Patents by Inventor Stephen J. Chudzik
Stephen J. Chudzik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6924370Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.Type: GrantFiled: June 20, 2002Date of Patent: August 2, 2005Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, David L. Clapper
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Patent number: 6890583Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: November 21, 2001Date of Patent: May 10, 2005Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke
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Publication number: 20040202774Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.Type: ApplicationFiled: April 10, 2003Publication date: October 14, 2004Applicant: SurModics, Inc.Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
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Publication number: 20040203075Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic &bgr; cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.Type: ApplicationFiled: April 10, 2003Publication date: October 14, 2004Applicant: SurModics, Inc.Inventors: Stephen J. Chudzik, Dale G. Swan
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Publication number: 20040137164Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.Type: ApplicationFiled: December 23, 2003Publication date: July 15, 2004Applicant: SURMODICS, INC.Inventors: Dale G. Swan, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Ralph A. Chappa, Sean M. Stucke, Peter H. Duquette
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Patent number: 6669994Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.Type: GrantFiled: April 23, 2001Date of Patent: December 30, 2003Assignee: SurModics, Inc.Inventors: Dale G. Swan, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Ralph A. Chappa, Sean M. Stucke, Peter H. Duquette
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Publication number: 20030165613Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.Type: ApplicationFiled: December 21, 2001Publication date: September 4, 2003Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Dale G. Swan, Peter H. Duquette
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Publication number: 20030031697Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.Type: ApplicationFiled: June 20, 2002Publication date: February 13, 2003Inventors: Stephen J. Chudzik, David L. Clapper
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Publication number: 20030031780Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: October 10, 2002Publication date: February 13, 2003Inventors: Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke
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Publication number: 20020188037Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: June 18, 2002Publication date: December 12, 2002Inventors: Stephen J. Chudzik, Timothy M. Kloke, Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran
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Patent number: 6410044Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.Type: GrantFiled: May 16, 2000Date of Patent: June 25, 2002Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, David L. Clapper
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Publication number: 20020041899Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.Type: ApplicationFiled: July 9, 2001Publication date: April 11, 2002Inventors: Stephen J. Chudzik, Terrence P. Everson, Richard A. Amos
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Publication number: 20020032434Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: November 21, 2001Publication date: March 14, 2002Inventors: Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke
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Patent number: 6344035Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: October 20, 2000Date of Patent: February 5, 2002Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke
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Publication number: 20020004140Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.Type: ApplicationFiled: April 23, 2001Publication date: January 10, 2002Inventors: Dale G. Swan, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Palph A. Chappa, Sean M. Stucke, Peter H. Duquette
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Patent number: 6214901Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: April 15, 1999Date of Patent: April 10, 2001Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke
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Patent number: 6156345Abstract: A crosslinkable macromer system that includes two or more polymer-pendent polymerizable groups and one or more polymer-pendent initiator groups. The polymerizable groups and the initiator group(s) can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility.Type: GrantFiled: December 21, 1999Date of Patent: December 5, 2000Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, Aron B. Anderson
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Patent number: 6007833Abstract: A crosslinkable macromer system that includes two or more polymer-pendent polymerizable groups and one or more polymer-pendent initiator groups. The polymerizable groups and the initiator group(s) can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility.Type: GrantFiled: July 23, 1998Date of Patent: December 28, 1999Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, Aron B. Anderson
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Patent number: 5981298Abstract: A device and related method for performing one or more immunoassays to detect the presence of respective analytes in a sample. The device involves the use of a unitary bibulous material providing one or more flow paths having a common origin site and a plurality of respective reagent zones providing the reagents necessary for performing a visual readout, competitive immunoassay for the presence of the respective analyte.Type: GrantFiled: September 30, 1997Date of Patent: November 9, 1999Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, Martha J. Hamilton
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Patent number: 5707818Abstract: A device and related method for simultaneously performing a plurality of immunoassays to detect the presence of respective analytes in a sample. The device involves the use of a unitary bibulous material providing one or more flow paths having a common origin site and a plurality of respective reagent zones providing the reagents necessary for performing a visual read-out, competitive immunoassay for the presence of the respective analyte.Type: GrantFiled: December 13, 1994Date of Patent: January 13, 1998Assignee: BSI CorporationInventors: Stephen J. Chudzik, Martha J. Hamilton