readout by optical character recognition (OCR), and an internet-connected server coupled to a data repository, the Internet-connected server executing coded instructions on a processor.